Welcome to DU! The truly grassroots left-of-center political community where regular people, not algorithms, drive the discussions and set the standards. Join the community: Create a free account Support DU (and get rid of ads!): Become a Star Member Latest Breaking News General Discussion The DU Lounge All Forums Issue Forums Culture Forums Alliance Forums Region Forums Support Forums Help & Search

bananas

(27,509 posts)
Thu Jan 29, 2015, 09:39 AM Jan 2015

Study finds link between depression, brain inflammation

Source: CTV

Canadian scientists say they’ve made a big breakthrough in depression research with a new study that found inflammation deep in the brains of patients suffering from the illness.

While the research is still in its early stages, it provides scientists with a possible alternative cause for the disease, and an explanation for why between 30 and 50 per cent of patients with depression don’t respond to medication.

<snip>

They found that those with depression had an average 30 per cent more inflammation in their brains.

And the greater the inflammation, the more severe the patient’s symptoms.

The researchers say their findings are significant, and raise the question of whether getting rid of the inflammation would eliminate depression altogether.

<snip>

Read more: http://www.ctvnews.ca/health/study-finds-link-between-depression-brain-inflammation-1.2210121

34 replies = new reply since forum marked as read
Highlight: NoneDon't highlight anything 5 newestHighlight 5 most recent replies
Study finds link between depression, brain inflammation (Original Post) bananas Jan 2015 OP
Which is why ibuprofen is an interesting antidepressant. truthisfreedom Jan 2015 #1
Study: Inflammation Causes Depression in Many Cases bananas Jan 2015 #2
Stupid question: Does this apply to bi-polar as well? jwirr Jan 2015 #3
An excellent question, actually. dixiegrrrrl Jan 2015 #5
I hope they add this to the study if they are not looking at that. Depression is definitely a part jwirr Jan 2015 #6
a large percentage of ulcers are caused by helicobacter pylori magical thyme Jan 2015 #16
It said 30% of depression upaloopa Jan 2015 #26
I wonder if there's a link between the manic phase BlancheSplanchnik Jan 2015 #8
The mania and depressive cycle in persons with bi-polar is different for everyone. My brother is jwirr Jan 2015 #9
I get kind of giddy when my depression lifts BlancheSplanchnik Jan 2015 #10
I don't know a lot about PTSD but doesn't that have an element of depression to it also? And as jwirr Jan 2015 #11
wish we could be in the question-asking room with them. BlancheSplanchnik Jan 2015 #18
Yes, it seems that balancing the anxiety and the depression would be the goal. We really have a jwirr Jan 2015 #19
A little more, on some drugs they're looking into (antibiotics and anti-inflammants) bananas Jan 2015 #29
My husband and I just returned from Duval Jan 2015 #4
Keep in mind jeff47 Jan 2015 #7
I find curcurmin works very well for gut inflammation; doesn't touch my sinuses magical thyme Jan 2015 #17
Ashwaganda works well. Dont call me Shirley Jan 2015 #21
As of last year, Mr. Dixie had skin rashes, which started in Oct. and left in April. dixiegrrrrl Jan 2015 #24
Maybe it's the detergent, try using a hypo-allergenic one free of perfumes and dyes. bananas Jan 2015 #31
Yeah, we did that. dixiegrrrrl Jan 2015 #34
Yep, inflammation is a huge problem all over the body. tridim Jan 2015 #12
And the anti-vaxxers will claim this is caused by vaccines in 3...2...1... Nt shawn703 Jan 2015 #13
well, yes lebkr Jan 2015 #20
"It's how they work?" Not. Nitram Jan 2015 #23
Bookmarking to share link later. This looks promising. nt Hekate Jan 2015 #14
k&R stage left Jan 2015 #15
kick Blue_Tires Jan 2015 #22
Not so surprising then that cannabis works so well for depression . . . Utopian Leftist Jan 2015 #25
And imagine how well it would work for anxiety and depression... tridim Jan 2015 #27
That is why they make dugouts with pipes that look like cigs snooper2 Jan 2015 #28
It will be interesting to see how it all plays out. Liberalynn Jan 2015 #30
Inflammation may increase insulin resistance in the brain , if this is the case coconut oil may help Bearware Jan 2015 #32
Also gut inflammation and lots of new work on gluten sensitivity and all manner of brain libdem4life Jan 2015 #33

bananas

(27,509 posts)
2. Study: Inflammation Causes Depression in Many Cases
Thu Jan 29, 2015, 09:48 AM
Jan 2015
http://www.newsweek.com/inflammation-causes-depression-many-cases-study-says-302799?piano_t=1

