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LA TimesThe abrupt shutdown of two aging nuclear reactors that produce a radioisotope widely used in medical imaging has forced physicians in the U.S. and abroad into a crisis, requiring them to postpone or cancel necessary scans for heart disease and cancer, or turn to alternative tests that are not as accurate, take longer and expose patients to higher doses of radiation.
Because of limits on testing produced by the shortage, some patients will undergo heart or cancer surgeries that could have been prevented by imaging, while others will miss needed surgeries because of the lack of testing, said Dr. Michael Graham of the University of Iowa, president of SNM, formerly the Society of Nuclear Medicine. "It's possible that some deaths could occur," he said.
Private companies and government agencies in the U.S. and Canada are looking at new sources of the radioisotope,including the possibility of building new reactors and modifying existing research reactors, but any long-term solution is at least two to three years in the future, experts agree.
The situation is complicated by efforts by the U.S. government, the sole provider of the uranium used in the reactors, to shift to low-enriched uranium from the high-enriched fuel that is now used. Officials fear terrorists could theoretically divert the high-enriched form to the construction of bombs.
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The focus of this shortage is a short-lived radioisotope that most patients have probably never heard of -- technetium-99m, the "m" standing for metastable. With a half-life of only six hours, the isotope allows physicians to examine bones and blood flow, among other things, then quickly disappears from the body, minimizing the dose of radiation received by the patient. Because of its short half-life, the isotope cannot be stockpiled and must be used within a day or two after it is produced.
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http://www.latimes.com/features/health/la-sci-isotope9-2009aug09,0,6453741.story