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Related: Editorials & Other Articles, Issue Forums, Alliance Forums, Region ForumsOxadiazoles: New Class Of Antibiotics Discovered
http://www.science20.com/news_articles/oxadiazoles_new_class_antibiotics_discovered-131265The new class of antibiotics, called oxadiazoles, was discovered in silico and has shown promise in the treatment of MRSA in mouse models of infection. The researchers who screened 1.2 million compounds found that the oxadiazole inhibits a penicillin-binding protein, PBP2a, and the biosynthesis of the cell wall that enables MRSA to resist other drugs
The oxadiazoles are also effective when taken orally. This is an important feature as there is only one marketed antibiotic for MRSA that can be taken orally.
MRSA has become a global public-health problem since the 1960s because of its resistance to antibiotics. In the United States alone, 278,000 people are hospitalized and 19,000 die each year from infections caused by MRSA. Only three drugs currently are effective treatments, and resistance to each of those drugs already exists.
Article: "Discovery of a New Class of Non-beta-lactam Inhibitors of Penicillin-Binding Proteins with Gram-Positive Antibacterial Activity" is
published in the Journal of the American Chemical Society.
http://www.ncbi.nlm.nih.gov/pubmed/24517363
Sid
FSogol
(45,476 posts)lostincalifornia
(3,639 posts)COLGATE4
(14,732 posts)that when this finally comes to market it won't become useless by virtue of being overprescribed.
Aristus
(66,316 posts)I still have patients come in every once in a while asking: "I just have a little cold. Could you give me some antibiotics?"
NO! NO! A thousand times, NO!
Antibiotics are for bacterial infections, not for viral infections, which is what a cold is.
tridim
(45,358 posts)Aristus
(66,316 posts)Providers who give in and prescribe antibiotics for a patient with a virus have probably just gotten tired of having to explain to the patient about the dangers of overprescribing antimicrobials.
That, and having to listen to an indignant patient say: "I know my body!" for the umpteenth time...
Viva_La_Revolution
(28,791 posts)*only funny when you say it out loud
FreedRadical
(518 posts)MineralMan
(146,286 posts)even more good results. We need these antibiotics.
FourScore
(9,704 posts)Avalux
(35,015 posts)so probably not effective at all. It's great news though - we really need NEW antibiotics to combat the increasing threat of antibiotic resistant bacteria.
progressoid
(49,978 posts)phantom power
(25,966 posts)phantom power
(25,966 posts)SidDithers
(44,228 posts)The initial screening of 1.2 million compounds pointed them in the direction to do further research.
Cool stuff.
Sid
librechik
(30,674 posts)I dread getting pneumonia--in a hospital.
Bernardo de La Paz
(48,994 posts)On edit: Answered my own question.
It turns out to mean "by computer simulation".
It is initially confusing because glass is basically silicon dioxide.
arendt
(5,078 posts)BTW this year's Nobel prize in chemistry was given for computational chemistry.
The computer revolution and a library of over 100,000 X-ray structures of protein molecules at angstrom resolution have made it possible to approximately calculate how a drug molecule will bind to a protein. You can "dock" upwards of a million compounds a day via "virtual screening".
DemocratsUnite
(2 posts)To all of those righties who demean science, keep your ignorant hands off of these antibiotics, you don't deserve them.
Avalux
(35,015 posts)And even if they're a complete asshole.
arendt
(5,078 posts)Just FYI, an oxidiazole is chemical shorthand. The molecule is MORE than just an oxidiazole (5 membered ring with 3 carbons and two nitrogens, plus an oxygen hanging off it). Here's a
" target="_blank"> picture of the molecule from the technical article.
Chemists often describe a class or series of molecules by a prominent "functional group". This group might be the starting point of a synthesis, or just the backbone of the molecule.
</medicinal chemistry>
arendt
(5,078 posts)arendt
(5,078 posts)arendt
(5,078 posts)From the right hand picture, it looks like the oxygen is hiding underneath.
arendt
(5,078 posts)oxa = oxygen
di = two
az = nitrogen (azide)
ole = five membered ring
SidDithers
(44,228 posts)It's all geek to me. I'm a physics guy, not a chemistry guy.
Sid
Shanti Mama
(1,288 posts)How will all the American-exceptionalist idiots justify using a drug discovered by "unAmericans"?
dembotoz
(16,799 posts)freshwest
(53,661 posts)SidDithers
(44,228 posts)Sid
MattBaggins
(7,904 posts)just big Pharma killing more people for money.