Study: Inflammation Causes Depression in Many Cases
By Douglas Main 1/28/15 at 3:42 PM

Depression is one of the most common mental health problems, affecting about one in 10 Americans every year. And it remains difficult to treat; As many as 50 percent of people don’t respond to typical medications.

It used to be widely thought that depression was caused by a “chemical imbalance,” and antidepressant drugs still primarily target the neurotransmitter serotonin, seeking to increase its activity in the brain. But new research in the past two decades has uncovered more and more information linking the illness with inflammation, the process the body goes through to fight infection or heal trauma. But inflammation may be present in excessive or harmful levels in depressed people, perhaps triggered by an illness, stress or for some other unknown biochemical reason.

<snip>

But these studies have mostly looked for signs of inflammation in the blood, and not necessarily at the time of a depressive episode. A new study, published Wednesday in the journal JAMA Psychiatry, found significant increases of inflammation within the brains of people who were depressed at the time.

<snip>

What to do now? Meyer’s previous work suggests that between 30 and 40 percent of people with depression have increased levels of inflammation, and that these people are unlikely to directly benefit from typical antidepressants, such as selective serotonin reuptake inhibitors like Prozac, that don’t have anti-inflammatory properties, he says. So they may benefit from something that directly treats inflammation.

<snip>

dixiegrrrrl

(60,010 posts)
5. An excellent question, actually.
Thu Jan 29, 2015, 11:21 AM
Jan 2015

If inflammation is linked to depression, what is linked to mania ( assuming no uppers are being used).

And do anti-inflammation drugs such as aspirin, etc normally used for joint inflammation, impact the brain?

It was not that long ago that studies showed anti-biotics worked for ulcers.

jwirr

(39,215 posts)
6. I hope they add this to the study if they are not looking at that. Depression is definitely a part
Thu Jan 29, 2015, 11:24 AM
Jan 2015

of bi-polar.

 

magical thyme

(14,881 posts)
16. a large percentage of ulcers are caused by helicobacter pylori
Thu Jan 29, 2015, 12:28 PM
Jan 2015

that is why antibiotics are effective in ulcers. For a long time, medical researchers didn't believe that bacteria could survive the acid environment of the stomach. An Australian researcher proposed that h. pylori could survive; in order to prove it he swallowed a batch and nearly killed himself in the process.

What anti-inflammatories might work in the brain will depend in at least in part on whether they can pass through the blood-brain barrier.

upaloopa

(11,417 posts)
26. It said 30% of depression
Thu Jan 29, 2015, 05:18 PM
Jan 2015

So what about the rest of us? Shoud we give up our meds because of the 30%?

BlancheSplanchnik

(20,219 posts)
8. I wonder if there's a link between the manic phase
Thu Jan 29, 2015, 11:32 AM
Jan 2015

And sudden reduction in inflammation ?

Hmmmm......maybe not..I'm not bi-polar, but I assume thassume the mania lasts longer than inflammation reduction alone would explain.

jwirr

(39,215 posts)
9. The mania and depressive cycle in persons with bi-polar is different for everyone. My brother is
Thu Jan 29, 2015, 11:34 AM
Jan 2015

definitely depressed much more than manic.

BlancheSplanchnik

(20,219 posts)
10. I get kind of giddy when my depression lifts
Thu Jan 29, 2015, 11:40 AM
Jan 2015

Which makes sense. It doesn't feel like something other than an understandable "pendulum swing" to me.

But, I've also got long term Complex-PTSD, so again, it makes sense that when I'm doing well, it feels a little giddy cuz of the relief.

I don't have any personal experience of bi-polar, so I can't speculate.

jwirr

(39,215 posts)
11. I don't know a lot about PTSD but doesn't that have an element of depression to it also? And as
Thu Jan 29, 2015, 11:46 AM
Jan 2015

to the swings are different for everyone. And it would be hard to tell if it was from bi-polar or just the giddy reaction of relief that you mention. These are all questions that this new study raises.

