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Quixote1818

Quixote1818's Journal
Quixote1818's Journal
July 31, 2020

Schools Reopening

He makes some interesting points, especially the one about American kids not being nearly as healthy as kids in other countries. Many are high risk with their health.

July 30, 2020

Don of the Dead

July 30, 2020

LOL This didn't age well: Biden accused Trump of trying to delay the election. He should know better

Henry Olsen 2020-04-24 Originally in the Washington Post

Former vice president Joe Biden’s unfounded accusation Thursday that President Trump wants to delay November’s election was not only clearly over the line but also unmasks how low the supposedly moderate Biden will go to win.

Biden said in an online fundraiser, “Mark my words, I think he is going to try to kick back the election somehow.” As the former chairman of the Senate Judiciary Committee, Biden surely knows that Trump cannot and will not delay the election. The election date is set in law; Trump cannot change it without Congress’s consent. The election itself is run by the states, not the federal government, so there’s no bureaucracy Trump could corral to implement any order delaying the vote. Such an order would surely be challenged in court, and it’s inconceivable that the Supreme Court would uphold such a blatantly unconstitutional act.

Nonetheless, Biden chose to taint the president essentially with a charge of treason. One would hope that this baseless statement could be excused as just another one of Biden’s increasingly frequent verbal hiccups. But Biden said other things Thursday night that show he believes Trump is a disloyal wannabe dictator.

More: https://www.msn.com/en-ca/news/newspolitics/opinions-joe-biden-accused-trump-of-trying-to-delay-the-election-he-should-know-better/ar-BB139y8f

July 30, 2020

A response to the Yale professor who says hydroxychloroquine will save lives

Newsweek recently published an opinion piece by Professor Harvey Risch. Here is a response to that article:


Hydroxychloroquine to treat COVID-19: Evidence can’t seem to kill it
Despite the accumulating negative evidence showing that hydroxychloroquine doesn’t work against COVID-19, activists continue to promote it as a way out of the pandemic. This week, the AAPS and a Yale epidemiologist joined the fray with embarrassingly bad arguments.

David Gorski on July 27, 2020

I find it odd at this juncture in late July that I’ve been writing about a certain drug that was touted as a “miracle cure” for COVID-19 as far back as March. I am referring, of course, to hydroxychloroquine, an anti-malarial drug that also has immunomodulatory effects that make it also useful to treat various autoimmune diseases, such as systemic lupus erythematosus. It’s a drug that, despite the lack of evidence for its efficacy and the continued publication of negative studies testing its efficacy against the disease, just won’t die. Truly, hydroxychloroquine is the Jason Voorhees of drugs, at least with respect to COVID-19. After each new study showing it to be ineffective, it always seems to rise, just as Jason always comes back for another round of killing after seemingly having died at the end of the previous movie.

The hypothesis that antimalarial drugs might be effective treatments for COVID-19 originated in Wuhan, China during the early phase of the pandemic in January. There, Chinese researchers reported that none of their 80 patients with lupus erythematosus who were taking hydroxychloroquine went on to become infected with SARS-CoV-2. As a result of that and old evidence of antiviral activity for the drugs, they became interested in using these antimalarial drugs to treat COVID-19. (Never mind that immunosuppressed patients are exactly the patients most likely to assiduously follow the recommendations of public health authorities during a pandemic.) A number of clinical trials were registered, and, based on anecdotal reports and small clinical trials (nearly all of which are as yet unpublished), in February the Chinese government published an expert consensus recommending CQ or HCQ for patients with COVID-19. Soon after, a number of nations followed suit. From there, a French “brave maverick scientist” named Didier Raoult latched onto the drug as the “answer” to the COVID-19 pandemic, publishing risibly bad studies claiming to show its efficacy. Tech bros such as Elon Musk discovered the claims about hydroxychloroquine and Raoult’s bad science, leading to Donald Trump Tweeting favorably about his study and, ultimately, to the FDA issuing an emergency use authorization for the drug to treat COVID-19.

Since then, there has been a drip-drip-drip of negative studies of hydroxychloroquine, some studies observational, but, increasingly, many being randomized clinical trials, such as the publication of a randomized controlled clinical trial of the drug as post-exposure prophylaxis that was entirely negative. This was followed by two more, first, a Spanish post-exposure prophylaxis trial that was also negative. Then there was the Recovery Trial from the UK, which failed to find a benefit from hydroxychloroquine in hospitalized patients treated with the drug, leading to the revocation of the FDA’s original ill-advised EUA.

More: https://sciencebasedmedicine.org/hydroxychloroquine-to-treat-covid-19-evidence-cant-seem-to-kill-it/

July 29, 2020

Large Brazil Study: Brazil study finds no hydroxychloroquine benefit for COVID-19

July 23, 2020, 6:54 PM
Rio de Janeiro (AFP) - A study published Thursday on the use of hydroxychloroquine in Brazil to treat COVID-19 found the drug ineffective, the latest blow to President Jair Bolsonaro's push for its widespread use.

The clinical trial, conducted at 55 hospitals across Brazil and published in the New England Journal of Medicine, tested whether hydroxychloroquine improved the condition of patients with mild to moderate cases of COVID-19, alone or in combination with the antibiotic azithromycin.

Bolsonaro's government has recommended since May that doctors in Brazil's public health system prescribe hydroxychloroquine or the related anti-malaria drug chloroquine, plus azithromycin, from the onset of symptoms of the new coronavirus.

Like US President Donald Trump, whom he admires, Bolsonaro has touted hydroxychloroquine as a treatment for COVID-19.

The far-right leader is even taking the drug himself, after coming down with the virus earlier this month.

However, a slate of randomized controlled trials (RCTs), considered the gold standard for clinical investigation, have found the drug is ineffective against coronavirus and has potentially damaging side effects.

The Brazilian RCT reached the same conclusion.

Brazil has essentially become the world's biggest testing ground for the drugs because of the Bolsonaro government's policy.

"Among patients hospitalized with mild-to-moderate COVID-19, the use of hydroxychloroquine, alone or with azithromycin, did not improve clinical status at 15 days as compared with standard care," said the study, by doctors and researchers from a group called Coalition COVID-19 Brazil.

The group's members comprise two research institutes and six hospitals, including Albert Einstein Hospital in Sao Paulo, considered one of the best in Latin America.

The study, carried out on 667 patients, also found those on hydroxychloroquine developed clinical markers that increased their risk for heart and liver problems.

More: https://news.yahoo.com/brazil-study-finds-no-hydroxychloroquine-benefit-covid-19-005415925.html

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