HomeLatest ThreadsGreatest ThreadsForums & GroupsMy SubscriptionsMy Posts
DU Home » Latest Threads » Forums & Groups » Topics » Health » Addiction & Recovery (Group) » Anti-anxiety drug found t...

Sun Feb 11, 2018, 07:34 AM

Anti-anxiety drug found to undo some of alcohol's ill effects on the brain

Researchers at the Queensland University of Technology (QUT) have discovered a surprising secondary function for an existing drug. Tandospirone is used in Japan and China to treat anxiety and depression, but now Australian researchers have found that it can "reboot" the brain to reverse some of the negative effects of heavy alcohol consumption.

Tandospirone, or Sediel as it's known commercially, is most commonly prescribed to combat generalized anxiety disorder and depression. It works by selectively acting on the serotonin receptor 5-HT1A in the brain, and according to the Japanese company that produces it, the drug is non-addictive, non-sedative, and virtually free of adverse side effects.

Depression and anxiety often go hand-in-hand with substance abuse, including alcohol. As the QUT researchers say, those negative emotions can spring up during withdrawal, and may lead to a relapse. Tandospirone may be able to interrupt that cycle by quelling depression and anxiety, preventing a recovering alcoholic from caving in to their cravings again.

<snip>

But the discovery that really surprised the team was the fact that tandospirone was also able to reverse some effects that binge drinking can inflict on the process on neuron generation. Normally, the brain replenishes cells in a process called neurogenesis, but long-term heavy drinking can damage that process. The QUT study found that tandospirone can undo the negative impact on neurogenesis caused by excessive alcohol.

"This is not just another drug that shows promise in helping to reduce binge drinking," says Selena Bartlett, lead researcher on the study. "While it could possibly have that effect, it might be able to help reboot the brain and reverse the deficits the alcohol abuse causes both the inhibition to the brain's ability to regenerate, and the behavioural consequences that come from what alcohol is doing to the brain, like increases in anxiety and depression."

https://newatlas.com/tandospirone-anxiety-drug-alcohol-brain-damage/53332/

4 replies, 1210 views

Reply to this thread

Back to top Alert abuse

Always highlight: 10 newest replies | Replies posted after I mark a forum
Replies to this discussion thread
Arrow 4 replies Author Time Post
Reply Anti-anxiety drug found to undo some of alcohol's ill effects on the brain (Original post)
Rhiannon12866 Feb 2018 OP
marble falls Feb 2018 #1
JDC Feb 2018 #2
irisblue Feb 2018 #3
Rhiannon12866 Feb 2018 #4

Response to Rhiannon12866 (Original post)

Sun Feb 11, 2018, 09:15 AM

1. Pretty amazing article, few negative side effects and can reverse brain damage from....

alcohol? Sounds too good to be true. Wait until a US pharmaceutical conglomerate gets a hold of it.

Reply to this post

Back to top Alert abuse Link here Permalink


Response to Rhiannon12866 (Original post)

Sun Feb 11, 2018, 10:08 AM

2. Very interesting

Reply to this post

Back to top Alert abuse Link here Permalink


Response to Rhiannon12866 (Original post)

Sun Feb 11, 2018, 04:11 PM

3. Huh...so decreasing the depression/anxiety combo with this med

Makes the use of alcohol, as a d/a self treatment less likely.

Reply to this post

Back to top Alert abuse Link here Permalink


Response to irisblue (Reply #3)

Sun Feb 11, 2018, 04:19 PM

4. And apparently it can help "heal" the brain, which is huge

It made me think of a new guy who has started attending my beginners' meeting. He apparently had long time sobriety and then relapsed for quite awhile and now he's back - and he seems to have difficulty speaking and reading. It's heartbreaking to see those who suffer permanent damage, it would be a miracle if there was something that could help them and also help prevent relapse.

Reply to this post

Back to top Alert abuse Link here Permalink

Reply to this thread