Reply #73: More vaccine reactions reported in small dogs and young animals than older-ML study

[philb]

Vaccine safety in the neonatal period.
Day MJ. J Comp Pathol. 2007 Jul;137 Suppl 1:S51-6. Epub 2007 Jun 11

Results: It would seem that there is a higher prevalence of suspected adverse reactions (SARs) following vaccination in the neonatal period than in adult animals. The range of reported adverse reactions in neonates is broad, and includes: suspected lack of efficacy, mild non-specific and transient illness post-vaccination, and the development of hypersensitivity or autoimmune reactions. The most common reactions in both species are the various clinical manifestations of type I hypersensitivity. That such reactions are most prevalent in small breed dogs, that also make the highest serological responses to vaccination, suggests a case for the formulation of low-dose products for miniature breeds. At least a proportion of neonatal vaccine SARs are related to the use of potent immunological adjuvants in certain products. A recent study in neonatal kittens has confirmed that non-adjuvanted vaccine induces significantly less local vaccine site inflammation than comparable adjuvanted products.
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There is a lot of documentation in the Medical Literature that a signif. percentage of people are immune reactive to thimerosal, and likewise to aluminum. www.melisa.org and lots of Patch test data by allergy docs in the literature.
These are likely to get reactions when vaccinated with high level of something they are immune reactive to; in humans such exposures have been documented to cause autoimmune conditions and other lesser inflammatory conditions. (I've previosuly posted doc.)

But though its harder to assess conditions in animals since they cant talk and aren't commonly tested like infants,
it is known that animals are also subject to immune reactions to immune reactive substance like mercury and aluminum.