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Latin America
Related: About this forumA gene variant partly explains why Peruvians are among the world's shortest people
A common variation in DNA reduces some people's height by about 2 centimeters, on average
Peruvians, like this man walking in the ancient Incan village of Ollantaytambo, are some of the worlds shortest people as a population. Some carry a version of a gene that partly explains why.
JANNHUIZENGA/ISTOCK UNRELEASED/GETTY IMAGES
By Tina Hesman Saey
5 HOURS AGO
Nearly 4,000 common variations in DNA are known to affect height, with each one nudging stature up or down a millimeter or so. But a gene variant found in almost 5 percent of Peruvians reduces height by 2.2 centimeters, on average.
Thats the biggest effect on stature recorded to date for a common version of a gene. Some rare variations in DNA have much larger effects on height, but they tend to be found in less than 1 percent of people.
People who carry two copies of the gene variant one inherited from each parent are, on average, about 4.4 centimeters shorter than the average height of people who dont carry the variant, researchers report May 13 in Nature. The finding partially explains why the Peruvian people are among the shortest in the world. Men average 165.3 centimeters (about 5 feet, 4 inches) tall and women 152.9 cm (about 5 feet) tall.
The variant is located in the gene known as fibrillin 1, or FBN1, which produces a protein involved in forming bone, connective tissues, skin and other tissues. Some rare FBN1 variations lead to Marfan syndrome, a disorder that leads people to be tall, lanky and prone to heart and blood vessel ruptures and other health problems (SN: 6/25/08).
But those 5 percent of Peruvians who carry [this common variant] are not sick by any pathological definition, says statistical geneticist Samira Asgari of Brigham and Womens Hospital and Harvard Medical School in Boston.
Asgari and colleagues found evidence that natural selection has favored the short-stature variant, although exactly what evolutionary advantage it gives the Peruvians who carry it is not clear.
https://www.sciencenews.org/article/gene-variant-height-peruvians-short
(Short article, no more at link.)
Also posted in Science:
https://www.democraticunderground.com/122869439
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A gene variant partly explains why Peruvians are among the world's shortest people (Original Post)
Judi Lynn
May 2020
OP
2 centimeters is less than one inch...at least nobody who thinks this is important has ever
abqtommy
May 2020
#2
It did occur to me I have never heard one person mention Peruvian people are very short.
Judi Lynn
May 2020
#3
tblue37
(65,319 posts)1. K&R. nt
abqtommy
(14,118 posts)2. 2 centimeters is less than one inch...at least nobody who thinks this is important has ever
told me to inject or drink bleach...
Judi Lynn
(160,516 posts)3. It did occur to me I have never heard one person mention Peruvian people are very short.
It could be only people with a lot of time on their hands are the ones who would, or who would be convinced they are really good at understanding complex subjects like medical science or controlling the world and even outer space.
abqtommy
(14,118 posts)4. I find that judging people by the size of their heart works out better/more accurately for me.
But that's a topic for another day!