Glioma vs Resveratrol

[HysteryDiagnosis]

http://clincancerres.aacrjournals.org/cgi/content/full/10/6/2190

The prognosis of patients with malignant glioma, the most common primary brain tumor, is quite poor (1, 2, 3, 4, 5, 6) . Even using multidisciplinary treatment strategies including surgery, radiotherapy, and chemotherapy, the life expectancy of patients with malignant gliomas is usually <1 year from the time of diagnosis, and the 5-year survival rate is <5.5% (1, 2, 3, 4, 5, 6) . Therefore, developing a better therapeutic strategy for malignant brain tumors is mandatory.


>>Resveratrol Suppressed the Expression of VEGF in RT-2 Glioma Cells.
The expression of VEGF in RT-2 glioma cells (treated with various concentrations of resveratrol for 24 h) was studied by RT-PCR (Fig. 6A)Citation . VEGF expression did not significantly change when the glioma cells were treated with low-dose resveratrol, but it was suppressed when they were treated with 10, 25, or 100 µM resveratrol (0.7-, 0.5- and 0.2-fold of the control, respectively). The data indicated that resveratrol suppressed the expression of VEGF in glioma cells in a concentration-dependent manner.<<


Fig. 2. Apoptosis of the RT-2 glioma cells subsequent to resveratrol treatment. After treatment with 0, 0.1, 1, 5, 10, 25, or 100 µM resveratrol for 6, 24, or 48 h, the apoptosis fraction of the RT-2 glioma cells was analyzed using a FACS. Each point is the average of three independent trials (nine determinations for each concentration) and presented as means; bars, SD. One-way ANOVA by Scheffe’s multiple comparison was used for statistical analyses of glioma cell apoptosis induced by various regimens. The significance was accepted as P < 0.05.

[Emillereid]

1. I sure hope he tries a ketogenic diet - there is growing evidence that

it is effective for primary brain cancer: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1819381

http://www.scitizen.com/screens/blogPage/viewBlog/sw_viewBlog.php?idTheme=24&idContribution=427

Sure hope he looks into alternatives.

[BadgerKid]

2. Guess it wouldn't hurt

to imbibe the glass of red wine every now and then.

[HysteryDiagnosis]

3. Nope, we are not talking about casual "food therapy" here, we

are talking about hardcore use of large amounts of supplements to achieve the therapeutic goals that may be possible.













1: Anticancer Res. 2006 Mar-Apr;26(2A):1237-45.Links
Resveratrol suppresses angiogenesis in gliomas: evaluation by color Doppler ultrasound.
Chen JC, Chen Y, Lin JH, Wu JM, Tseng SH.

Department of Surgery, Buddhist Tzu Chi Dalin General Hospital, 2, Ming Shen Road, Dalin, Chia-Yi, Taiwan, ROC.

BACKGROUND: The effects of resveratrol (a natural polyphenol) on angiogenesis in rat gliomas were investigated by color Doppler ultrasound (CDUS). The correlation among the tumor growth rate, macroscopic angiogenesis measured by CDUS and microscopic angiogenesis was assessed by immunohistochemical staining. MATERIALS AND METHODS: Fischer rats were subcutaneously inoculated with rat RT-2 glioma cells and treated with resveratrol for 4 weeks. The tumor size was measured and the animal survival followed. CDUS examination was used to measure tumor blood flow shown as the color Doppler vascularity index (CDVI).

Immunohistochemical staining of CD31 was carried out to assess the microvessel density (MVD) of the tumors. The CDVI, MVD and tumor size were correlated. RESULTS: Rats treated with resveratrol (40 mg/kg/day) had slower tumor growth rates than those of the control groups (p < 0.05). The CDVI, MVD and tumor size were significantly correlated (linear regression, p < 0.0001). CONCLUSION: Resveratrol-suppressed glioma growth was significantly correlated with the inhibition of macroscopic and microscopic angiogenesis.

[Warpy]

4. FYI

http://en.wikipedia.org/wiki/Blood-brain_barrier

Nothing from those nice pretty bottles is going to get anywhere near that tumor.

