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Fri Mar 8, 2013, 03:58 PM

Molecular Link Between the Active Component of Marijuana and Alzheimer's Disease Pathology

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562334/

Molecular Link Between the Active Component of Marijuana and Alzheimer's Disease Pathology

Abstract
Alzheimer's disease is the leading cause of dementia among the elderly, and with the ever-increasing size of this population, cases of Alzheimer's disease are expected to triple over the next 50 years. Consequently, the development of treatments that slow or halt the disease progression have become imperative to both improve the quality of life for patients as well as reduce the health care costs attributable to Alzheimer's disease. Here, we demonstrate that the active component of marijuana, Δ9-tetrahydrocannabinol (THC), competitively inhibits the enzyme acetylcholinesterase (AChE) as well as prevents AChE-induced amyloid β-peptide (Aβ aggregation, the key pathological marker of Alzheimer's disease. Computational modeling of the THC-AChE interaction revealed that THC binds in the peripheral anionic site of AChE, the critical region involved in amyloidgenesis. Compared to currently approved drugs prescribed for the treatment of Alzheimer's disease, THC is a considerably superior inhibitor of Aβ aggregation, and this study provides a previously unrecognized molecular mechanism through which cannabinoid molecules may directly impact the progression of this debilitating disease.

Keywords: Cannabinoids, Alzheimer's disease, Acetylcholinesterase

Introduction
Since the characterization of the Cannabis sativa-produced cannabinoid, Δ9-tetrahydrocannabinol (THC) (Figure 1), in the 1960's,1 this natural product has been widely explored as an anti-emetic, anti-convulsive, anti-inflammatory, and analgesic.2 In these contexts, efficacy results from THC binding to the family of cannabinoid receptors found primarily on central and peripheral neurons (CB1) or immune cells (CB2).3 More recently, a link between the endocannabinoid system and Alzheimer's disease has been discovered4 which has provided a new therapeutic target for the treatment of patients suffering from Alzheimer's disease.5 New targets for this debilitating disease are critical as Alzheimer's disease afflicts over 20 million people worldwide, with the number of diagnosed cases continuing to rise at an exponential rate.6,7 These studies have demonstrated the ability of cannabinoids to provide neuroprotection against β-amyloid peptide (Aβ toxicity.8-10 Yet, it is important to note that in these reports, cannabinoids serve as signaling molecules which regulate downstream events implicated in Alzheimer's disease pathology and are not directly implicated as effecting Aβ at a molecular level.

<snip>
Conclusion
We have demonstrated that THC competitively inhibits AChE, and furthermore, binds to the AChE PAS and diminishes Aβ aggregation. In contrast to previous studies aimed at utilizing cannabinoids in Alzheimer's disease therapy,8-10 our results provide a mechanism whereby the THC molecule can directly impact Alzheimer's disease pathology. We note that while THC provides an interesting Alzheimer's disease drug lead, it is a psychoactive compound with strong affinity for endogenous cannabinoid receptors. It is noteworthy that THC is a considerably more effective inhibitor of AChE-induced Aβ deposition than the approved drugs for Alzheimer's disease treatment, donepezil and tacrine, which reduced Aβ aggregation by only 22% and 7%, respectively, at twice the concentration used in our studies.7 Therefore, AChE inhibitors such as THC and its analogues may provide an improved therapeutic for Alzheimer's disease, augmenting acetylcholine levels by preventing neurotransmitter degradation and reducing Aβ aggregation, thereby simultaneously treating both the symptoms and progression of Alzheimer's disease.

