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Hugin

(33,059 posts)
1. I've been careful about anything that could hinder the effectiveness of the vaccine.
Mon Apr 5, 2021, 10:15 AM
Apr 2021

I am also worried about an antihistamine I take regularly.

I'm not going to click on the link, but, does it say anything about the class of pain killers which is of most concern? NSAIDs? ACETAMINOPHEN?

SoCalNative

(4,613 posts)
2. I have read elsewhere
Mon Apr 5, 2021, 10:18 AM
Apr 2021

no Tylenol , Advil or Aleve and that you should not take an antihistamine prior to the shot as it could mask the signs of an allergic reaction to the vaccine.

Hugin

(33,059 posts)
3. Interesting.
Mon Apr 5, 2021, 10:23 AM
Apr 2021

Probably accurate.

Personally, I'm not inclined to worry about that for myself, as I've regularly gotten various vaccinations and even allergy shots with no problems.

Then there's food supplements and vitamins (specifically, vit C) which are widely taken by people right now that could have the same problem.

central scrutinizer

(11,637 posts)
4. The NYTimes wrote about this yesterday
Mon Apr 5, 2021, 10:55 AM
Apr 2021

Excerpt:

Q: What about taking a pain reliever after the shot?

“It’s OK to treat” side effects with a pain reliever, said Dr. Offit, but if you don’t really need one, “don’t take it.”

While most experts agree it’s safe to take a pain reliever to relieve discomfort after you get vaccinated, they advise against taking it after the shot as a preventive or if your symptoms are manageable without it. The concern with taking an unnecessary pain reliever is that it could blunt some of the effects of the vaccine. (In terms of the vaccine, there’s no meaningful difference if you choose acetaminophen or ibuprofen.)

During the Moderna trial, about 26 percent of people took acetaminophen to relieve side effects, and the overall efficacy of the vaccine still was 94 percent.

 

Laura PourMeADrink

(42,770 posts)
5. That's so interesting. Yes, not the end of the world if you take
Mon Apr 5, 2021, 11:24 AM
Apr 2021

But still strikes me this should be info that is readily available to people. If people knew that efficacy could be even marginally better why not avoid?

 

Laura PourMeADrink

(42,770 posts)
9. My SIL has been managing drug trials for years. She read the
Mon Apr 5, 2021, 11:40 AM
Apr 2021

protocol studies for the vaccines and they did not mention pain relievers. She said that means there was no data collected on effects of combining.

Hortensis

(58,785 posts)
8. I was advised to delay vaccination as long as I felt comfortable
Mon Apr 5, 2021, 11:36 AM
Apr 2021

while a steroid medication was tapered down. Because it was believed to lessen efficacy.

Celerity

(43,124 posts)
10. We were told not to take anything unless absolutely necessary, and then to call the study hotline
Mon Apr 5, 2021, 11:41 AM
Apr 2021

first.

Perhaps the trial nature of our experimental vax dictated this. I shall ask on Friday when we get our first post vax blood draw.

 

Laura PourMeADrink

(42,770 posts)
12. Post vax blood draw because you were in the study, right? I was
Mon Apr 5, 2021, 12:07 PM
Apr 2021

Just thinking it would be interesting for individuals to see their individual immunity level post vaccine.

Celerity

(43,124 posts)
14. Yes, we are in the Moderna mRNA-1273.351 variant tweaked vax
Mon Apr 5, 2021, 12:34 PM
Apr 2021

trial at Karolinska universitetssjukhuset here in Stockholm. We also have been in a long term immunity study since May 2020, after we both caught the original strain (we were asymptomatic) end of April 2020 or so. Our antibody, T helper, T killer, and B cell counts remained high the whole time. Our almost 11 month participation in the original study, plus our profiles are what got us 2 places in the mRNA-1273.351 trials. That and we agreed to a lot of waivers, far beyong normal, as the vax is highly experimental and carries large potential risk when taken at the doses we both are. Different cohorts in the study got different combos. We got pure variant vax only, and at the max level administered for this study. Many got combo vaxxed, original plus mRNA-1273.351. Since we already had iriginal stain COVID and still had high immunity counts, we are in the variant only cohort.

Other than sore arms for around 16 or so hours, we had no reaction to the vax.

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