Study finds link between depression, brain inflammation
Source: CTV
Canadian scientists say theyve made a big breakthrough in depression research with a new study that found inflammation deep in the brains of patients suffering from the illness.
While the research is still in its early stages, it provides scientists with a possible alternative cause for the disease, and an explanation for why between 30 and 50 per cent of patients with depression dont respond to medication.
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They found that those with depression had an average 30 per cent more inflammation in their brains.
And the greater the inflammation, the more severe the patients symptoms.
The researchers say their findings are significant, and raise the question of whether getting rid of the inflammation would eliminate depression altogether.
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Read more: http://www.ctvnews.ca/health/study-finds-link-between-depression-brain-inflammation-1.2210121
truthisfreedom
(23,146 posts)Like Aspirin.
bananas
(27,509 posts)Study: Inflammation Causes Depression in Many Cases
By Douglas Main 1/28/15 at 3:42 PM
Depression is one of the most common mental health problems, affecting about one in 10 Americans every year. And it remains difficult to treat; As many as 50 percent of people dont respond to typical medications.
It used to be widely thought that depression was caused by a chemical imbalance, and antidepressant drugs still primarily target the neurotransmitter serotonin, seeking to increase its activity in the brain. But new research in the past two decades has uncovered more and more information linking the illness with inflammation, the process the body goes through to fight infection or heal trauma. But inflammation may be present in excessive or harmful levels in depressed people, perhaps triggered by an illness, stress or for some other unknown biochemical reason.
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But these studies have mostly looked for signs of inflammation in the blood, and not necessarily at the time of a depressive episode. A new study, published Wednesday in the journal JAMA Psychiatry, found significant increases of inflammation within the brains of people who were depressed at the time.
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What to do now? Meyers previous work suggests that between 30 and 40 percent of people with depression have increased levels of inflammation, and that these people are unlikely to directly benefit from typical antidepressants, such as selective serotonin reuptake inhibitors like Prozac, that dont have anti-inflammatory properties, he says. So they may benefit from something that directly treats inflammation.
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jwirr
(39,215 posts)dixiegrrrrl
(60,010 posts)If inflammation is linked to depression, what is linked to mania ( assuming no uppers are being used).
And do anti-inflammation drugs such as aspirin, etc normally used for joint inflammation, impact the brain?
It was not that long ago that studies showed anti-biotics worked for ulcers.
jwirr
(39,215 posts)of bi-polar.
magical thyme
(14,881 posts)that is why antibiotics are effective in ulcers. For a long time, medical researchers didn't believe that bacteria could survive the acid environment of the stomach. An Australian researcher proposed that h. pylori could survive; in order to prove it he swallowed a batch and nearly killed himself in the process.
What anti-inflammatories might work in the brain will depend in at least in part on whether they can pass through the blood-brain barrier.
upaloopa
(11,417 posts)So what about the rest of us? Shoud we give up our meds because of the 30%?
BlancheSplanchnik
(20,219 posts)And sudden reduction in inflammation ?
Hmmmm......maybe not..I'm not bi-polar, but I assume thassume the mania lasts longer than inflammation reduction alone would explain.
jwirr
(39,215 posts)definitely depressed much more than manic.
BlancheSplanchnik
(20,219 posts)Which makes sense. It doesn't feel like something other than an understandable "pendulum swing" to me.
But, I've also got long term Complex-PTSD, so again, it makes sense that when I'm doing well, it feels a little giddy cuz of the relief.
I don't have any personal experience of bi-polar, so I can't speculate.
jwirr
(39,215 posts)to the swings are different for everyone. And it would be hard to tell if it was from bi-polar or just the giddy reaction of relief that you mention. These are all questions that this new study raises.
BlancheSplanchnik
(20,219 posts)Yeah, depression goes with PTSD, C and non-C.....
In my experience, the depression actually "helps" the anxiety...tamps down the extreme discomfort. But, then of course, is a problem itself,,and the whole thing can feed into itself.
jwirr
(39,215 posts)world of hurt out there. So many unanswered problems.
bananas
(27,509 posts)From the same NewsWeek article:
It isnt currently known for sure what existing drugs may treat this type of neurological inflammation, Meyer says, though many groups are looking into it. He and his collaborators plan to test the effects of minocycline, an antibiotic that has the secondary effect of reducing glial inflammation, at least in rodents. And other researchers are looking at other anti-inflammatory agents, such as a chemical called celecoxib.
Those embedded links go to these articles:
Novel therapeutic targets in depression: Minocycline as a candidate treatment
The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine
Duval
(4,280 posts)our Dermatologist for skin breakouts. His is due to the cold and dry air, and mine is due to inflammation from within the body. We take Curcumin and also Botsweilla, which are supposed to fight inflammation. Apparently these aren't helping me much!
