Drug shown to prevent and treat diabetes in mice

[tomm2thumbs]

Source: Gizmag

Research carried out at the University of California (UC), Davis and the University of Barcelona has uncovered an enzyme inhibitor found to prevent and reverse the effects of diabetes in obese mice. (snip)

Previously observed in the lab at UC Davis, the researchers say that the drug they are working on has either reduced or reversed diabetes-related ailments such as renal failure, hypertension, diabetic pain, hardening of the arteries and heart failure.

Now research conducted by Joan Clària, an associate professor at the Barcelona School of Medicine, takes things a little further. She reported the discovery that for mice that happen to have higher levels of certain fatty acids, the drug actually provided a cure for the disease.

Read more: http://www.gizmag.com/uc-medication-diabetes-mice/35556/

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A potent enzyme inhibitor, discovered earlier by Bruce Hammock and colleagues at UC Davis, is now shown to reverse diabetes symptoms in obese mice. Hammock's start-up is putting the new compounds into clinical trials for companion animals and the Pre-Investigational New Drug Application, or Pre-IND, Consultation Program for neuropathic pain in human diabetics.

The study was funded by Clària’s Spanish-initiated grants and by Hammock’s Research Project Grant (R01) and Superfund grants from the National Institutes of Health.


Link to UC Davis article
http://news.ucdavis.edu/search/news_detail.lasso?id=11134

Link to the study
http://www.pnas.org/content/early/2014/12/30/1422590112.abstract

[ND-Dem]

1. I'm skeptical. DM2 is typically associated with obesity. Can one drug reverse all the

associated ills? Seems unlikely to me.

[Chemisse]

2. I believe that something simple could stop diabetes 2,

Since certain types of stomach surgery have had that exact effect.

However, I can't believe that the damage already done would be reversed.

[FarPoint]

4. Obesity is only a fraction of DM2.

Weight loss is an effective intervention for obesity enduced DM2...Many thin and/ aging individuals have DM2.

[ND-Dem]

7. ...

Carrying excess weight is clearly linked to Type 2 diabetes. Nationwide, more than half of adults with the disease are obese, and 30 percent or more are overweight. Being obese not only makes the disease more likely, but is also associated with worse control of blood sugar levels, blood pressure and cholesterol, which in turn makes cardiovascular disease more likely.

But studies have also shown that a minority of Type 2 diabetics — perhaps 15 to 20 percent — are neither overweight nor obese, a phenomenon that researchers do not fully understand.

http://well.blogs.nytimes.com/2012/08/08/diabetes-and-the-obesity-paradox/?_r=0


This report summarizes the results of that analysis, which indicated that most adults with diagnosed diabetes were overweight or obese. During 1999--2002, the prevalence of overweight or obesity was 85.2%, and the prevalence of obesity was 54.8%.


http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5345a2.htm

[PoliticAverse]

3. Why do mice seem to get the best healthcare?... n/t

[MADem]

8. Ha ha ha!!! That's a thread winner! nt

[LittleGirl]

5. One drug

can't make up for all of the chemicals they are putting in our food supply. And humans aren't mice and we have emotional eaters and junk food that is addicting to some people. Like Doritos. You can't eat just one of those things.

[displacedtexan]

6. Mice are mammals.

Mice, like all other mammals, have similar biological systems (e.g. respiratory, circulatory and nervous systems) and so it is expected that their response to an experimental condition would be the same in other mammals.