Sleep well. Take time out to relax. Connect with your friends and family. Such things would be advisable at any time – but might it be especially important in the coming months. According to a growing body of evidence, our psychological state can shape the immune system’s reaction to a new vaccine – including the development of protective antibodies that will help us to fend off infection.

While the exact mechanisms behind these effects are still under discussion, scientists studying psychoneuroimmunology have found many ways that the mind can influence the body. Stress hormones such as cortisol are known to disrupt overall immune function, so that it fails to respond to threats in the most appropriate way. The poor sleep and depression that arise from chronic stress can also lead to low-grade inflammation throughout the body, which also seems to inhibit the production of antibodies.

We are still waiting for studies that look specifically at the new Sars-CoV-2 shots. But given the variety of the research, on many different types of vaccinations, there is every reason to think these factors will be relevant to the current immunisation programme.

https://www.theguardian.com/society/2021/mar/14/how-your-state-of-mind-could-affect-your-covid-vaccination-psychology-stress-sleep-exercise-anxiety