BlancheSplanchnik

(20,219 posts)
18. wish we could be in the question-asking room with them.
Thu Jan 29, 2015, 12:48 PM
Jan 2015

Yeah, depression goes with PTSD, C and non-C.....
In my experience, the depression actually "helps" the anxiety...tamps down the extreme discomfort. But, then of course, is a problem itself,,and the whole thing can feed into itself.

jwirr

(39,215 posts)
19. Yes, it seems that balancing the anxiety and the depression would be the goal. We really have a
Thu Jan 29, 2015, 12:55 PM
Jan 2015

world of hurt out there. So many unanswered problems.

bananas

(27,509 posts)
29. A little more, on some drugs they're looking into (antibiotics and anti-inflammants)
Thu Jan 29, 2015, 05:38 PM
Jan 2015

From the same NewsWeek article:

http://www.newsweek.com/inflammation-causes-depression-many-cases-study-says-302799?piano_t=1

It isn’t currently known for sure what existing drugs may treat this type of neurological inflammation, Meyer says, though many groups are looking into it. He and his collaborators plan to test the effects of minocycline, an antibiotic that has the secondary effect of reducing glial inflammation, at least in rodents. And other researchers are looking at other anti-inflammatory agents, such as a chemical called celecoxib.


Those embedded links go to these articles:

http://www.sciencedirect.com/science/article/pii/S0166432812004822

Novel therapeutic targets in depression: Minocycline as a candidate treatment


http://www.nature.com/mp/journal/v11/n7/full/4001805a.html

The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine


 

Duval

(4,280 posts)
4. My husband and I just returned from
Thu Jan 29, 2015, 10:56 AM
Jan 2015

our Dermatologist for skin breakouts. His is due to the cold and dry air, and mine is due to inflammation from within the body. We take Curcumin and also Botsweilla, which are supposed to fight inflammation. Apparently these aren't helping me much!

I was wondering if some antidepressants increase inflammation, so I googled Remeron. I was not surprised to find tons of side effects, one being skin breakouts but they don't come out and say "inflammation". Thank you for the post, bananas.



jeff47

(26,549 posts)
7. Keep in mind
Thu Jan 29, 2015, 11:26 AM
Jan 2015

that we have a lot of different tissues, and a drug that causes inflammation in one kind of tissue won't necessarily create inflammation in other tissues.

 

magical thyme

(14,881 posts)
17. I find curcurmin works very well for gut inflammation; doesn't touch my sinuses
Thu Jan 29, 2015, 12:32 PM
Jan 2015

On the other hand, aspirin takes care of sinus inflammation. Less effective for gut...

dixiegrrrrl

(60,010 posts)
24. As of last year, Mr. Dixie had skin rashes, which started in Oct. and left in April.
Thu Jan 29, 2015, 03:50 PM
Jan 2015

The exact months he had to start wearing warm clothes.
He did go to a skin doc who prescribed Prozac, and I do notice he seems in a lighter mood on it.
But, we have now seen, after 18 months, the pattern of outbreak come and go depending on lightly he has to dress.
Spring ( 70 degree temps) thru fall, no outbreak.

One of the joys of aging is that you get to experience brand new body issues!

bananas

(27,509 posts)
31. Maybe it's the detergent, try using a hypo-allergenic one free of perfumes and dyes.
Thu Jan 29, 2015, 09:57 PM
Jan 2015

Eh, you probably already do that.
Never mind.
I'll throw it out there for other people.

dixiegrrrrl

(60,010 posts)
34. Yeah, we did that.
Fri Jan 30, 2015, 12:21 AM
Jan 2015

Since he can wear the summer shirts that have been washed in detergent, with no problem, etc.

Not too sure how the Prozac is doing re: the rash....
but it IS helpful for S.A.D., at least for him, so there is that.

tridim

(45,358 posts)
12. Yep, inflammation is a huge problem all over the body.
Thu Jan 29, 2015, 12:03 PM
Jan 2015

And people tend to eat lots of junk carbs (as recommended by the FDA) to help them forget about the pain that is caused by those same carbs.

