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Thu Oct 29, 2015, 12:29 AM

“We’ve restored learning and memory 100 per cent, to a level comparable with youth”

Old rat brains rejuvenated and new neurons grown by asthma drug

It’s as good as new. An asthma drug has rejuvenated rat brains, making old rats perform as well as young rats in tests of memory and cognition. The drug also encouraged the birth of new brain cells.

As we get older, most of us will experience some kind of brain degeneration. Typically, we lose the ability to make new neurons. Another problem is chronic, low-grade inflammation in the brain, which is implicated in many age-related brain disorders.

...

A drug called montelukast (Singulair), regularly prescribed for asthma and allergic rhinitis, blocks these receptors, so Aigner and his colleagues tried it on young and old rats. The team used oral doses equivalent to those taken by people with asthma. The older animals were 20 months old – roughly equivalent to between 65 and 75 in human years. The younger rats were 4 months old – about 17 in human years. The animals were fed the drug daily for six weeks, while another set of young and old rats were left untreated. There were 20 young and 14 old rats in total.

...

By the end of their six-week drug regime, though, old animals performed as well as their younger companions. “We’ve restored learning and memory 100 per cent, to a level comparable with youth,” says Aigner. He presented his findings last week at the Society for Neuroscience meeting in Chicago.

When the team studied the brains of the animals, they found that old rats that had been given montelukast had 80 per cent less inflammation. They also had an enhanced level of new neuron growth compared with untreated old rats – about 50 per cent of that seen in young rats, says Aigner.

The team also found that the blood-brain barrier – which stops infectious agents reaching the brain and which weakens in old age – was stronger in treated old rats. “Structurally, the brain had rejuvenated,” says Aigner.
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https://www.newscientist.com/article/dn28384-old-rat-brains-rejuvenated-and-new-neurons-grown-by-asthma-drug/

First, the drug is know to be psychoactive and has suicide as a possible side effect. I thought that was an important warning to include in case anyone is wanting to experiment.

From my own experienceI believe times of intense learning can also trigger a lot of effects that are pretty strange. The dreams, in particular become very vivid and intense. No particular point to that item, t's just something I noticed when I found myself immersed for a prolonged period in a totally different culture.

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Reply “We’ve restored learning and memory 100 per cent, to a level comparable with youth” (Original post)
kristopher Oct 2015 OP
TreasonousBastard Oct 2015 #1
jtuck004 Oct 2015 #10
PoliticAverse Oct 2015 #2
NBachers Oct 2015 #3
Kalidurga Oct 2015 #4
merrily Oct 2015 #5
bemildred Oct 2015 #6
kristopher Oct 2015 #7
Marie Marie Oct 2015 #8
Gloria Oct 2015 #9
Roy Rolling Oct 2015 #11

Response to kristopher (Original post)

Thu Oct 29, 2015, 12:33 AM

1. OK, has anyone noticed asthma patients having rejuvenated brains?

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Response to TreasonousBastard (Reply #1)

Thu Oct 29, 2015, 03:01 AM

10. No. But they often steal cheese and run to a dark closet to eat it. n/t

 

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Response to kristopher (Original post)

Thu Oct 29, 2015, 12:39 AM

2. Oh sure, lets make rats smarter and longer living. n/t

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Response to PoliticAverse (Reply #2)

Thu Oct 29, 2015, 12:43 AM

3. They had a debate tonight.

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Response to NBachers (Reply #3)

Thu Oct 29, 2015, 12:53 AM

4. It would seem the drug doesn't work as advertised then

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Response to kristopher (Original post)

Thu Oct 29, 2015, 01:07 AM

5. That's very promising--unless it runs up the suicide rate.

I hate death as a side effect.

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Response to kristopher (Original post)

Thu Oct 29, 2015, 01:29 AM

6. Being anti-inflammatory, that makes sense.

I wonder if a retrospective study on Singulair users would turn something up.

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Response to bemildred (Reply #6)

Thu Oct 29, 2015, 01:43 AM

7. I have no doubt we'll find out soon. nt

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Response to kristopher (Original post)

Thu Oct 29, 2015, 01:48 AM

8. I was on Singulair for years until I stopped taking it.

Or rather, until my prescription plan wanted me and my Doctor to jump through hoops to justify them paying for it. And all this time I thought it was coming to DU that was making me smarter. Hmmm...

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Response to Marie Marie (Reply #8)

Thu Oct 29, 2015, 02:58 AM

9. I had it to but I saw no difference in my asthma

Worst Pills has it on avoid list, partly because it is not effective as touted...

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Response to kristopher (Original post)

Thu Oct 29, 2015, 03:13 AM

11. Side Effects

It says one of the side effects is that the drug may be psychoactive. Well, duh.

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