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Sun Apr 19, 2020, 10:50 AM

How does coronavirus kill? Clinicians trace a ferocious rampage through the body, from brain to toes

( But hey, lets liberate the country, because this is a no big deal pandemic. )

by Meredith Wadman, Jennifer Couzin-Frankel, Jocelyn Kaiser, Catherine Matacic

Apr. 17, 2020 , 6:45 PM

Science’s COVID-19 reporting is supported by the Pulitzer Center.

On rounds in a 20-bed intensive care unit (ICU) one recent day, physician Joshua Denson assessed two patients with seizures, many with respiratory failure and others whose kidneys were on a dangerous downhill slide. Days earlier, his rounds had been interrupted as his team tried, and failed, to resuscitate a young woman whose heart had stopped. All shared one thing, says Denson, a pulmonary and critical care physician at the Tulane University School of Medicine. “They are all COVID positive.”

As the number of confirmed cases of COVID-19 surges past 2.2 million globally and deaths surpass 150,000, clinicians and pathologists are struggling to understand the damage wrought by the coronavirus as it tears through the body. They are realizing that although the lungs are ground zero, its reach can extend to many organs including the heart and blood vessels, kidneys, gut, and brain.

“[The disease] can attack almost anything in the body with devastating consequences,” says cardiologist Harlan Krumholz of Yale University and Yale-New Haven Hospital, who is leading multiple efforts to gather clinical data on COVID-19. “Its ferocity is breathtaking and humbling.”


Understanding the rampage could help the doctors on the front lines treat the fraction of infected people who become desperately and sometimes mysteriously ill. Does a dangerous, newly observed tendency to blood clotting transform some mild cases into life-threatening emergencies? Is an overzealous immune response behind the worst cases, suggesting treatment with immune-suppressing drugs could help? What explains the startlingly low blood oxygen that some physicians are reporting in patients who nonetheless are not gasping for breath? “Taking a systems approach may be beneficial as we start thinking about therapies,” says Nilam Mangalmurti, a pulmonary intensivist at the Hospital of the University of Pennsylvania (HUP).

https://www.sciencemag.org/news/2020/04/how-does-coronavirus-kill-clinicians-trace-ferocious-rampage-through-body-brain-toes

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Reply How does coronavirus kill? Clinicians trace a ferocious rampage through the body, from brain to toes (Original post)
BeckyDem Apr 2020 OP
empedocles Apr 2020 #1
BeckyDem Apr 2020 #2
agingdem Apr 2020 #4
eppur_se_muova Apr 2020 #3
CrispyQ Apr 2020 #5

Response to BeckyDem (Original post)

Sun Apr 19, 2020, 10:55 AM

1. Great article. Thank you

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Response to empedocles (Reply #1)

Sun Apr 19, 2020, 10:58 AM

2. You're very welcome. It scared the hell out of me.

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Response to empedocles (Reply #1)

Sun Apr 19, 2020, 11:41 AM

4. last October I went into septic shock

the doctor's told my daughter if there were other family members to call then do it now...obviously I lived..reading this article the symptoms are very similar to what I experienced

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Response to BeckyDem (Original post)

Sun Apr 19, 2020, 11:21 AM

3. Yep, just like the flu. nt

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Response to BeckyDem (Original post)

Sun Apr 19, 2020, 12:31 PM

5. Great article, good illustration, too.

What an insidious little fucker this virus is. I read that bats have a crazy good immune system and bio-bugs that come from them are extra virulent.

Thanks for posting.

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