Increasing the activity of a single gene turns a mere rodent into Mighty Mouse, according to a new study.
California scientists have genetically engineered an animal that has more muscle, less fat and more physical endurance than their littermates. The mice go twice as far as expected. They also seem protected against the inevitable weight gain that follows a high fat, high calorie diet.
We were quite surprised," said Ronald M. Evans, a Howard Hughes Medical Institute investigator at the Salk Institute in La Jolla, Calif. "Most people think that increased endurance comes from training. But we've been able to re-create this entire exercise network by increasing the activity of a single protein."
Evans said that the findings could have implications for human athletes and others who shy away from exercise despite the known benefits for the cardiovascular system, the muscles and bones, and even the brain. "While it could be used for patients who can't exercise, it could also be abused by athletes to enhance performance," said Evans.
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