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Reply Molecular Link Between the Active Component of Marijuana and Alzheimer's Disease Pathology (Original post)
G_j Mar 2013 OP
ChairmanAgnostic Mar 2013 #1
roody Mar 2013 #2
Blue_In_AK Mar 2013 #22
haydukelives Mar 2013 #38
devilgrrl Mar 2013 #39
Rosa Luxemburg Mar 2013 #45
TexasTowelie Mar 2013 #47
woofless Mar 2013 #51
ronnie624 Mar 2013 #70
LittleGirl Mar 2013 #53
Egalitarian Thug Mar 2013 #3
truedelphi Mar 2013 #10
RainDog Mar 2013 #60
Egalitarian Thug Mar 2013 #62
Warren Stupidity Mar 2013 #4
BainsBane Mar 2013 #6
G_j Mar 2013 #34
Dustlawyer Mar 2013 #41
Egalitarian Thug Mar 2013 #63
Recursion Mar 2013 #15
Comrade Grumpy Mar 2013 #27
JackInGreen Mar 2013 #55
mitchtv Mar 2013 #5
LineLineReply !
immoderate Mar 2013 #32
BuddhaGirl Mar 2013 #7
LiberalEsto Mar 2013 #13
cthulu2016 Mar 2013 #8
tridim Mar 2013 #12
KittyWampus Mar 2013 #37
liberal_at_heart Mar 2013 #52
KittyWampus Mar 2013 #64
tpsbmam Mar 2013 #71
RainDog Mar 2013 #61
RainDog Mar 2013 #66
cherokeeprogressive Mar 2013 #72
Uncle Joe Mar 2013 #9
tridim Mar 2013 #11
barbtries Mar 2013 #14
stlsaxman Mar 2013 #16
mitchtv Mar 2013 #33
Dryvinwhileblind Mar 2013 #17
aint_no_life_nowhere Mar 2013 #18
The Wizard Mar 2013 #57
aint_no_life_nowhere Mar 2013 #58
caseymoz Mar 2013 #19
Blue_In_AK Mar 2013 #26
caseymoz Mar 2013 #29
SemperEadem Mar 2013 #20
Loudestlib Mar 2013 #21
alfredo Mar 2013 #23
Cal Carpenter Mar 2013 #24
Indepatriot Mar 2013 #25
green for victory Mar 2013 #28
Dustlawyer Mar 2013 #43
Hestia Mar 2013 #30
napoleon_in_rags Mar 2013 #31
Auntie Bush Mar 2013 #35
SCVDem Mar 2013 #36
Zorra Mar 2013 #40
Fire Walk With Me Mar 2013 #42
G_j Mar 2013 #44
green for victory Mar 2013 #65
Fire Walk With Me Mar 2013 #68
UnrepentantLiberal Mar 2013 #46
WillyT Mar 2013 #48
L0oniX Mar 2013 #49
olddots Mar 2013 #50
padruig Mar 2013 #54
The Wizard Mar 2013 #56
RainDog Mar 2013 #59
backscatter712 Mar 2013 #67
RainDog Mar 2013 #69
Javaman Mar 2013 #73

Response to G_j (Original post)

Fri Mar 8, 2013, 04:01 PM

1. translation: To keep your brain working, stay stoned as you age.

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Response to ChairmanAgnostic (Reply #1)

Fri Mar 8, 2013, 04:06 PM

2. I'm doing my best!

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Response to ChairmanAgnostic (Reply #1)

Fri Mar 8, 2013, 06:32 PM

22. My motto.

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Response to ChairmanAgnostic (Reply #1)

Sat Mar 9, 2013, 11:53 AM

38. count me in

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Response to ChairmanAgnostic (Reply #1)


Response to ChairmanAgnostic (Reply #1)

Sat Mar 9, 2013, 01:29 PM

45. I knew that there was a purpose

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Response to ChairmanAgnostic (Reply #1)

Sat Mar 9, 2013, 02:08 PM

47. Pass it around.

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Response to TexasTowelie (Reply #47)

Sat Mar 9, 2013, 02:29 PM

51. " 'ere."

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Response to woofless (Reply #51)

Sun Mar 10, 2013, 04:24 AM

70. Lol. n/t

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Response to ChairmanAgnostic (Reply #1)

Sat Mar 9, 2013, 02:42 PM

53. made me giggle

your post. must be something I can look forward to...never getting that dreaded disease.

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Response to G_j (Original post)

Fri Mar 8, 2013, 04:08 PM

3. K&R. There's a scientist (biochemist IIRC) in Colorado Springs that has been working on this

 

principle for years. Every animal on earth is built to accept/utilize cannabinoids, we all evolved that way. The medicinal potential of Marijuana is literally awesome, but of course, because it is a natural plant and cannot be patented, the pharmaceutical industry has blocked research at every opportunity.