However, there are a lot of interesting things in the pipeline. An overview is at http://www.stjude.org/stjude/v/index.jsp?vgnextoid=6f2b061585f70110VgnVCM1000001e0215acRCRD&vgnextchannel=bc4fbfe82e118010VgnVCM1000000e2015acRCRD

A site without medicalese is http://rarediseases.about.com/cs/brainneurocancer/a/062601.htm

Antiangiogenesis treatments are undergoing animal trials now.

He's got the best chance of getting into a clinical trial where he is.

[HysteryDiagnosis]

5. Nothing from those nice pretty bottles is going to get anywhere near that tumor.

You may want to reconsider that statement.



1: Brain Res. 2002 Dec 27;958(2):439-47.Click here to read Links
Resveratrol protects against global cerebral ischemic injury in gerbils.
Wang Q, Xu J, Rottinghaus GE, Simonyi A, Lubahn D, Sun GY, Sun AY.

Department of Pharmacology, School of Medicine, M526 Medical Science Bldg, 1 Hospital Drive, University of Missouri-Columbia, Columbia, MO 65212, USA.

Increased oxidative stress has been implicated in the mechanisms of delayed neuronal cell death (DND) following cerebral ischemic insult. In this study, we investigated whether resveratrol, a polyphenolic antioxidant enriched in grape, may ameliorate ischemia-induced neuron cell death. Mongolian gerbils were divided into three groups, namely, sham control, ischemia and ischemia treated with resveratrol. Transient global cerebral ischemia was induced by occlusion of both common carotid arteries (CCA) for 5 min. Resveratrol was injected i.p. (30 mg/kg body weight), either during or shortly after CCA occlusion, and again at 24 h after ischemia. Cerebral blood flow was monitored before and during CCA occlusion using a laser Doppler flowmeter. Brain sections were immuno-stained for neurons, astrocytes and microglial cells.

A time course study was also carried out to assess the bioavailability of resveratrol in serum, liver and brain using high performance liquid chromatography (HPLC). Morphometric measurements indicated extensive DND in the hippocampal CA1 region 4 days after ischemia and that neuron cell death was marked by the increase in reactive astrocytes and microglial cells. Administration of resveratrol, either during or after CCA occlusion, significantly (P<0.05) decreased DND as well as glial cell activation. Analysis of resveratrol after i.p. injection indicated its presence in serum, liver and brain with peak activity at 1, 4 and 4 h, respectively.


This study demonstrated for the first time that resveratrol, a polyphenolic antioxidant, can cross the blood-brain barrier and exert protective effects against cerebral ischemic injury. Copyright 2002 Elsevier Science B.V.

PMID: 12470882

1: Neurosci Lett. 2003 Nov 13;351(2):83-6.Click here to read Links
Resveratrol promotes differentiation and induces Fas-independent apoptosis of human medulloblastoma cells.
Wang Q, Li H, Wang XW, Wu DC, Chen XY, Liu J.

Cancer Institute and Laboratory of Cell Biology and Molecular Genetics, College of Basic Medical Sciences, Dalian Medical University, 116027, Dalian, PR China.

Resveratrol has tumor-suppressive activities in some in vitro and in vivo experimental systems but its effect on medulloblastoma cells is still unknown. In this study, resveratrol was used to treat four human medulloblastoma cell lines (Med-3, UW228-1, -2 and -3) and its effects on cell growth, differentiation and death were examined by multiple approaches. Expression of Fas, FasL and caspase-3 in the cells without and with resveratrol treatments was examined by immunocytochemical staining and mRNA in situ hybridization and the influence of anti-Fas antibody (200 ng/ml) in cell growth and survival was determined as well.

