Update:. Getting Moderna Vaccine (or Saline solution) on Tuesday

[Drahthaardogs]

It's official DU'ers. I get injected Tuesday morning at 9:15. mRNA vaccine - if I'm lucky! Saline solution if I'm not.

So excited! Send me prayers, vibes, kabooki wishes! 50/50 I get the vaccine. I am so hoping I catch a break and get the real stuff!

[SheltieLover]

1. Vibes to you 💗💗💗

🤞🤞🤞🤞🤞

[elleng]

2. THANKS!

[soothsayer]

3. Vibes for whichever outcome is best!

[crickets]

4. Good for you for doing this. Super positive vibes headed your way!

[Hoyt]

5. Thanks and good luck. Even if you get a placebo, you are a pioneer.

[moonscape]

6. Yay! Hope you get the real thing and that the

results for this trial turn out to be spectacular! Thanks for participating for all of us.

[rurallib]

7. good luck and thank you

[Gilbert Moore]

8. Thank You

I hope all works well and you get a winner !

[SergeStorms]

9. You'll be able to tell the difference.

Even flu vaccines feel like molten lead being injected into your arm. The vaccination site is usually a little tender for a few days as well. I wouldn't expect that with a saline injection. But........who knows for sure, right? Good luck in either case. Thanks for being the U.S. Guinea Pig.

[ProfessorGAC]

20. I Suppose They Could Add...

...a tiny amount of capsaicin. That would burn a bit going in, and subdermal inflammation would cause some soreness.
And, it would be safe, as 90%+ of capsaicin is just pepper extract. We can synthesize it, but that costs more than using peppers.
I don't know they do this, but I think they could so it would be harder to tell which injection you received.

[MLAA]

10. Good luck getting the real thing baby!

[safeinOhio]

11. Good for you.

I think if trial works, the control group will get the real one right away. Win, win.

[Dorian Gray]

12. Ooh!

Good luck and thank you for your service!

[DesertRat]

13. Thank you!

Sending you love, hugs and prayers!

[eppur_se_muova]

14. Whichever one you get, I hope it turns out to be effective. ;)

I signed up to participate in a vaccine trial, but before I got the call to make an appointment I found myself suddenly my mother's only caretaker, so I felt like it was too big a risk after that. Would have been nice to tell folks someday that I helped develop the vaccine, even if only a little bit, but it didn't work out.

[JDC]

15. Thank you. Good Vibes!

[wendyb-NC]

16. Best wishes,good vibes and positive energy to you.

[Iggo]

17. So, how does that work?

Is it that they know the vaccine kills the virus and they’re just seeing if it’s safe for humans?

Or do they see if you’re okay from the injection, and then move on to exposing you to the virus?

Honestly, I never actually thought it through before.

[myccrider]

22. Here's a couple of links

I went looking for a detailed explanation when I saw your question. Although I have a rough idea of how the process works, I was also curious about the nitty-gritty.

I was thinking this was the next-to-last trial needed for approval but I was wrong. This is the final test before approval, at least according to the link below.

Here’s an A-B-C of how vaccines are tested and approved:
https://www.historyofvaccines.org/content/articles/vaccine-development-testing-and-regulation

Here’s a link to NIH announcement about this Phase 3 trial (ignore the obligatory brown-nose comment about Trump from Azar):
https://www.nih.gov/news-events/news-releases/phase-3-clinical-trial-investigational-vaccine-covid-19-begins

"The trial is designed to evaluate the safety of mRNA-1273 and to determine if the vaccine can prevent symptomatic COVID-19 after two doses. As secondary goals, the trial also aims to study whether the vaccine can prevent severe COVID-19 or laboratory-confirmed SARS-CoV-2 infection with or without disease symptoms. The trial also seeks to answer if the vaccine can prevent death caused by COVID-19 and whether just one dose can prevent symptomatic COVID-19, among other objectives."

This paragraph was confusing, though.
"Volunteers must provide informed consent to participate in the trial. They will be asked to provide a nasopharyngeal swab and a blood sample at an initial screening visit and additional blood samples at specified time points after each vaccination and over the two years following the second vaccination. Scientists will examine blood samples in the laboratory to detect and quantify immune responses to SARS-CoV-2." [my bolding]

I don’t think they’re planning on waiting 2 years to approve the vaccine if the initial results are positive. That makes me a bit nervous because the combo of the pandemic and Mangolini’s desperation about re-election means the pressure to cut corners and get something out to the masses may overwhelm safe and correct scientific procedure.

Being in one of the more vulnerable populations, I’m going to be very wary of getting a vaccine until it’s thoroughly vetted.

[Iggo]

23. Wow! Thank you.

I just spent a good half hour reading through a bunch of that. (Had to quit because I’m wearing the wrong glasses and I didn’t want to strain my eyes. Bifocals. One of these days. Bifocals.)

But really good basic information.

Thanks again!!!

[myccrider]

24. You're welcome. I learned, so thanks for the question. n/t

[DeminPennswoods]

25. Phases 1 and 2 were for safety assessment

Moderna's vaccine passed those, that's why it moved to Phase 3.

I'm not sure how the volunteers were selected, but I'd guess they'd prefer them to be from places that are seeing a lot of cases otherwise they'd be less likely to be exposed, setting the trial back. That's what happened to the vaccine beind developed at Oxford, the cases were low in England/UK and researchers were worried the vaccine volunteers wouldn't be exposed to cv19. IIRC, those vaccine test volunteers are being deliberately exposed to cv19 in the lab.

I don't think it's unusual for researchers to do follow ups on the test subjects. I'm sure they want to know how long the antibodies last, if there are memory T cells and other important data no one has right now.

[Illumination]

18. You're a trail blazer for sure! Hope you have all your papers in order...just in case!

[myccrider]

19. Thank you! n/t

[ProfessorGAC]

21. Good Luck, D!

Volunteering as a subject is very cool of you!

[DeminPennswoods]

26. Thanks!

You are a pioneer for sure.

[JustABozoOnThisBus]

27. I hope the shot hurts for days. I hope it causes you a fever.

If so, you didn't get saline.



Edit to add: If no pain and no fever, it means nothing. Still 50/50 that you got the vaccine.