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Response to Egalitarian Thug (Reply #3)

Fri Mar 8, 2013, 04:51 PM

10. If he ever needs help, I have plenty of friends who

Could chronicle their experiences.

And you' re right about how Big Pharma is opposed to making the plant legal.

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Response to Egalitarian Thug (Reply #3)

Sat Mar 9, 2013, 03:48 PM

60. Robert Melamede n/t

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Response to RainDog (Reply #60)

Sat Mar 9, 2013, 04:11 PM

62. That's the guy, thank you. n/t

 

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Response to G_j (Original post)

Fri Mar 8, 2013, 04:09 PM

4. fuck! now it is never going to be legal.

 

No way is Big Pharma going to let herb get in the way of the boomer Alzheimer cash cow. We are doomed!

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Response to Warren Stupidity (Reply #4)

Fri Mar 8, 2013, 04:18 PM

6. They'll put it in pills

and sell it for big bucks.

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Response to BainsBane (Reply #6)

Sat Mar 9, 2013, 10:15 AM

34. you can count on that. nt

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Response to BainsBane (Reply #6)

Sat Mar 9, 2013, 12:25 PM

41. They already have a pill but they don't work, that's why you don't hear much about it.

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Response to BainsBane (Reply #6)

Sat Mar 9, 2013, 04:13 PM

63. And it doesn't work very well, but does cost a lot. Corporatocracy. n/t

 

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Response to Warren Stupidity (Reply #4)

Fri Mar 8, 2013, 05:49 PM

15. It was never going to be legal as a grown weed

It will probably be legal at some point as an inhaler produced by RJR or Brown & Williamson with God-knows-what-else added to it.

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Response to Recursion (Reply #15)

Fri Mar 8, 2013, 06:38 PM

27. It is legal as a grown weed in Colorado right now, and...

 

look for more states to come on board, if not this year in legislatures, then in 2014 and 2016 through the initiative process.

It may never be a medicine as a grown weed, but that's a different story.

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Response to Recursion (Reply #15)

Sat Mar 9, 2013, 02:57 PM

55. Seattle

Screamin' in here. Legal as the day is long, our local constabulary thankful to not bust stoners, and the world a friendlier place (and trust me, my uptight neighbors need it). Come on up sometime and enjoy the fog

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Response to G_j (Original post)

Fri Mar 8, 2013, 04:11 PM

5. Marijuana

forget about Alzheimers!

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Response to mitchtv (Reply #5)

Fri Mar 8, 2013, 07:10 PM

32. !

 

--imm

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Response to G_j (Original post)

Fri Mar 8, 2013, 04:25 PM

7. awesome news!!

The spice turmeric also inhibits amyloid beta.

to natural substances that work!

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Response to BuddhaGirl (Reply #7)

Fri Mar 8, 2013, 05:36 PM

13. Great!

 

I can't stand marijuana.

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Response to G_j (Original post)

Fri Mar 8, 2013, 04:26 PM

8. Lose your short term memory now so you don't lose it later!

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Response to cthulu2016 (Reply #8)

Fri Mar 8, 2013, 04:56 PM

12. You forgot your sarcasm tag.

Otherwise that's pure reefer madness.

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Response to tridim (Reply #12)

Sat Mar 9, 2013, 11:46 AM

37. As someone who smoked pot on a prodigious level many years ago it most certainly is not.

 

Last edited Sat Mar 9, 2013, 02:10 PM - Edit history (1)

It's sad how far into denial some pot smokers are. The Science isn't behind you.

How marijuana makes you forget

The drug impairs users’ working memory — the ability to retain and use information over short periods of time. Neuroscientists Giovanni Marsicano of the University of Bordeaux, France, and Xia Zhang of the University of Ottawa Institute of Mental Health Research now show that this common side effect occurs because of a previously unknown signalling mechanism between neurons and non-neuronal cells called astrocytes. Their work is published today in Cell1.

The star-shaped astrocytes have long been considered nothing more than support cells that protect neurons. “Our study provides compelling evidence that astrocytes control neurons and memory,” says Zhang. “The supporting actor has become the leading actor.”

