was thrown back on his heels. He told the owner that he didn't know what to make of it.
He went in to remove one of the tumors for further tests (only 10 days or so after the woman had started to use the SOD), and he said it just crumbled in his fingers. Apparently all the blood supply or whatever feeds a tumor was shut down. Now that's remarkable!
And please trust me that this woman is not someone who exagerates or makes things up. She's very pragmatic and has been the owner and caretaker for many animals all her life. She's seen it all.
When her pet got sick she simply did a lot of research on this subject.
There are bound to be more stories like this on the internet. I just haven't found them
yet. Thanks for helping me research this a bit.
These are tests for humans cancers, but they are being done on animals. Unfortunately, I've very little understanding of all these medical terms. But the gist of it seems to indicate that there is definitely an effect on tumor growth.
There are almost no special histopathological characteristics or criteria that exactly define a malignant pheochromocytoma. Tissue concentrations of catecholamine metabolites and superoxide dismutase activity have been proposed as possible candidates for discriminating between benign and malignant pheochromocytomas. Tissue concentrations of dihydroxyphenylalanine, metanephrine, normetanephrine, vanillylmandelic acid, and 3-methoxy-4-hydroxyphenylethylglycol were determined in 29 normal adrenal medullas, 13 benign pheochromocytomas and 6 malignant pheochromocytomas, respectively. The copper-zinc superoxide dismutase and manganese superoxide dismutase activities in remnants of these tissues were determined by interruption of nitric formation from hydroxylamines. Catecholamine metabolites and copper-zinc superoxide dismutase activity in benign and malignant pheochromocytomas were identical. Manganese superoxide dismutase activity in malignant pheochromocytoma was the lowest among the groups examined.
http://linkinghub.elsevier.com/retrieve/pii/S0022534701673063Introduction of a normal human chromosome 6 into human melanoma cell lines results in suppression of tumorigenicity. This suggests that a gene(s) on chromosome 6 controls the malignant phenotype of human melanoma. Because antioxidants can suppress the tumor-promotion phase of carcinogenesis, and because the antioxidant enzyme manganese superoxide dismutase (MnSOD) has been localized to a region of chromosome 6 frequently lost in melanomas, we have examined the effect of transfecting sense and antisense human MnSOD cDNAs into melanoma cell lines. Cell lines expressing abundant (+)-sense MnSOD-5 cDNAs significantly altered their phenotype in culture and lost their ability to form colonies in soft agar and tumors in nude mice. In contrast, the introduction of antisense MnSOD or +psv2neo had no effect on melanoma tumorigenicity. These findings indicate that stable transfection of MnSOD cDNA into melanoma cell lines exerts a biological effect that mimics that observed after introduction of an entire human chromosome 6.
http://www.pnas.org/content/90/7/3113.abstractOverexpression of Manganese Superoxide Dismutase Suppresses Tumor Formation by Modulation of Activator Protein-1 Signaling in a Multistage Skin Carcinogenesis Model
http://cancerres.aacrjournals.org/cgi/content/abstract/61/16/6082Results on hamsters:
http://www.znaturforsch.com/ac/v55c/55c0649.pdf
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