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Fri Apr 24, 2020, 11:19 AM

Researchers cut chloroquine study short over safety concerns, citing a 'primary outcome' of death

Source: CNBC

Citing a “primary outcome” of death, researchers cut short a study testing anti-malaria drug chloroquine as a potential treatment for Covid-19 after some patients developed irregular heart rates and nearly two dozen of them died after taking doses of the drug daily.

Scientists say the findings, published Friday in the peer-reviewed Journal of the American Medical Association, should prompt some degree of skepticism from the public toward enthusiastic claims about and perhaps “serve to curb the exuberant use” of the drug, which has been touted by President Donald Trump as a potential “game-changer” in the fight against the coronavirus.

Chloroquine gained widespread international attention following two small studies, including one with 36 Covid-19 patients published March 17 in France, found that most patients taking the drug cleared the coronavirus from their system a lot faster than the control group. The JAMA report said those trials didn’t meet the publishing society’s standards.

“These weak findings, bolstered by anecdotal reports and media attention, have fostered widespread belief in the efficacy of these agents,” according to a separate warning about prescribing the drugs issued Friday alongside the new JAMA study.

Read more: https://www.cnbc.com/2020/04/24/coronavirus-citing-a-primary-outcome-of-death-researchers-cut-chloroquine-study-short-over-safety-concerns.html

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Reply Researchers cut chloroquine study short over safety concerns, citing a 'primary outcome' of death (Original post)
SouthernCal_Dem Apr 2020 OP
The Velveteen Ocelot Apr 2020 #1
Greg K Apr 2020 #4
SouthernCal_Dem Apr 2020 #2
NoMoreRepugs Apr 2020 #3
Wellstone ruled Apr 2020 #5
IronLionZion Apr 2020 #6
turbinetree Apr 2020 #7
NNadir Apr 2020 #8
Pluvious Apr 2020 #9

Response to SouthernCal_Dem (Original post)

Fri Apr 24, 2020, 11:21 AM

1. If death is the "primary outcome," I guess it's time to give up.

Everything Trump touches, or even talks about, dies.

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Response to The Velveteen Ocelot (Reply #1)

Fri Apr 24, 2020, 11:36 AM

4. "What do you have to lose?" he said.

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Response to SouthernCal_Dem (Original post)

Fri Apr 24, 2020, 11:21 AM

2. Here's a video of Trump pushing the drug which primarily causes DEATH in coronavirus patients!

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Response to SouthernCal_Dem (Original post)

Fri Apr 24, 2020, 11:24 AM

3. Ingraham needs to have her feet held to the fire for

her support for this quack remedy/cure spouted by tRUMP - May get be more accurate to call it her helping to solidify the idea into his tiny brainpan.

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Response to SouthernCal_Dem (Original post)

Fri Apr 24, 2020, 11:39 AM

5. Waiting for the TV Ads

 

soliciting Harmed Persons for a Class Action Suit against the Orange Anus and his crew. You just know it is coming.

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Response to SouthernCal_Dem (Original post)

Fri Apr 24, 2020, 11:40 AM

6. That's the standard GOP desired outcome

for most of their policies

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Response to SouthernCal_Dem (Original post)

Fri Apr 24, 2020, 11:57 AM

7. And so "all" of the right wing assholes that were promoting this "drug" while on TV

not being anywhere near a doctor should be charged with murder and practicing without a license................and then have that orange blob playing doctor and practicing without a license should be IMPEACHED............again for playing doctor.............

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Response to SouthernCal_Dem (Original post)

Fri Apr 24, 2020, 12:18 PM

8. The exact language of the findings from the open sourced JAMA is...

...

Findings In this phase IIb randomized clinical trial of 81 patients with COVID-19, an unplanned interim analysis recommended by an independent data safety and monitoring board found that a higher dosage of chloroquine diphosphate for 10 days was associated with more toxic effects and lethality, particularly affecting QTc interval prolongation. The limited sample size did not allow the study to show any benefit overall regarding treatment efficacy.


The full paper, open sourced, is here:

Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection A Randomized Clinical Trial (Mayla Gabriela Silva Borba, MD1,2; Fernando Fonseca Almeida Val, PhD1,2; Vanderson Souza Sampaio, PhD1,2,3; et al, JAMA, April 24, 2020.)

This fool, the so called "President of the United States" should be arrested for practicing medicine without a license, and sued for malpractice.

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Response to SouthernCal_Dem (Original post)

Fri Apr 24, 2020, 12:50 PM

9. And the number seven trending hashtag is #TidePodPresident

Truly, we are the Number One Stupid Country on the planet.

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