The psychoactive ingredient of marijuana is tetrahydrocannabinol (THC). Using microelectrodes implanted into the brains of anaesthetized rats, the researchers found that the compound weakens the connections, or synapses, between neurons in the hippocampus, a structure that is crucial for memory formation.

They repeated these experiments in two types of mice that had been genetically modified to alter their production of CB1 receptors, the molecules that interact with THC in the brain. One mouse strain lacked CB1 receptors in hippocampal neurons that synthesize the neurotransmitter glutamate; the other lacked them in those that synthesize the neurotransmitter GABA.

http://www.nature.com/news/how-marijuana-makes-you-forget-1.10152#/ref-link-1

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Response to KittyWampus (Reply #37)

Sat Mar 9, 2013, 02:30 PM

52. I know several medical marijuana patients who would strongly disagree with you

It does not matter how much reefer madness people put out there. It does not matter what prohibitive laws they pass. It does not matter how many people they put in jail. Patients will never stop using their medicine. They know it works for them because they see and feel a decrease in their symptoms when they use it, and they will never give it up.

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Response to liberal_at_heart (Reply #52)

Sat Mar 9, 2013, 04:40 PM

64. WTF does that have to do with the FACT MJ effects short term memory. Cause that's all I addressed.

 

the poster I responded to wrongly asserts that saying mj effects our short term memory is reefer madness bullshit.

It's not bullshit.

It's medical fact.

And as someone who smoked quite a lot back in the day… I can't imagine why anyone would deny it.

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Response to KittyWampus (Reply #64)

Mon Mar 11, 2013, 09:35 AM

71. You're putting anecdotal evidence on the same footing with A LOT of statistical

evidence that cannabis doesn't cause neuropsychological/cognitive changes even after long-term use. On an anecdotal level, it's entirely possible that one or more other causes underlie memory problems. It's also possible that heavy long-term cannabis use might affect certain brain conditions negatively -- there aren't any that I know of, but I only stay abreast of the research very casually these days. (Gotta run....there have been some good posts on this thread backing up my statements.)

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Response to KittyWampus (Reply #37)

Sat Mar 9, 2013, 04:06 PM

61. One of the values of mj for PTSD

One of the values of mj for PTSD is the weakening of the connections between emotional response and memory.

The temporary issue of occasional difficulty with memory loss during the time when someone is high, however, is not a permanent feature of cannabis use, as other studies have also demonstrated.

Even in the case of heavy, long term use:

The researchers found only a "very small" impairment in memory and learning among long-term marijuana users. Otherwise, scores on thinking tests were similar to those who don't smoke marijuana, according to a new analysis of 15 previous studies.

In those studies, some 700 regular marijuana users were compared with 484 non-users on various aspects of brain function -- including reaction time, language and motor skills, reasoning ability, memory, and the ability to learn new information.

The marijuana users in those 15 studies -- which lasted between three months to more than 13 years -- had smoked marijuana several times a week or month or daily. Still, researchers say impairments were less than what is typically found from using alcohol or other drugs.

"I just re-published a paper of the first survey for marijuana toxicity done in 1863 by the British government in India that was the most exhaustive medical study of its time in regards to possible difficulties and toxicity of cannabis. And it reached the same conclusion as Grant," Mikuriya tells WebMD. (Tod Mikuriya, MD, former director of non-classified marijuana research for the National Institute of Mental Health Center for Narcotics and Drug Abuse Studies and author of The Marijuana Medical Handbook: A Guide to Therapeutic Use is considered one of the experts in the field of cannabis research/medicine.) "This is merely confirming what was known over 100 years ago, as well as what was learned by various government findings doing similar research -- marijuana is not toxic, but it is a highly effective medicine."


http://www.webmd.com/mental-health/news/20030701/heavy-marijuana-use-doesnt-damage-brain

It's sort of out of proportion to blame people who support legalization for the lies the govt has told about marijuana for more than 70 years, including the FALSE claim made by Ronnie Raygun that marijuana killed brain cells. After years of putting off releasing the scientific study from which this claim was made... )and WHO CHOOSES TO HIDE SCIENTIFIC RESEARCH unless they're merely spouting bullshit propaganda?) Anyway, that study actually found that suffocating animals with carbon dioxide causes cell damage. But not marijuana.

