Interferon decreases HIV-1 levels, controls virus after stopping antiretroviral therapy
A multi-institutional team of researchers, led by The Wistar Institute, has announced the results of a clinical trial that shows how the immune system can engage in fighting HIV infection if given the right boost. In their study, HIV-infected volunteers suspended their daily antiretroviral therapy to receive weekly doses of interferon-alpha, an antiviral chemical produced by the human immune system. The study provides the first clinical evidence for a means of reducing the persistent amount of HIV in patients and the ability to control HIV without continued antiretroviral therapy.
Wistar's Luis J. Montaner, D.V.M., D.Phil., today presents their findings of the first clinical strategy able to harness host control and decrease HIV reservoir measures, at the 2012 Conference on Retroviruses and Opportunistic Infections in Seattle, Washington. HIV reservoirs are populations of cells that harbor HIV-1, enabling the virus to persist as a chronic infection.
"Our data shows that our human immune response can be made to control HIV in persons who have otherwise lost that ability and, if sustained by natural interferon production, it establishes proof-of-concept that a functional cure is theoretically possible," said Montaner, a professor at Wistar and director of the Institute's HIV-1 Immunopathogenesis Laboratory. "And while we still have much to pursue with this early clinical finding, I firmly believe this gives us hope that one day we can control—and eventually eradicate—HIV in absence of antiretroviral therapy."
The trial showed that interferon-alpha when used as a drug (Peg-IFN-?2A) sustained control of HIV in 9 of 20 patients while also decreasing measures of HIV reservoirs in patients otherwise dependent on antiretroviral therapy (ART). No other clinical strategy to date has shown an impact on decreasing integrated HIV DNA levels in HIV-infected humans.
http://www.sciencecodex.com/interferon_decreases_hiv1_levels_controls_virus_after_stopping_antiretroviral_therapy-87448
I will definitely be talking to my Doctor about this.
