"3 Sad Surprises: The Human Genome Project"

[ohgeewhiz]

Published on Jul 24, 2012 by scishow
Hank tells us three surprises about human DNA which we learned because of the Human Genome Project.


Find out more about the Human Genome Project at www.ornl.gov/hgmis and about the National Human Genome Research Institute at http://www.genome.gov

scishow, hank green

[WCGreen]

1. that is very cool..

I just subscribed to the channel. It's good to have some science at your hand....

[ohgeewhiz]

2. If you loved that one, try "Epigenetics"

a link is in the video above, but here it is!

Fascinating stuff.

[rexcat]

4. The histone deacetylase inhibitors (HDAC inhibitors)...

are an interesting group of drugs. Some have been successfully used to bring about remission in lymphomas but at a price. At high doses there can be DNA damage, at least in the rat model. The side-effects are tolerable for the most part as long as the drugs are given at low dose. At high doses all hell can break out as far as adverse events.

The HDAC inhibitors open up the DNA around the histones so that genes can express themselves, such as the anti-tumor gene and in breast cancer the HDAC inhibitors can cause the re-expression of estrogen receptor proteins so other drugs can "attack" the tumors. Those drugs are less toxic than the chemotherapy drugs.

[MisterP]

3. "DNA tells a story"

"there's only one character, and not a very convincing one at that"