There are far, far more studies that show the benefits of marijuana - real scientific experiments without a political agenda - than there are those showing a reason to continue prohibition. And, frankly, the drugs that pharmaceutical companies make have far worse side effects - so why don't you go off on them for marketing substances that kill, destroy organ function, destroy mental capacity, create permanent damage - you know - maybe some realism is required to not have your hair on fire when someone says something positive about the use of marijuana.

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Response to KittyWampus (Reply #37)

Sat Mar 9, 2013, 10:34 PM

66. Here's the meta analysis that showed NO impairment after 25 days of abstinence.

http://www.ncbi.nlm.nih.gov/pubmed/22731735

Cannabis is the most widely used illicit drug in the U.S., and the number of illicit and licit users is rising. Lasting neurocognitive changes or deficits as a result of use are frequently noted despite a lack of clarity in the scientific literature. In an effort to resolve inconsistencies in the evidence of lasting residual effects of cannabis use, we conducted two meta-analyses. First, we updated a previous meta-analysis on broad nonacute cognitive effects of cannabis use through inclusion of newer studies. In a second meta-analysis, we focused on evidence for lasting residual effects by including only studies that tested users after at least 25 days of abstinence.

In the first meta-analysis, 33 studies met inclusion criteria. Results indicated a small negative effect for global neurocognitive performance as well for most cognitive domains assessed. Unfortunately, methodological limitations of these studies prevented the exclusion of withdrawal symptoms as an explanation for observed effects.

In the second meta-analysis, 13 of the original 33 studies met inclusion criteria. Results indicated no significant effect of cannabis use on global neurocognitive performance or any effect on the eight assessed domains. Overall, these meta-analyses demonstrate that any negative residual effects on neurocognitive performance attributable to either cannabis residue or withdrawal symptoms are limited to the first 25 days of abstinence. Furthermore, there was no evidence for enduring negative effects of cannabis use.


Seems like the science isn't behind you. It's ahead of you.

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Response to cthulu2016 (Reply #8)

Mon Mar 11, 2013, 09:39 AM

72. I had to go back and remind myself what the thread was about. n/t

 

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Response to G_j (Original post)

Fri Mar 8, 2013, 04:40 PM

9. Kicked and recommended.

Thanks for the thread, G_j.

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Response to G_j (Original post)

Fri Mar 8, 2013, 04:54 PM

11. Side effects may include arrest, fines, loss of freedom and possible jail time.

Legalize it NOW. Geez Lou-freaking-ise.

Alzheimer's runs in my family and I will use natural medications as a preventative measure if I want to. Fuck you DEA, it's none of your business.

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Response to G_j (Original post)

Fri Mar 8, 2013, 05:37 PM

14. the title scared me

i was afraid it was going to say that alzheimer's is on the upswing because everyone's getting high!

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Response to barbtries (Reply #14)

Fri Mar 8, 2013, 06:04 PM

16. Same here- I had to skip to the conclusion for clarity.

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Response to barbtries (Reply #14)

Fri Mar 8, 2013, 11:57 PM

33. Don't worry, those "studies" come out regularly

like clockwork

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Response to G_j (Original post)

Fri Mar 8, 2013, 06:23 PM

17. A gram a day to keep the...

...bloody insurance scam driven corporate managed care system away.

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Response to G_j (Original post)

Fri Mar 8, 2013, 06:23 PM

18. Smoking cigarettes also inhibits Alzheimer’s

Researchers have long noted that smokers have a lower rate of AD (although smoking is definitely not a good thing overall).

http://www.sciencedirect.com/science/article/pii/S0006899398001383

http://www.prohealth.com/library/showarticle.cfm?libid=2596

Michael Mullan, the scientist who first discovered the role of beta amyloid plaques in AD has discovered a compound in the tobacco leaf called anatabine that accounts for the diminution of inflammation in the Alzheimer brain. The compound if available to the public OTC.

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Response to aint_no_life_nowhere (Reply #18)

Sat Mar 9, 2013, 03:12 PM

57. Cigarettes also shorten life

and many users never get old enough to get Alzheimer's.