I was wondering if some antidepressants increase inflammation, so I googled Remeron. I was not surprised to find tons of side effects, one being skin breakouts but they don't come out and say "inflammation". Thank you for the post, bananas.
that we have a lot of different tissues, and a drug that causes inflammation in one kind of tissue won't necessarily create inflammation in other tissues.
magical thyme
(14,881 posts)On the other hand, aspirin takes care of sinus inflammation. Less effective for gut...
Dont call me Shirley
(10,998 posts)dixiegrrrrl
(60,010 posts)The exact months he had to start wearing warm clothes.
He did go to a skin doc who prescribed Prozac, and I do notice he seems in a lighter mood on it.
But, we have now seen, after 18 months, the pattern of outbreak come and go depending on lightly he has to dress.
Spring ( 70 degree temps) thru fall, no outbreak.
One of the joys of aging is that you get to experience brand new body issues!
bananas
(27,509 posts)Eh, you probably already do that.
Never mind.
I'll throw it out there for other people.
dixiegrrrrl
(60,010 posts)Since he can wear the summer shirts that have been washed in detergent, with no problem, etc.
Not too sure how the Prozac is doing re: the rash....
but it IS helpful for S.A.D., at least for him, so there is that.
tridim
(45,358 posts)And people tend to eat lots of junk carbs (as recommended by the FDA) to help them forget about the pain that is caused by those same carbs.
Following the horrible advice here...
...will cause inflammation all over your body.
shawn703
(2,702 posts)there is inflammation caused by vaccines. It's how they work.
Peace
Nitram
(22,794 posts)No, vaccines primarily work by stimulating the body's immune system to recognize the agent as foreign, destroy it, and keep a record of it, so that the immune system can more easily recognize and destroy any of these microorganisms that it later encounters. The immune system response to a vaccine is due to the detection of an antigen, not inflamation.
Hekate
(90,657 posts)stage left
(2,962 posts)Interesting. My daughter has Bipolar that is mainly depressive. Bookmarking to read later.
Blue_Tires
(55,445 posts)my brain has definitely been on fire as of late
Utopian Leftist
(534 posts)Marijuana has well-documented anti-inflammatory affects.
tridim
(45,358 posts)if the patient didn't have to constantly worry about getting arrested and jailed for using a natural medicine.
snooper2
(30,151 posts)I literally had a state trooper pass me on the highway this past weeked while I was puffing away!
Hey, don't look at me dude just smoking a cig
Liberalynn
(7,549 posts)I was diagnosed years ago. Talk therapy and medication have helped some but it has never truly lifted all the way plus I often have issues with severe anxiety. I would love it if they 've found a cure.
Bearware
(151 posts)In may CNS neurological diseases there is a low level of inflammation in the brain. This can result in an increase of insulin resistance by brain cells. When this occurs, those brain cells may end up running lean - not getting the glucose they need for normal function. In this situation coconut oil can help. Compared to most other fats, coconut oil is relatively quickly absorbed. When it leaves the stomach it is quickly absorbed by the intestines and sent up the portal vein to the liver rather than later coming back through the lymph system. In the liver it is (again) relatively quickly converted into ketone bodies which can cross the blood brain barrier. Neurons that are running lean (can't get enough glucose) can use those ketones (fats) to make up the energy deficit and will thus function better.
I don't know if this would affect the inflammation but it will definitely make up the energy deficit if insulin resistance is present in the neurons. It's not magic so it doesn't cure the underlying cause(s) but in quite a few cases it can have a substantial positive effect. There are videos on it's effect for Alzheimer's disease. I have personal experience with it working like gangbusters for people with brain fog and memory loss from type 2 diabetes and other diseases such as MS. Again it is not magic and does not work for everyone/everything.
If you have depression, it is very cheap to buy coconut oil and substantial numbers of people with other CNS neurological disease have an easy to recognize improvement by the afternoon if they take up to 1-2 tbsp in the morning. It doesn't work for everybody, it is a good ideal to take it with food or you can get an upset stomach and you can use either organic, extra virgin coconut oil or you can spend more and use MCT oil (which is distilled from coconut oil). I use soya lecithin to emulsify it in body temperature (coconut oil is solid below 73 F)water or juice so I can drink it directly without that oily taste.
If anyone here with depression tries coconut oil I would be interested in what happened. Some people may need to start with a lower amount and slowly increase it. I recommend it in the morning or at lunch as it may keep you awake at night if you take it with dinner. I you think some coconut oil good (1-2 tbsp) then a lot more is better, you are likely to get stomach cramps all night and who knows what will come out your end.
libdem4life
(13,877 posts)malfunctions...including autism. This site ... http://www.ncbi.nlm.nih.gov/pubmed/ ... is what doctors use for reference and I sure found out a lot that can help my son. Now I know where to go for other people or information as well.