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Roland99

(53,342 posts)
1. Here's the best part
Thu Jul 23, 2020, 05:46 PM
Jul 2020

Given the above information, the use of supplemental melatonin as a treatment to overcome a COVID-19 infection is justified. Exogenously administered melatonin reverses aerobic glycolysis by repressing both HIF-1? and mTOR thereby disinhibiting PDC activity and allowing acetyl-coenzyme A synthesis which also ensures locally-produced melatonin production [13]. The functionally re-instated mitochondria-generated melatonin in combination with the parenteral melatonin provides a formidable weapon to reduce the cytokine storm as well as its damaging consequences thereby relieving the signs of a COVID-19 infection.

The anti-inflammatory and antioxidant actions of melatonin in protecting the lungs from damage in many experimental models that involve inflammation or oxidative stress (or both) is well documented [14]. Moreover, melatonin has anti-viral actions against viruses other than COVID-19 [15,16]. The collective data, in addition to its very high safety profile, indicate that melatonin would be effective as a treatment for COVID-19 and support the recommendation of the published reports that encourage its use for this purpose [[3], [4], [5], [6], [7]]. Melatonin is inexpensive, non-toxic over a very wide dose range, has a long shelf-life and can be self-administered which is a major advantage when large numbers of individuals are involved. Thus, the use of melatonin to mitigate the COVID-19 pandemic would be feasible and a socially-responsible measure to attempt.

Here's the best part Roland99 Jul 2020 #1
Thx for the detailed explanation!! Thekaspervote Jul 2020 #4
Melatonin?? The stuff I get from the vitamin wall? Or the health food store? No scrip, no vaccine? niyad Jul 2020 #11
Exactly my first thought as well at140 Jul 2020 #15
Translation? Faux pas Jul 2020 #2
If you use Melatonin as a sleep aid, better go buy up all you can NOW... Moostache Jul 2020 #13
Thank you Faux pas Jul 2020 #41
You just introduced me to ashwagandha.. Cha Jul 2020 #52
Your welcome Faux pas Jul 2020 #53
Good information exchange on DU! Cha Jul 2020 #59
Glad Faux pas Jul 2020 #60
I'm happy it's helped you.. I'm anxiously awaiting my bottle.. Cha Jul 2020 #61
PS Faux pas Jul 2020 #42
So any melatonin supplement from the drug store or Eliot Rosewater Jul 2020 #3
The best way to take melatonin is sublingual, faster better absorption Thekaspervote Jul 2020 #6
for the vast majority of folks who have no idea what that means qazplm135 Jul 2020 #10
Oh so no submarine needed? nt awesomerwb1 Jul 2020 #23
That's what I take. Get it at Costco. Nevilledog Jul 2020 #43
That's how I take it.. spray melatonin every other Cha Jul 2020 #51
Costco is probably safe Miguelito Loveless Jul 2020 #8
Had to look for this link Miguelito Loveless Jul 2020 #22
Of course, one must pay for results. nt Ilsa Jul 2020 #29
My apologies Miguelito Loveless Jul 2020 #34
I posted the top picks Miguelito Loveless Jul 2020 #36
Thank you. You're a mensch! nt Ilsa Jul 2020 #37
Did you pay to get the results? What are the results? Eliot Rosewater Jul 2020 #33
Sorry, they placed them behind the paywall Miguelito Loveless Jul 2020 #35
That's what I use, the Natrol but 10mg.... Kahuna Jul 2020 #24
This is what I use as well. n/t ChazII Jul 2020 #55
That's the good stuff. I tried other brands and dosages before I settled. Kahuna Jul 2020 #57
My neurologist is the ChazII Jul 2020 #58
Really good news! Thekaspervote Jul 2020 #5
I Use Melatonin to Help me Sleep Stallion Jul 2020 #7
So do I. Love it. Goodheart Jul 2020 #12
Leaves You a Little Foggy in the Morning-but after 30 Minutes I'm good Stallion Jul 2020 #14
Only problem I've had with it is, my eyes are a tad dry when I wake up..... a kennedy Jul 2020 #17
I do much less than that. 3/10 of a milligram Goodheart Jul 2020 #21
Bookmarking. Should we be taking melatonin supplements EllieBC Jul 2020 #9
More as a treatment but taking it could make you less susceptible at140 Jul 2020 #18
Melatonin is good for you in many ways. Just research it. triron Jul 2020 #40
Sounds more scientific than kimchi! LeftInTX Jul 2020 #16
I take it every night to help me sleep. leftyladyfrommo Jul 2020 #19
Well at least FLOTUS is good for something. Voltaire2 Jul 2020 #20
?????? niyad Jul 2020 #25
Some folks call her melatonin MissB Jul 2020 #26
Ahh. Much more polite than what I call her. niyad Jul 2020 #28
Same. MissB Jul 2020 #31
melanoma and malaria are the polite terms. niyad Jul 2020 #32
I thought she was Melanomia jmbar2 Jul 2020 #48
hmmm. I googled "melatonin covid treatment" (without the quotes) gristy Jul 2020 #27
I've had to increase to 10 mg oswaldactedalone Jul 2020 #30
Many doctors say 10 mg is fine. I usually take anywhere from 5 or 6 mg up to about 10. triron Jul 2020 #39
This is great news. I and my gf take melatonin every night. I take more than she. triron Jul 2020 #38
I also use it for sleep some nights myccrider Jul 2020 #44
This is from the description of the study: triron Jul 2020 #45
Thanks for the info myccrider Jul 2020 #47
Cool. I used to take it for insomnia mvd Jul 2020 #46
Same thing with me, it quit working but Raine Jul 2020 #50
Already taking Vitamin D,Vitamin C immunity boost and Zinc everyday helpisontheway Jul 2020 #49
Me too. Sometimes add astragulus. Also take an immune senescence formula (by Life Extension) triron Jul 2020 #54
This is the immune booster I take helpisontheway Jul 2020 #56
Never did I ever expect to see a post like this on DU! But thanks! I think.... nt LAS14 Jul 2020 #62
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