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NNadir

(33,368 posts)
10. I'm afraid it was a long time ago that I considered this question in connection with certain...
Tue Apr 6, 2021, 09:24 PM
Apr 2021

...analytical technology, specifically an LC/MS/MS analytical method for tracing estrogen metabolites. If I recall correctly, it involved a single nucleotide polymorphism, but I'm an old guy and I don't remember where or what specifically it was.

If I recall correctly the issue was with the oxidation of 1,2-diol species, specifically 2-hydroxyestradiol, and 2-hydroxyestrone to give quinones that form DNA adducts, leading to cancer by fitting into the minor groove of DNA in such a way to facilitate adduct formation.

I do know that there was one clinical trial of 2-methoxyextradiol as an anti-cancer therapeutic, but I don't think it went anywhere.

It was a long time ago.

How is it that you know about this allele?

KnR nt intrepidity Apr 2021 #1
Excellent soothsayer Apr 2021 #2
Wonderful! Just one thing. In the end of your post you discuss people who have had covid and mucifer Apr 2021 #3
This is true. In that case, it doesn't hurt. I have had both Moderna injections. When I... NNadir Apr 2021 #4
My BIL was sick with covid for about 10 days back in December. central scrutinizer Apr 2021 #5
Same Claire Oh Nette Apr 2021 #14
So do we need to get a booster in 6 months? wnylib Apr 2021 #18
Not that I know of... Claire Oh Nette Apr 2021 #20
The first vaccinations started in December, wnylib Apr 2021 #21
K&R! SheltieLover Apr 2021 #6
Have you read The Code Breaker, by Walter Isaacson? Staph Apr 2021 #7
No, I'm afraid I haven't read it, but I am familiar with her work of course. NNadir Apr 2021 #11
I highly recommend it. ancianita Apr 2021 #23
Thanks for the book rec. I would have assumed from the title that is was about cryptanalysis! nt eppur_se_muova Apr 2021 #16
;-{) Goonch Apr 2021 #8
I wonder why that last eta in Hellenica has an accent..... love ancient Greek! Karadeniz Apr 2021 #12
It Looks Cool But... PaulnFortWorth Apr 2021 #15
It's Greek To Me Goonch Apr 2021 #19
If you have the time, I'd love to hear more about the COMT gene info that you learned wackadoo wabbit Apr 2021 #9
I'm afraid it was a long time ago that I considered this question in connection with certain... NNadir Apr 2021 #10
Thanks for the info wackadoo wabbit Apr 2021 #22
That's interesting. Based on what I know... NNadir Apr 2021 #24
Chemistry conferences are great IbogaProject Apr 2021 #13
I hope that info about AA immunity gets into the M$M quickly .... eppur_se_muova Apr 2021 #17
I'm not entirely sure if vaccine resistance among any person is necessarily connected... NNadir Apr 2021 #25
Do antivaxers with high blood pressure turn down high blood pressure medicine? Sucha NastyWoman Apr 2021 #26
K & R Thanks! FakeNoose Apr 2021 #27
'African Americans are winners' speak easy Apr 2021 #28
Well, in this case, according to the trial results, any African American who gets the Pfizer... NNadir Apr 2021 #29
This message was self-deleted by its author speak easy Apr 2021 #30
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