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Interesting renal failure studies in humans - similarities to melamine incident...

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kestrel91316 Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Apr-07-07 06:47 PM
Original message
Interesting renal failure studies in humans - similarities to melamine incident...
One of the vets at VIN has been sleuthing!

~~~~~~~~~~~~~~~~~
An article from 2005 showing that ARF cases in people are on the increase for unknown reason.....

Retrospective Analysis on Chinese Patients Diagnosed with Acute Renal Failure Hospitalized during the Last Decade (1994-2003)
Yue Wang, Zhuan Cui, Minhua Fan

Department of Nephrology, Peking University Third Hospital, Beijing, PR China

Address of Corresponding Author

American Journal of Nephrology 2005;25:514-519 (DOI: 10.1159/000088460)

Objectives: To investigate the epidemiology, diagnosis and prognosis of acute renal failure (ARF) in hospitalized Chinese during the last decade. Methods: The diagnosis of patients with ARF in Peking University Third Hospital from January 1994 to December 2003 was reconfirmed and the data of epidemiology, etiology and prognosis were analyzed. Results: Only 209 discharged cases were diagnosed with ARF and all were reconfirmed. Two peak occurrences were found at ages of 35-45 and 60-80 with a male predominance of approximately 59.7%. Patients diagnosed with ARF accounted for 1.19 of the admissions in the same period and increased significantly in the last 5 years (p = 0.038). The creatinine level at diagnosis was 345.8 ± 122.6 µmol/l and had no significant change (p > 0.05). The percent of hospital-acquired ARF (HA-ARF) demonstrated a significant increase in 1999-2003 compared to 1994-1998 (p = 0.008). Intrarenal ARF accounted for 73.69% and was multifactorial, with drugs, infections and operations as leading causes(... )The overall mortality was 37.91% without improvement over time. The mortality was 6.25% for patients in nephrology department, but 65.51% in ICU (p < 0.001), and was 21.6% for patients in community-acquired ARF (CA-ARF), but 63.1% in HA-ARF (p < 0.001). Conclusions: During the past 10 years, the number of patients diagnosed with ARF has been rising in hospitalized Chinese. HA-ARF was the major source, and infections, drugs and operations were the leading causes. ...

Copyright © 2005 S. Karger AG, Basel

Author Contacts

Dr. Yue Wang
Department of Nephrology
Peking University Third Hospital

~~~~~~~~~~~~~~~~~~

Interesting article on epidemic of PEDIATRIC ARF in humans in Haiti that was linked to contaminated glycerin in cough medicine--- glycerin came from China, (1996). Glycerin was contaminated heavily w/ diethylene glycol.

JAMA. 1998;279:1175-1180.

Context.— Contaminated pharmaceutical products can result in substantial morbidity and mortality and should be included in the differential diagnosis of deaths of unknown origin.

Objective.— To investigate an outbreak of deaths among children from acute renal failure in Haiti to determine the etiology and institute control measures.

Participants.— Cases were defined as Haitian residents younger than 18 years with idiopathic anuria or severe oliguria for 24 hours or longer. Febrile hospitalized children without renal failure were enrolled as control subjects.

Main Outcome Measure.— The odds of exposure to suspected etiologic agents among cases and controls.

Results.— We identified 109 cases of acute renal failure among children. The clinical syndrome included renal failure, hepatitis, pancreatitis, central nervous system impairment, coma, and death. Of 87 patients with follow-up information who remained in Haiti for treatment, 85 (98%) died; 3 (27%) of 11 patients transported to the United States for intensive care unit management died before hospital discharge. A locally manufactured acetaminophen syrup was highly associated with disease (odds ratio, 52.7; 95% confidence interval, 15.2-197.2). Diethylene glycol (DEG) was found in patients' bottles in a median concentration of 14.4%. The median estimated toxic dose of DEG was 1.34 mL/kg (range, 0.22-4.42 mL/kg). Glycerin, a raw material imported to Haiti and used in the acetaminophen formulation, was contaminated with 24% DEG.

