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Science
In reply to the discussion: Some news on the variants of SARS-CoV-2 and the effectiveness of the Pfizer vaccine, (good news)! [View all]NNadir
(33,368 posts)10. I'm afraid it was a long time ago that I considered this question in connection with certain...
...analytical technology, specifically an LC/MS/MS analytical method for tracing estrogen metabolites. If I recall correctly, it involved a single nucleotide polymorphism, but I'm an old guy and I don't remember where or what specifically it was.
If I recall correctly the issue was with the oxidation of 1,2-diol species, specifically 2-hydroxyestradiol, and 2-hydroxyestrone to give quinones that form DNA adducts, leading to cancer by fitting into the minor groove of DNA in such a way to facilitate adduct formation.
I do know that there was one clinical trial of 2-methoxyextradiol as an anti-cancer therapeutic, but I don't think it went anywhere.
It was a long time ago.
How is it that you know about this allele?
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Some news on the variants of SARS-CoV-2 and the effectiveness of the Pfizer vaccine, (good news)! [View all]
NNadir
Apr 2021
OP
Wonderful! Just one thing. In the end of your post you discuss people who have had covid and
mucifer
Apr 2021
#3
This is true. In that case, it doesn't hurt. I have had both Moderna injections. When I...
NNadir
Apr 2021
#4
Thanks for the book rec. I would have assumed from the title that is was about cryptanalysis! nt
eppur_se_muova
Apr 2021
#16
I wonder why that last eta in Hellenica has an accent..... love ancient Greek!
Karadeniz
Apr 2021
#12
If you have the time, I'd love to hear more about the COMT gene info that you learned
wackadoo wabbit
Apr 2021
#9
I'm afraid it was a long time ago that I considered this question in connection with certain...
NNadir
Apr 2021
#10
I'm not entirely sure if vaccine resistance among any person is necessarily connected...
NNadir
Apr 2021
#25
Do antivaxers with high blood pressure turn down high blood pressure medicine?
Sucha NastyWoman
Apr 2021
#26