In general, I think "giant air bubbles" are not something most people aim for with bread. You aim for an even crumb, which comes from good kneading and gluten development. (Sorry, but I've not gotten on that no-knead bandwagon that seems so big here--strictly a traditionalist.) Big holes means you've had weak areas where the gas went nuts.
That being said, you can cultivate them by allowing plenty of time for your dough to ferment. In my experience, the best way to do that is to have a really wet dough and let it rise low and slow. I discovered a while ago that this is actually desirable on occasion. Used to make a foccacia all the time (for pizza dough as well as foccacia or breadsticks), but stumbled across
a recipe for ciabatta that I tweaked for WW flour and has now become THE everyday bread for those purposes. It's light and airy and crisps up nicely. No real secret to doing it well, either. I simply use about a 1:1 ratio of flour to water (this can vary because I always use whole grain flour and the bran can vary in how much it can accommodate), a little salt, a little yeast, maybe a bit of olive oil--and then I beat the daylights out of it. This is the one bread I have to use the mixer for because it's so soft. By the time you let your KitchenAid pummel it for 10-15 minutes, it starts to look like something that might come together. Then you cover it, leave it in a cool place, and walk away for a few hours. When you come back, it will have come together more. You scrape it out onto a well-floured board and just kind of scoop it in on itself a few times. It will hold its shape, surprisingly. From there, I dump it on parchment on my peel and give it another rise (this can be warmer), then proceed as usual (i.e. poke it with fingertips to hold the olive oil and goodies or simply top with your favorite pizza toppings).
It is to die for. Even people who aren't crazy about the chewiness of WW pizza crust admit this is amazing. If holes are what you crave, this is the bread for you. :)