Another article about same>>>>
In this issue of JAMA, O'Brien and colleagues2 take us to the dark wood of a public health disaster: the contamination of a medication, acetaminophen, with a toxic chemical, diethylene glycol (DEG), which occurred in Haiti in 1995 and 1996. Composed of 2 ethylene glycol residues joined by an ether bond, DEG has many industrial uses as a humectant, plasticizer, antifreeze, and solvent. In the confiscated medicines tested in Port-au-Prince, the median DEG concentration was 14.4%; a trace-back investigation revealed formulation of the syrups using glycerin of Chinese origin that was contaminated with 24% DEG

~~~~~~~~~~~~~~~~~~

Can somebody PLEASE explain to me why we are letting China get away with this???

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ret5hd Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Apr-07-07 06:49 PM
Response to Original message
1. Because China owns us.
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Skidmore Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Apr-07-07 06:54 PM
Response to Reply #1
3. And the freetraders on both sides of the aisle have sold us out.
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Joanne98 Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Apr-07-07 06:50 PM
Response to Original message
2. SEND TO LOU DOBBS! K&R!
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jakem Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Apr-07-07 06:59 PM
Response to Original message
4. I don't get it.
Edited on Sat Apr-07-07 07:05 PM by jakem
The ARF article stated the major increase was in 'hospital induced' ARF, meaning I presume drug-induced causes primarily.

The Glycerine article is hopefully an unfortunate and isolated incident, and not so different from our homegrown contaminations (see heading 'peanut butter')

China's growth and limited manufacturing oversite is not without problems for sure, but I am not so sure it is the big bad wolf...

could we sent Nader over?
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WiseButAngrySara Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Apr-07-07 07:24 PM
Response to Reply #4
6. I noticed that too... hiospital acquired ARF is not likely due
to food chain contaminants.
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kestrel91316 Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Apr-07-07 07:50 PM
Response to Reply #4
9. Maybe in the hospitals in CHina they feed everybody lots of SEITAN??
:shrug:
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WiseButAngrySara Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Apr-07-07 07:21 PM
Response to Original message
5. Remember the recent Monsanto thread where you mentioned
antibiotic residues? China is a big culprit wrspt. antibiotic residue contaminants in honey, milk, and fish and meat products.

http://www.democraticunderground.com/discuss/duboard.php?az=show_mesg&forum=389&topic_id=585858&mesg_id=586972

http://news.bbc.co.uk/2/hi/health/1829926.stm
The Food Standards Agency (FSA) is calling for the withdrawal from sale of all jars of Chinese and blended honey.
Tests were carried out following concerns about a lack of control on the use of veterinary drugs in China.
They revealed traces of an antibiotic called chloramphenicol in ten out of 16 samples.
In larger doses chloramphenicol can cause cancer.
It is also considered a contributory factor in developing aplastic anaemia, a rare but serious blood disorder that affects 50 to 100 people a year in the UK.
A team of independent scientific experts convened to assess the risk to the consumer concluded that it was extremely small.
The FSA's advice is that people can continue to eat any honey they have already bought, irrespective of country of origin.
It is estimated that between a third and a half of all blended honey on sale in the UK comes from China. Approximately 80% of honey consumed in the UK is blended.
A spokeswoman for the FSA said: "We are not saying don't eat Chinese and blended honey, because there is an extremely low risk.
"But we are saying chloramphenicol is illegal and undesirable so we are calling for the withdrawal of Chinese and blended honey."
Retailers
The Honey Association has advised all its members to withdraw any blends containing Chinese honey from sale, and to seek alternative sources of honey until acceptable standards of monitoring are introduced in China.
In a statement, the association said: "This will obviously have pricing implications throughout the industry, but it is of paramount importance to all members to maintain consumer confidence in honey overall as a natural, energy-giving food."
All existing stocks of Chinese honey in the UK will now undergo very stringent tests and will only be released for production if they fully comply with the EU standards.
The voluntary testing programme will also apply to industrial blends containing Chinese honey (which are often blended in production), as well as shipments from China already on the sea when the EU suspension was put into effect.
