Cannabis compounds stopped COVID virus from infecting human cells in lab study

[packman]

Forget about bleach, horse de-wormer and/or drinking urine - try pot----

Cannabis compounds prevented the virus that causes COVID-19 from penetrating healthy human cells, according to a laboratory study published in the Journal of Nature Products.

The two compounds commonly found in hemp — called cannabigerolic acid, or CBGA, and cannabidiolic acid, or CBDA — were identified during a chemical screening effort as having potential to combat coronavirus, researchers from Oregon State University said. In the study, they bound to spike proteins found on the virus and blocked a step the pathogen uses to infect people.

The researchers tested the compounds’ effect against alpha and beta variants of the virus in a laboratory.


https://fortune.com/2022/01/12/cannabis-compounds-stop-covid-virus-infecting-human-cells-lab-study/

[mbusby]

1. Time to ....

.... fly low over desert canyons.

[Initech]

2. Wouldn't that be great if the cure for this thing was found in nature the whole time?

[James48]

3. I'll add that to my daily routine.

Thanks for the update.

[KS Toronado]

37. Please do your daily routine correctly......

Found this after a little searching......

Smoking cannabis does not offer any protection from the virus that causes COVID-19.

"The benefit for preventing viral infection of cells must come from cannabinoid acids, which are heat sensitive and must not be smoked, or it would convert them to CBD and so forth," van Breemen said. "So that wouldn't work for the antiviral effect."

The study tested the effectiveness of the compounds against the original, alpha and beta strains of SARS-CoV-2, according to the news release, but not more recent variants such as delta and omicron.

"I don't think the compounds in hemp are the answer to the pandemic, but rather part of the solution," van Breemen said.

https://www.kgw.com/article/news/health/coronavirus/osu-study-hemp-compounds-block-coronavirus/283-456392dc-8006-4e3f-8a88-71cdd5e460d1

So, rolling a doobie up doesn't help but CBD might

[XacerbatedDem]

44. But gummies are OK, right?

[KS Toronado]

46. I believe gummies contain the "cannabinoid acids"

A little WWW search on gummies should reveal a lot on the subject. And welcome to DU!

[XacerbatedDem]

47. Thank you

[Strelnikov_]

51. Vape

But probably a one or two and done, as my understanding is the cannabinoids are gone fairly quickly.

[Roisin Ni Fiachra]

53. Cannabinoids: Beyond THC and CBD

Tetrahydrocannabinolic Acid (THCA) is the precursor to THC and found in high concentrations in cannabis flower. When heated, THCA becomes decarboxylated, creating THC. Unlike THC, THCA is not intoxicating, but it can still have powerful anti-nausea effects.

Similar to THCA, Cannabidiolic Acid (CBDA) is the precursor to CBD found in cannabis flower. CBDA is typically found in higher concentrations in hemp. When heated, CBDA is converted to CBD. One study showed that CBDA inhibits cell migration in aggressive breast cancer.

· Cannabinol (CBN) forms when THC is degraded and is often found in older cannabis plants. When combined with THC, CBN is highly sedative. That’s why timing your cannabis harvest is crucial to getting the right effect. Studies have demonstrated that CBN has anticonvulsant, anti-inflammatory, and antibacterial effects.

· Cannabigerol (CBG) is a pretty amazing compound. The acid form of CBG, CBGA, is the precursor to THCA, CBDA, and many other phytocannabinoids. It’s also a strong anti-bacterial agent and has potential as an analgesic and antidepressant.

https://www.encore-labs.com/cannabinoids-beyond-thc-and-cbd

Many CBD products are isolates, ie pure CBD, without the precursor cannabinoids. Full spectrum/Broad spectrum CBD products may contain the precursor cannabinoids that block Covid, but the question here is, do they contain sufficient amounts of these precursor cannabinoids to block the virus after ingesting them? I have found CBD to be good medicine for certain purposes, but it may not be effective against Covid.

Whatever the case, many studies should be undertaken immediately to first identify all the most effective Covid blocking cannabinoids, and the effective dosages necessary for ingesting them in order to block Covid.

