Using cannabis to treat medical conditions is gaining in popularity and acceptance every day. While smoking, vaping, edibles, and topical applications are very familiar the use of suppositories is still in the shadows and a relatively unknown alternative. After learning about the success many people claim to have with suppositories I decided to bring this helpful information to the masses. I quickly learned, and was shocked to find, that the effectiveness of cannabis oil (CO) suppositories was a topic of heated debate! Suddenly, my idea of a quick and easy informational post ballooned into an amateur research exercise and science project to identify points in the debate I could confirm, dispel points that didn’t checkout, and develop a better understanding of the topic in general. This post I endeavors to explain many things about CO suppositories; what the debate over effectiveness is about, possible benefits, physiology involved, personal testing experience, what my experience proved to me, and what a blood test showed about absorption.