Following the horrible advice here...



...will cause inflammation all over your body.

Nitram

(22,794 posts)
23. "It's how they work?" Not.
Thu Jan 29, 2015, 03:29 PM
Jan 2015

No, vaccines primarily work by stimulating the body's immune system to recognize the agent as foreign, destroy it, and keep a record of it, so that the immune system can more easily recognize and destroy any of these microorganisms that it later encounters. The immune system response to a vaccine is due to the detection of an antigen, not inflamation.

Utopian Leftist

(534 posts)
25. Not so surprising then that cannabis works so well for depression . . .
Thu Jan 29, 2015, 05:15 PM
Jan 2015

Marijuana has well-documented anti-inflammatory affects.

tridim

(45,358 posts)
27. And imagine how well it would work for anxiety and depression...
Thu Jan 29, 2015, 05:19 PM
Jan 2015

if the patient didn't have to constantly worry about getting arrested and jailed for using a natural medicine.

 

snooper2

(30,151 posts)
28. That is why they make dugouts with pipes that look like cigs
Thu Jan 29, 2015, 05:35 PM
Jan 2015

I literally had a state trooper pass me on the highway this past weeked while I was puffing away!

Hey, don't look at me dude just smoking a cig

 

Liberalynn

(7,549 posts)
30. It will be interesting to see how it all plays out.
Thu Jan 29, 2015, 08:35 PM
Jan 2015

I was diagnosed years ago. Talk therapy and medication have helped some but it has never truly lifted all the way plus I often have issues with severe anxiety. I would love it if they 've found a cure.

Bearware

(151 posts)
32. Inflammation may increase insulin resistance in the brain , if this is the case coconut oil may help
Thu Jan 29, 2015, 10:03 PM
Jan 2015

In may CNS neurological diseases there is a low level of inflammation in the brain. This can result in an increase of insulin resistance by brain cells. When this occurs, those brain cells may end up running lean - not getting the glucose they need for normal function. In this situation coconut oil can help. Compared to most other fats, coconut oil is relatively quickly absorbed. When it leaves the stomach it is quickly absorbed by the intestines and sent up the portal vein to the liver rather than later coming back through the lymph system. In the liver it is (again) relatively quickly converted into ketone bodies which can cross the blood brain barrier. Neurons that are running lean (can't get enough glucose) can use those ketones (fats) to make up the energy deficit and will thus function better.

I don't know if this would affect the inflammation but it will definitely make up the energy deficit if insulin resistance is present in the neurons. It's not magic so it doesn't cure the underlying cause(s) but in quite a few cases it can have a substantial positive effect. There are videos on it's effect for Alzheimer's disease. I have personal experience with it working like gangbusters for people with brain fog and memory loss from type 2 diabetes and other diseases such as MS. Again it is not magic and does not work for everyone/everything.


If you have depression, it is very cheap to buy coconut oil and substantial numbers of people with other CNS neurological disease have an easy to recognize improvement by the afternoon if they take up to 1-2 tbsp in the morning. It doesn't work for everybody, it is a good ideal to take it with food or you can get an upset stomach and you can use either organic, extra virgin coconut oil or you can spend more and use MCT oil (which is distilled from coconut oil). I use soya lecithin to emulsify it in body temperature (coconut oil is solid below 73 F)water or juice so I can drink it directly without that oily taste.


If anyone here with depression tries coconut oil I would be interested in what happened. Some people may need to start with a lower amount and slowly increase it. I recommend it in the morning or at lunch as it may keep you awake at night if you take it with dinner. I you think some coconut oil good (1-2 tbsp) then a lot more is better, you are likely to get stomach cramps all night and who knows what will come out your end.

 

libdem4life

(13,877 posts)
33. Also gut inflammation and lots of new work on gluten sensitivity and all manner of brain
Thu Jan 29, 2015, 11:23 PM
Jan 2015

malfunctions...including autism. This site ... http://www.ncbi.nlm.nih.gov/pubmed/ ... is what doctors use for reference and I sure found out a lot that can help my son. Now I know where to go for other people or information as well.

Latest Discussions»Latest Breaking News»Study finds link between ...