I can't help but wonder if pharmaceutical companies are already obstructing the research of cannabinoids and their effectiveness in blocking the virus from en.tering human cells.

[intheflow]

4. Perhaps this explains why I just tested negative after

my housemate tested positive.

[Solomon]

50. I was about to say, no wonder I haven't caught the covid!

[dweller]

5. Maybe the government

should send every household some of the good stuff they’re holding ?
🤔


✌🏻

[Raftergirl]

6. Bob Dylan knew this decades ago, 😉

[Mysterian]

7. Marijuana proves God loves us

or else we just got really lucky with plant evolution.

[Traildogbob]

17. Just like

Ron Johnson said. God gives us everything we need. Use pee as bong water. Bam! Cured.

[2naSalit]

8. Could be why...

I'm not sick, that and the vaccine/booster!

[calimary]

12. I was just thinking that, too!

That, and the vaccinations/boosters.

[2naSalit]

13. Damn right.

[alittlelark]

9. Phew.. !!!!

I'm Safe !!!!

[NightWatcher]

10. I continue to test negative....

I am a daily user.

[Mr. Evil]

11. Once again, cannibis shows its worth to humanity.

[Lonestarblue]

22. But we had to outlaw it because it's immoral!

We have some terrible laws because of religion! The country’s leaders should have learned from Prohibition that it’s better to tax substances like alcohol and drugs than to outlaw them and create a black market that only leads to crime. When a minority view of morality guides lawmaking, as in banning all abortion, things tend to go awry.

[hot2na]

14. Works or me!

[SpankMe]

15. Snoop Dogg must be immune, then

But, any journal with the word "Products" in it's title pretty much takes away all credibility, in my opinion.

[SCantiGOP]

16. I hope this is true

but it does sound like something two stoners would come up with after one too many bong hits

[rurallib]

18. This would just be way too karmic!

I so hope it is true.

I do not indulge, but I would for science, Yes I would.

[Red Pest]

19. Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants (link below)

[link:https://doi.org/10.1021/acs.jnatprod.1c00946|

Abstract:

As a complement to vaccines, small-molecule therapeutic agents are needed to treat or prevent infections by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its variants, which cause COVID-19. Affinity selection–mass spectrometry was used for the discovery of botanical ligands to the SARS-CoV-2 spike protein. Cannabinoid acids from hemp (Cannabis sativa) were found to be allosteric as well as orthosteric ligands with micromolar affinity for the spike protein. In follow-up virus neutralization assays, cannabigerolic acid and cannabidiolic acid prevented infection of human epithelial cells by a pseudovirus expressing the SARS-CoV-2 spike protein and prevented entry of live SARS-CoV-2 into cells. Importantly, cannabigerolic acid and cannabidiolic acid were equally effective against the SARS-CoV-2 alpha variant B.1.1.7 and the beta variant B.1.351. Orally bioavailable and with a long history of safe human use, these cannabinoids, isolated or in hemp extracts, have the potential to prevent as well as treat infection by SARS-CoV-2.

Enjoy! (pun intended).

[Ford_Prefect]

20. Who's ready to write that NIH research grant proposal for this one??????

[IcyPeas]

21. hmmm... would this include gummies

[lark]

23. Well, I can tell you from personal experience that regular pot doesn't stop Covid.

My son (a wake & bake pot smoker) was living with us last year and got Covid at work. I got it from him and I smoke pot too.

[jcgoldie]

24. Looks like time to "do my own research"

Ala Aaron Rodgers...

[SleeplessinSoCal]

25. Anecdotally, I know a nurse, who loves her pot, got Covid

[Chakaconcarne]

26. Maybe this could push it toward nationwide legalization.

[Reader Rabbit]

27. Would this include both THC and CBD products?

I use CBD gummies to help me sleep sometimes, and it would be awesome if they had that side benefit.

[tavernier]

28. Hold off on the partying.

My SIL and granddaughter, daily smokers and gummy users , both got Covid last year. Both vaccinated as well. SIL required monoclonal antibodies.