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Response to The Wizard (Reply #57)

Sat Mar 9, 2013, 03:19 PM

58. Absolutely - that's why my post stated "although smoking is definitely not a good thing overall"

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Response to G_j (Original post)

Fri Mar 8, 2013, 06:26 PM

19. I would think this would be easy to test.


Survey the general population, find out if there's an inverse correlation between marijuana use and development of dementia in old age.

If there is, they're onto something. Problem is, I'm not certain the stoner generation has reached old age yet. It may take a while.

Second problem, it's not certain the ameloids cause Alzheimers. They may be just a by-product of the disease progression, though if that's the case, they definitely aggravate it.

Remember, computer modelling tells you only what should happen, not what actually happens.

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Response to caseymoz (Reply #19)

Fri Mar 8, 2013, 06:35 PM

26. It depends on your definition of "old age,"

and I would wager that even "old" stoners (such as myself at 66) don't feel old. I sure as hell don't. My husband, who is a year younger than me, doesn't smoke, and he's always complaining about feeling old.

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Response to Blue_In_AK (Reply #26)

Fri Mar 8, 2013, 07:02 PM

29. Glad to feel like that, but . . .


. . . that's why scientists choose objective standards, like how many years have you been alive, as criteria for their test and control groups. If you feel great at 66 you belong in the study, because statistically a certain number of people that age are going to feel the same way.

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Response to G_j (Original post)

Fri Mar 8, 2013, 06:26 PM

20. light up, everybody!!!

fire 'em up!

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Response to G_j (Original post)

Fri Mar 8, 2013, 06:30 PM

21. inflammation

It sounds like it just helps with inflammation. It's good news but I thought a lot of people already knew this about MJ. I think Alzheimers results from bio-film and the inflammation that it causes .

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Response to G_j (Original post)

Fri Mar 8, 2013, 06:32 PM

23. The smoking lamp is lit.

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Response to G_j (Original post)

Fri Mar 8, 2013, 06:34 PM

24. This is interesting, thanks for posting



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Response to G_j (Original post)

Fri Mar 8, 2013, 06:35 PM

25. After years of painstaking independent research I can report only one worrisome side effect...

Occasional weight gain due to excessive late night snacking. These effects, like so many other problems, are easily countered with a regime of regular aerobic exercise. In my case, bicycling a few times a week in the mountains near my home does the job.

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Response to G_j (Original post)

Fri Mar 8, 2013, 06:43 PM

28. This is why the Feds took out a patent on the use of cannabinoids

 

#6630507

Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases. The cannabinoids are found to have particular application as neuroprotectants, for example in limiting neurological damage following ischemic insults, such as stroke and trauma, or in the treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and HIV dementia

See. if everyone knew the feds had patents*(thanks to an alert DU'er there are many-haven't had time to read up) on the use of the main ingredient in Cannabis how many convictions would juries return for someone growing a plant?

but most people just can't seem to put it together.

Federal Medical Marijuana Prisoners and Cases
http://www.canorml.org/costs/federal_medical_marijuana_prisoners_and_cases

The war on the most useful plant on the planet could be over tomorrow- if the people could just do a little research.

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Response to green for victory (Reply #28)

Sat Mar 9, 2013, 12:39 PM

43. I my case study of 1 I found that it helps my small fiber sensory neuropathy which is,

in my case, my immune system attacks the peripheral nerves causing them to short circuit and send false signals that my feet are on fire, being electrocuted suddenly and w/o warning, ants crawling and biting... It is one of the most painful, chronic conditions. Pot operates to put me in a dissociative state where I can compartmentalize the pain, forgetting it for awhile altogether. None of the powerful pain meds I am prescribed EVER stop me from feeling pain altogether. I would compare the side effects and pot wins hands down there too! Lastly, it's cheaper than the pills by a long shot. Just wish insurance would pay for it anyway, that would be cool to make an insurance company have to pay for my weed!

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Response to G_j (Original post)

Fri Mar 8, 2013, 07:03 PM

30. Wow, this is from the NIH. Seems they don't always agree with FDA on too much.

You ought to go read their abstracts and studies. [Desperately hoping the pugs don't go after their funding and stays off their radar.]
I've spent a lot of time at NIA.NIH.gov lots of good resources though NIA (National Institute on Aging) is a bit childish, like they think seniors want primary colors splashed all over the place

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Response to G_j (Original post)

Fri Mar 8, 2013, 07:06 PM

31. It makes intuitive sense.

When you get stoned, memory decreases, but it comes back as it wears off. So it must kick in some part of the brain responsible for recovering memory.