http://www.apimondia.org/apiacta/articles/2005/michaud_1.pdf
http://www.iol.co.za/index.php?set_id=1&click_id=117&art_id=vn20070328115557290C460795

Honey leaves a bad taste in the mouth

March 28 2007 at 04:36PM

By Maureen Marud

No honey imported from China has ever been stocked by Woolworths and the Shoprite Group, and Pick 'n Pay is asking all its suppliers to verify that their honey is uncontaminated.

The three biggest supermarket chains were quick to react to the news that countless litres of Chinese honey already consumed in South Africa in the past four years were contaminated with a dangerous antibiotic residue suspected of causing liver cancer and a potentially fatal rare blood disorder.
But local beekeepers, who say their honey has never been contaminated with any potentially toxic substance, claimed Chinese honey was still coming into South Africa without being tested for residues.

"Not all honey imported from China is contaminated," said Nico Langenhoven, former chairman of the South African Bee Industry Organisation.

"I have had three imported batches tested by the South African Bureau of Standards and no antibiotic residue was found," said Langenhoven.

"But there has been a negative perception about Chinese honey ever since 2002, when the European Union banned its importation for two years, and the United States and Canada followed suit."

Those countries stopped imports of Chinese honey after the chloramphenicol residue of the neo-terramycin antibiotic was found in the honey. The antibiotic is used to treat bees for disease, but many Chinese producers are believed to overdose even healthy hives as a preventative measure, leaving potentially toxic traces in the honey harvest.

http://www.fst.vt.edu/extension/drg/dfax/August06.html
China 's New Standard on Antibiotic Residues
China currently has around 12 million cows producing 3 tons of milk each per year. The Chinese are estimated to consume about 18kg of dairy produce per capita. The consumption of dairy products in China has grown rapidly in the last 30 years, prompting an increasing drive for food safety and consumer health. The Ministry of Agriculture has drawn up a new national standard on raw milk that will make testing for antibiotics in raw milk compulsory for dairy processors.
Antibiotics are widely used by Chinese dairy farmers to treat infections in their dairy herds and previously, there has been no regulation in place to restrict their use. A recent survey has shown that around 50 percent of milk products on the market contain antibiotic residues. Since residues can reach the milk, people who are allergic to specific antibiotics are at risk. Also, frequent exposure to low level antibiotics can cause microorganisms to become resistant to them, through mutation, so that they are ineffective when needed to fight a human infection.

http://europa.eu/rapid/pressReleasesAction.do?reference=IP/02/1351&format=HTML&aged=1&language=EN&guiLanguage=en

China
Following the detection of the antibiotic chloramphenicol in certain aquaculture and fishery products imported from China, and shortcomings identified during a Commission inspection visit to China, imports of products of animal origin from China were suspended in March this year (IP/02/143). At that time, the decision said that this would be reviewed in the light of further information provided by the Chinese authorities and the results from increased testing carried out by Member States on consignments arriving before 14 March. In May, (IP/02/693), in the light of information provided by the Chinese authorities, and the favourable results of the tests carried out, the imports of certain fish products, gelatine, and sausage casings were resumed, subject to increased monitoring and testing to ensure their safety.
In view of the favourable results of the test carried out on fish products during recent months, it was decided today that re-enforced testing is no longer required for whole fish, gutted and de-headed fish and fish fillets of the following species: Alaska pollack, cod and redfish, Blue Whiting, Halibut, Haddock, Herring, Yellowfin sole, Cephalopods, Plaice, Pacific salmon and fillets of salmon. Reinforced testing is maintained for sausage casings.
http://www.dairyreporter.com/news/ng.asp?n=69604-business-news-aqsiq-antibiotic-dairy-china
China to clamp down on antibiotics in milk

By Francis Yang
03/08/2006- China is preparing to launch a new national standard on raw milk to prevent dairy products containing antibiotic residues from reaching the marketplace.

According to a report in Shanghai-based newspaper China Business News this week, a new national standard on raw milk, which has been drawn up by the Ministry of Agriculture, is waiting to be approved by the Standardization Administration of China. It will make the testing of antibiotics and flavacol M1 in raw milk compulsory for dairy processors.

The move shows the increasing drive for food safety and consumer health in China, where consumption of dairy products has grown rapidly in the last 30 years.