[yaesu]

33. As someone in the field just told me there are many compounds that will do the same as those

mentioned, The trick is how does one delivery the compound safely in vivo. Smoking & eating probably isn't the way to deliver those compounds, the eggheads will have to figure it out.

[iscooterliberally]

29. Awesome! Between this and the booster shots I should be bullet-proof by now!

[58Sunliner]

30. It's exiting, but how to use the compounds?

The acids are neutralized during decarboxylation, so would ingested extracts work from raw plant material, or are we talking about a nasal spray?

Phytocannabinoids: Biosynthetic Pathway
Around 113 phytocannabinoids are identified in C. sativa plant [27]. These cannabinoids are biosynthesized as carboxylic acid, with the precursor being cannabigerolic acid 1 abbreviated as CBGA (Fig. 14.1). The synthesis of CBGA is an enzymatic reaction that involves an alkylation of olivetolic acid (alkylresorcinolic acid responsible for the polyketide nucleus of the cannabinoids) with the help of geranyl pyrophosphate [28]. The CBGA formed is sequentially converted into tetrahydrocannabinolic acid 2 (THCA), cannabidioloic acid (CBDA) 3, and cannabichromenic acid (CBCA) 4 with the help of synthase enzymes (THCA synthase, CBDA synthase, and CBCA synthase) [27]. These cannabinoids, especially THCA, secrete in the storage cavity of glandular trichomes [28] and are responsible for the self-defense mechanism of the cannabis plant with its insect repellant, absorption of ultraviolet radiation, and cell death properties [28]. These acids are decarboxylated into their neutral homologous (THC, cannabidiol, and cannabichromene) by a nonenzymatic reaction involving heat or light, such as during storage or smoking (Fig. 14.1).

https://www.sciencedirect.com/topics/chemistry/cannabigerolic-acid

[mathematic]

31. I guess the problem with the horse dewormer study is that horse dewormer doesn't get you high.

Lets wait until we see some effectiveness outside of direct application to cells in a lab before we start raiding the local farm supply store for all their hemp.

[Demobrat]

32. If it sounds too good to be true.....

[samsingh]

34. let's see if the repugs pick this up instead of bleach - the cognitive dissonance

[BootinUp]

35. Weed plus caffeine equals long life

Please don’t drink urine

[musette_sf]

36. Breakfast Of Champions

[MineralMan]

38. In Vitro Studies Are Often Not Indicators for In Vivo Reality.

Truly they are not.

[SergeStorms]

39. Just about anything will kill COVID....

in the correct concentration or amounts. Remember, people saw that study where Ivermectin killed COVID? Of course the amount of Ivermectin needed would probably be enough to kill a human being, but it killed the COVID as well!

I wouldn't trust this one study for definitive answers about the efficacy of cannabis compounds defeating the COVID virus.

That said, it would be great if it was true. If we got all of our country's/world's leaders baked I believe it would be a much nicer, and mellower, world to live in.

[Baked Potato]

40. Hope this works out good. Nt

[AZSkiffyGeek]

41. This sounds like the Democratic answer to horse paste

We'll see if it's true in 5 days - I was exposed yesterday and have been smoking daily for a while.

[RandiFan1290]

48. Article says nothing about smoking.

Usually helps to read the article first.

[shanti]

42. Well, that explains it then

[DuaneT]

43. Canada did some studies last year

https://www.wthr.com/article/news/health/verify-canadian-study-found-some-cbd-strains-could-lower-chances-covid-more-research-needed/531-483039fc-e4a2-4f94-9bb1-a836905ec47a

BOTTOM LINE:
The study found promising results that certain CBD strains could lower the number of cells that the virus can infect. The researchers think this should be seen as reason for further research, not taken as fact.

This study has nothing to do with the recreational use of marijuana - and shouldn’t be an excuse for people to smoke it.

A less-entertaining headline might read that: A Canadian study found certain CBD strains could lower the chances of COVID infection - but more research is needed.

[ecstatic]

45. Caffeine can too

And natural protease inhibitors. A lot of medications also interfere with the covid-19 binding process.

[Emile]

49. There you have, everybody must get high!

[denbot]

52. duuuuude..

What's Covid?