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Response to G_j (Original post)

Sat Mar 9, 2013, 11:31 AM

35. So we can all be legally stoned in our old age.

Nursing homes will give it out along with daily medicine. Bet you'd see a rise in the number of nursing home patients.

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Response to G_j (Original post)

Sat Mar 9, 2013, 11:37 AM

36. Side effects may include happiness and peace.

Well Hell!

We can't have that. Of course big pharma will turn a simple fix into an expensive pill without those pesky side effects!

What could go wrong?

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Response to G_j (Original post)

Sat Mar 9, 2013, 12:02 PM

40. Awesome! I smoked so much herb from the time that I was 18 until I was 33 that I should

easily have enough residual THC in my system to make me immune from Alzheimer's for the rest of my life.

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Response to G_j (Original post)

Sat Mar 9, 2013, 12:33 PM

42. The US Government owns the patent on cannabinoids as treatment for Alzheimer's and other illnesses.

 

The Significance of US Govt Cannabinoid Patent 6,630,507

http://stopthedrugwar.org/speakeasy/2008/jul/23/significance_us_govt_cannabinoid

2008

When I was at the Patients Out of Time Medical Cannabis conference in Asilomar this last April, I overheard a remark that startled me: "The US Government has a patent on cannabis." I couldn't locate the person who made the comment, so I went home and did some online research. Sure enough, patent number 6,630,507 states unequivocally that cannabinoids are useful in the prevention and treatment of a wide variety of diseases including auto-immune disorders, stroke, trauma, Parkinson's, Alzeheimer's and HIV dementia. The patent, awarded in 2003, is based on research done by the National Institute of Health, and is assigned to the US Dept. of Health and Human Services.

So, why is this important? Here is a legal document, in the public domain, which flies in the face of the US Government's stated position with regard to the classification of cannabis as a Schedule I substance having no "currently accepted medical use". Believe me, citing this patent stops the "medical marijuana is a myth" advocates dead in their tracks. They simply cannot argue with it. The forces that would keep cannabis illegal are vocal and well funded, but they are not impervious to persistent effort. The lynch pin in the War on Drugs is cannabis. Without the suppression and interdiction of this popular and widely used substance, there simply would not be enough "illegal drug use" going on to justify the huge amount of money and resources spent on "fighting drugs."

I believe disseminating information about this patent as widely as possible, and to as many people as possible is a crucial strategy in loosening that lynch pin, and changing public perception about cannabis. I, personally, downloaded the first page of this patent and sent a copy (with the assignee highlighted) to every one of my elected representatives. I have also included information about it in "letters to the editor" referencing any cannabis related news story I come across, I use it as an argument in every State medical cannabis and decriminalization initiative, and have mentioned it in all my comments to online posts and blogs of the same nature. I would be delighted if everyone who believes the War on Drugs is a failed and destructive policy, would do the same, until the existence of this irrefutable patent becomes widely held public knowledge, and government 's rhetoric is shown to be as hollow as a busted drum.

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Response to Fire Walk With Me (Reply #42)

Sat Mar 9, 2013, 12:58 PM

44. wow!

I had no idea, but it figures..,

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Response to Fire Walk With Me (Reply #42)

Sat Mar 9, 2013, 05:08 PM

65. It's a glorius day on DU!

 

Someone else understands the patent!

THE Key to the end of the war. Now if only a reporter could ask about it...

This Oakland Attorney gets it:

Oakland cites surprise medical pot backer

In papers filed late Tuesday with the magistrate who is considering the fate of the Harborside Health Center, lawyers for Oakland said patent and research records reveal that "the government believes in the medical efficacy of cannabis" - contrary to the Justice Department's insistence that marijuana is a dangerous drug with no legitimate use.

