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The 'chemputer' that could print out any drug
http://www.guardian.co.uk/science/2012/jul/21/chemputer-that-prints-out-drugsHe shows me the printer, a nondescript version of the £1,200 3D printer used in the Fab@Home project, which aims to bring self-fabrication to the masses. After a bit of trial and error, Cronin's team discovered that it could use a bathroom sealant as a material to print reaction chambers of precisely specified dimensions, connected with tubes of different lengths and diameters. After the bespoke miniature lab had set hard, the printer could then inject the system reactants, or "chemical inks", to create sequenced reactions.
The "inks" would be simple reagents, from which more complex molecules are formed. "If I was being facetious I would say that to find your inks you would go to the periodic table: carbon, hydrogen, oxygen, and so on," Cronin says, "but obviously you can't handle all those substances very well, so it would have to be a bit more complex than that. If you were looking to make a sugar, for example, you would start with your set of base sugars and mix them together. When we make complex molecules in the traditional way with test tubes and flasks, we start with a smaller number of simpler molecules." As he points out, nearly all drugs are made of carbon, hydrogen and oxygen, as well as readily available agents such as vegetable oils and paraffin. "With a printer it should be possible that with a relatively small number of inks you can make any organic molecule," he says.
The real beauty of Cronin's prototype system, however, is that it allows the printer not only to control the sequences and exact calibration of inks, but also to shape, from a tested blueprint, the environment in which those reactions take place. The scale and architecture of the miniature printed "lab" could be pre-programmed into software and downloaded for use with a standard set of inks. In this way, not only the combinations of reactants but also the ratios and speed at which they combine could be ingrained into the system, simply by changing the size of reaction chambers and their relation with one another; Cronin calls this "reactionware" or, because it depends on a conceptualised sequence of flow and reorientation in a 3D space, "Rubik's Cube chemistry".
The "inks" would be simple reagents, from which more complex molecules are formed. "If I was being facetious I would say that to find your inks you would go to the periodic table: carbon, hydrogen, oxygen, and so on," Cronin says, "but obviously you can't handle all those substances very well, so it would have to be a bit more complex than that. If you were looking to make a sugar, for example, you would start with your set of base sugars and mix them together. When we make complex molecules in the traditional way with test tubes and flasks, we start with a smaller number of simpler molecules." As he points out, nearly all drugs are made of carbon, hydrogen and oxygen, as well as readily available agents such as vegetable oils and paraffin. "With a printer it should be possible that with a relatively small number of inks you can make any organic molecule," he says.
The real beauty of Cronin's prototype system, however, is that it allows the printer not only to control the sequences and exact calibration of inks, but also to shape, from a tested blueprint, the environment in which those reactions take place. The scale and architecture of the miniature printed "lab" could be pre-programmed into software and downloaded for use with a standard set of inks. In this way, not only the combinations of reactants but also the ratios and speed at which they combine could be ingrained into the system, simply by changing the size of reaction chambers and their relation with one another; Cronin calls this "reactionware" or, because it depends on a conceptualised sequence of flow and reorientation in a 3D space, "Rubik's Cube chemistry".
REAL interesting stuff!
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