Antibiotics are widely used by Chinese dairy farmers to treat infections in their dairy herds and there is no regulation in place to restrict their use. But residues of these drugs can reach a cow's milk and therefore, the human foodchain.

A survey conducted by China's food safety authority AQSIQ in the first half of this year showed that around 50 per cent of milk products on the market contained residues of antibiotics, said the paper.

This can be dangerous for people who are allergic to specific antibiotics. Also, frequent exposure to low level antibiotics can cause microorganisms to become resistant to them, through mutation, so that they are ineffective when needed to fight a human infection.

In other countries, cows given antibiotics are typically withheld from the milk supply for some days and both farmers and dairy processors carry out routine testing for antibiotics, with serious penalties for those found to be selling milk containing residues. But in China's major dairy regions, where milk is collected from thousands of small dairy farmers, testing for antibiotics is not standard practice.



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NNN0LHI Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Apr-07-07 07:25 PM
Response to Original message
7. I bet the number of ARF cases has really shot up in Iraq since we invaded and began feeding them n/t
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DBoon Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Apr-07-07 07:49 PM
Response to Original message
8. Because there are no tort attorneys in China
You get rid of law suits, you have a legal system where victims CANNOT seek compensation, you get this sort of nonsense.

Getting rid of trial lawyers is one way to make use more like China.

Note that I am making assumptions about the Chinese legal system - I seriously doubt it is based on English Common Law, though

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PhilipShore Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Apr-07-07 08:01 PM
Response to Original message
10. Power games
Can somebody PLEASE explain to me why we are letting China get away with this???

Part of the reason is "power and money" corrupts a true democracy -- and we are in debt to China.

United States public debt
From Wikipedia, the free encyclopedia

The country holding by far the most U.S. debt is Japan which held $644.3 billion at the end of December 2006. In recent years the People's Republic of China has also become a holder of over $1 trillion in total foreign reserves, of which about $349.6 billion are U.S. Treasury securities. Source:

The mechanics of U.S. Government debt

When the total amount of revenue collected by the U.S. Government is exceeded by the amount of money it spends (including spending on debt payments that are coming due), it issues new debt to cover the deficit. This debt typically takes the form of new issues of government bonds which are sold on the open market. However, the debt can also be monetized by which the U.S. Government sells the debt to the Federal Reserve. Monetized debt expands the money supply because these government securities become bank reserves held by the Federal Reserve that, under the system of Fractional Reserve Banking, are treated as an asset that the bank can then lend against. Because the money supply expands each time U.S. Government debt is monetized, the natural result is an inflationary boom caused by the expansion of new credit from the additional "reserves" that the Federal Reserve now has which will then result in a deflationary bust to complete the business cycle.

The ultimate consequence of monetizing U.S. debt is that it expands the money supply which will tend to dilute the value of dollars already in circulation. Thus, expanding the pool of money puts downward pressure on the dollar and upward pressure on inflation. Note that money supply expansion is not the only force at work in inflation. United States Dollars are essentially a commodity on the world market and the value of the dollar at any given time is subject to the law of supply and demand. In recent years, the debt has soared and inflation has stayed low in part because China has been willing to accumulate reserves denominated in U.S. Dollars. Currently, China holds over $1 trillion in dollar denominated assets (of which $330 billion are U.S. Treasury notes). In comparison, $1.4 Trillion represents M1 or the "tight money supply" of U.S. Dollars which suggests that the value of the U.S. Dollar could change dramatically should China ever choose to divest itself of a large portion of those reserves. Source:

http://en.wikipedia.org/wiki/U.S._public_debt
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shance Donating Member (1000+ posts) Send PM | Profile | Ignore Sat Apr-07-07 08:17 PM
Response to Original message
11. Why has it been allowed to happen here with our animals is the much better question I think.
n/t
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