Cedric Chao, a lawyer for the city, cited a 2003 patent application by the U.S. government that said cannabis compounds are "useful in the treatment and prophylaxis (prevention) of a wide variety of oxidation-associated diseases," including certain types of strokes and immune-system disorders. Chao quoted another patent application, by two government scientists in 2009, that referred to the "healing properties of Cannabis sativa," or marijuana, that have been "known throughout documented history."

"How can the government credibly deny the benefits of medical cannabis when the government itself is funding cutting-edge research proving the medical benefits of cannabis and seeking patents based on such research?" Chao wrote.

U.S. Attorney Melinda Haag filed suit in July seeking the closure of Harborside and the forfeiture of its offices at 1840 Embarcadero. She said the dispensary, which supplies marijuana to 108,000 patients, is violating federal drug laws.
http://www.sfgate.com/default/article/Oakland-cites-surprise-medical-pot-backer-4113767.php

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Response to green for victory (Reply #65)

Sun Mar 10, 2013, 01:01 AM

68. ...

 



But then it comes down "the US government as monopoly" regarding the eventual application of cannabinoids for medical use. The road to victory is a long one but worth it!

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Response to G_j (Original post)

Sat Mar 9, 2013, 01:51 PM

46. I think I feel the onset of Alzheimer's...

 

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Response to G_j (Original post)

Sat Mar 9, 2013, 02:21 PM

48. HUGE K & R !!!

 


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Response to G_j (Original post)

Sat Mar 9, 2013, 02:23 PM

49. I suspect that Monsterano already has its patented round up ready pot seeds ...ready for market.

 

Just wait till the pot growers get hauled off to court by Monsterano for cross pollinated seeds.

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Response to G_j (Original post)

Sat Mar 9, 2013, 02:28 PM

50. in my own intensive studies of pot

 

I have become somewhat anti materialistic so this may be why some people want pot to remain "the evil weed".

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Response to G_j (Original post)

Sat Mar 9, 2013, 02:43 PM

54. THC as antagonist for Alzheimers mechanism



this is very interesting work

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Response to G_j (Original post)

Sat Mar 9, 2013, 03:06 PM

56. Many of our laws are rooted

in superstition and false belief. It's time for America to set aside ignorance and accept science.

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Response to G_j (Original post)

Sat Mar 9, 2013, 03:45 PM

59. REMOVE CANNABIS FROM SCHEDULE I

or, rather, remove it from the drug schedule entirely and let the pharmaceutical knock offs remain.

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Response to RainDog (Reply #59)

Sat Mar 9, 2013, 10:47 PM

67. b-b-but Marijuana doesn't have legitimate medical uses!

The DEA told me that, so it must be true!

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Response to backscatter712 (Reply #67)

Sun Mar 10, 2013, 02:53 AM

69. Former head of the DEA called for nullification of the WA and CO laws

honestly, you're not someone who gives a shit about the law when you think you should have the right to overturn laws voted by majorities concerning an issue about which the federal govt. has been a shameful example of EVERYTHING WRONG with government use and abuse of power.

They're like religious extremists who don't care if all the evidence indicates that evolution is reality, not a 6000 year-old earth - they want to believe something and no overwhelming evidence to the contrary will make them change their minds.

....sort of like the inquisition.

It's gotten to the point that it's ridiculous. The internet made it possible for people to read studies for themselves. But those folks still believe their own propaganda - or else they care more about their own pockets than they do democracy or the scientific method.

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Response to G_j (Original post)

Mon Mar 11, 2013, 11:42 AM

73. I have a history of Alzheimer's in my family...

I honestly wish pot or at least THC was legalized.

I've never smoked anything in my life let alone pot and frankly, my choice, I probably still won't even with this research, however, I would be more apt to taking the THC in a pill or liquid form.

As I am officially past the middle age hurdle, I worry more and more each day about my mind slipping away and leaving my GF in a really bad situation. Yes, we have taken long term measures both financial and personally, but it still worries me.

I try to challenge my mind each and every day, I have taken up the guitar and am training myself in java. I do crossword puzzles and the jumble, etc all things that are supposed to help at least delay or supposedly blunt it's effects.

It's like living with a sword of Damocles over my head.

Added to that, both breast and colon cancer run in my family.

Yayyyy. Sorry for the pity party. Cheers!

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