At various times in my life.
All through childhood I had a perpetually runny nose, and nobody noticed.
The house was not sealed, not air conditioned, and had dust blowing through it. We also had an 80 pound collie dog who was a house dog with her own sofa to sleep on.
We had totally inadequate window unit air conditioners and a 12-month growing season. Most of the time the house was stifling hot because of a lack of proper air conditioning. It was often too hot to sleep at night.
The dishes, the clothes and the food were clean but the rest of the house wasn't.
We had rats stampeding across the attic at night, and scaring the shit out of me. If dad put out rat poison, a rat would die in a wall and the place would smell horrible. Occasionally I would see a rat walking around in the house at night, skulking around like he owned the joint.
I have had sinus problems, allergic asthma and so forth because I have in the past had a run down immune system.
Auto-immune diseases run in my mother's family and I inherited that tendency from her. The only autoimmune disease that affects me greatly is hypothyroidism.
I don't think your theory of too much cleanliness is applicable in my case.
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