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BPA Exposure Affects Heart Health of Males and Females Differently in Mice
http://healthnews.uc.edu/news/?/25627/[font face=Serif]01/16/15
[font size=5]BPA Exposure Affects Heart Health of Males and Females Differently in Mice[/font]
[font size=3]CINCINNATI—Heart function and blood pressure in mice exposed to bisphenol A (BPA) from birth though young adulthood are affected differently in males and females, with females at greater risk of damage from stress, a study from a University of Cincinnati (UC) researcher has found.
...
A research team led by Scott Belcher, PhD, professor of pharmacology and cell biophysics, Robin Gear, principal research assistant, and Eric Kendig, PhD, former UC postdoctoral fellow, found that in young BPA exposed female mice, the heart is more sensitive to stress-induced ischemic damage in a way not observed in untreated female mice.
In BPA-exposed female mice, isoproterenol, a drug that leads to hypertrophy (tissue enlargement) by mimicking some effects of a heart attack, caused increased heart muscle damage along with accumulation of collagen - an indicator of fibrosis or scarring - in the heart, says Belcher, the study’s principal investigator. In male mice BPA alone increased fibrosis, however researchers did not observe an additional increase in fibrosis, ischemic damage, or hypertrophy in response to isoproterenol treatments.
BPA, an environmental pollutant with estrogen-like activity, is used to make polycarbonate plastic and epoxy resins and is a common contaminant of many packaged foods and beverages. Numerous studies have linked BPA to neurological defects, diabetes and breast and prostate cancer.
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http://dx.doi.org/10.1210/en.2014-1847[font size=5]BPA Exposure Affects Heart Health of Males and Females Differently in Mice[/font]
[font size=3]CINCINNATI—Heart function and blood pressure in mice exposed to bisphenol A (BPA) from birth though young adulthood are affected differently in males and females, with females at greater risk of damage from stress, a study from a University of Cincinnati (UC) researcher has found.
...
A research team led by Scott Belcher, PhD, professor of pharmacology and cell biophysics, Robin Gear, principal research assistant, and Eric Kendig, PhD, former UC postdoctoral fellow, found that in young BPA exposed female mice, the heart is more sensitive to stress-induced ischemic damage in a way not observed in untreated female mice.
In BPA-exposed female mice, isoproterenol, a drug that leads to hypertrophy (tissue enlargement) by mimicking some effects of a heart attack, caused increased heart muscle damage along with accumulation of collagen - an indicator of fibrosis or scarring - in the heart, says Belcher, the study’s principal investigator. In male mice BPA alone increased fibrosis, however researchers did not observe an additional increase in fibrosis, ischemic damage, or hypertrophy in response to isoproterenol treatments.
BPA, an environmental pollutant with estrogen-like activity, is used to make polycarbonate plastic and epoxy resins and is a common contaminant of many packaged foods and beverages. Numerous studies have linked BPA to neurological defects, diabetes and breast and prostate cancer.
...[/font][/font]
