http://www.the-scientist.com/?articles.view/articleNo/46237/title/-Human-Genome-Project-Write--Unveiled/
Human Genome Project-Write Unveiled
A proposal to synthesize entire genomesthe subject of a controversial, invitation-only meeting at Harvard last monthis formally presented in Science.
By Jef Akst | June 2, 2016
A team led by New York Universitys Jef Boeke, Harvards George Church, and
Andrew Hessel of the California-based commercial design studio Autodesk Research has published its proposal to synthesize entire genomes from scratch, including those of humans. Called the Human Genome Project-Write (the authors refer to the original HGP as Human Genome Project-Read), the initiative could take 10 years and a minimum of $100 million just to get started, the researchers wrote today (June 2) in Science.
Its essentially a call to action, Hessel told BuzzFeed News. We are suggesting its time to consider a new genome project standing on the foundations of the Human Genome Project.
An underlying goal of the proposed project is to develop technologies to more efficiently and more cheaply write DNA. Tangible products may be slow to follow at first, but writing DNA more cheaply and at large scale will make researchers more efficient and comprehensive in their work, leading to practically unlimited potential for indirect products, Danielle Tullman-Ercek, a biochemical engineer at the University of California, Berkeley, told Nature.
But the proposal was not universally praised. My first thought was so what, Martin Fussenegger, a synthetic biologist at the Swiss Federal Institute of Technology in Zurich, told Nature. I personally think this will happen naturally. Its just a matter of price at the end.
Others are still upset about the discussion that took place at a closed-door meeting last month at Harvard. Synthetic biologist Drew Endy of Stanford University and religious scholar Laurie Zoloth of Northwestern University in Evanston, Illinois, question the scientific value of the plan. Boeke et al.s current proposal should be broadly rejected and not now pursued, Endy told BuzzFeed News in an email.
MOONSHOT SEGMENT (Andrew Hessel, distinguished research scientist at Autodesk, and Ethan Kurzweil, a Bessemer Venture Partners partner):
http://www.bloomberg.com/news/videos/2016-07-14/full-show-bloomberg-west-07-13