The results demonstrated that resveratrol could suppress growth, promote differentiation and commit its target cells to apoptosis in time- and dose-related fashions. Fas was constitutively expressed but FasL was undetectable in the four lines in spite of resveratrol treatment. Anti-Fas antibody (200 ng/ml) neither inhibited growth nor induced apoptosis of those cell lines. Up-regulated caspase-3 was found in resveratrol-treated populations and appearance of its cleaved form was closely associated with the apoptotic event. These findings suggest for the first time that resveratrol is an effective anti-medulloblastoma agent that kills medulloblastoma cells through a Fas-independent pathway.

[trotsky]

6. One tiny caveat goes with your selective quote in blue.

"This study demonstrated for the first time that resveratrol, a polyphenolic antioxidant, can cross the blood-brain barrier and exert protective effects against cerebral ischemic injury...."

... IN GERBILS.

http://cat.inist.fr/?aModele=afficheN&cpsidt=14356235

Just wanted to clarify.

[WildClarySage]

7. Well as soon as my gerbil gets a brain tumor

I'll know how to cure him!

[HysteryDiagnosis]

8. Pycnogenol has been used in Europe for DECADES for prevention

and TREATMENT of neurological disorders and or degenerative conditions.

http://www.ncbi.nlm.nih.gov/pubmed/15827328?ordinalpos=15&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
These results suggest that multiple signaling pathways may underlie the apoptotic death of U251 glioma induced by resveratrol, which warrants further exploration as an anticancer agent in human glioma.

[cosmik debris]

13. PMID: 15827328 was an experiment in a petri dish

Not a clinical trial on actual humans.

http://mct.aacrjournals.org/cgi/content/full/4/4/554

Dr. Google fails again to do the homework.

[HysteryDiagnosis]

9. Just past the quote in blue... I'm sure you stopped short.....

1: Neurosci Lett. 2003 Nov 13;351(2):83-6.Click here to read Links
Resveratrol promotes differentiation and induces Fas-independent apoptosis of human medulloblastoma cells.
Wang Q, Li H, Wang XW, Wu DC, Chen XY, Liu J.

[trotsky]

10. I did stop short, because your quote applies to the gerbil study.

But hey, you've never let a little thing like accuracy stop you before.

[HysteryDiagnosis]

11. Resveratrol has remarkable effects on glioma cell apoptosis,

as well as many other effects. We are talking about one antioxidant here with remarkable anticancerous effects. This is not to say that resveratrol would help someone overcome a cancerous condition, but only that it has these effects on cancerous cells. What comes of this knowledge in the future one can only guess. If it isn't toxic, and if it doesn't affect traditional treatments (and who knows at this point) why not consider throwing this FOOD EXTRACT into the mix?



Resveratrol-induced apoptotic death in human U251 glioma cells.
Jiang H, Zhang L, Kuo J, Kuo K, Gautam SC, Groc L, Rodriguez AI, Koubi D, Hunter TJ, Corcoran GB, Seidman MD, Levine RA.

William T. Gossett Neurology Laboratories, Henry Ford Health System, Detroit, Michigan 48202, USA.

Resveratrol (trans-3,4',5-trihydroxystilbene) is a naturally occurring polyphenolic compound highly enriched in grapes, peanuts, red wine, and a variety of food sources. Resveratrol has antiinflammatory and antioxidant properties, and also has potent anticancer properties. Human glioma U251 cells were used to understand the molecular mechanisms by which resveratrol acts as an anticancer agent, since glioma is a particularly difficult cancer to treat and eradicate.

Our data show that resveratrol induces dose- and time-dependent death of U251 cells, as measured by lactate dehydrogenase release and internucleosomal DNA fragmentation assays.

Resveratrol induces activation of caspase-3 and increases the cleavage of the downstream caspase substrate, poly(ADP-ribose) polymerase. Resveratrol-induced DNA fragmentation can be completely blocked by either a general caspase inhibitor (Z-VAD-FMK) or a selective caspase-3 inhibitor (Z-DEVD-FMK), but not by a selective caspase-1 inhibitor. Resveratrol induces cytochrome c release from mitochondria to the cytoplasm and activation of caspase-9. Resveratrol also increases expression of proapoptotic Bax and its translocation to the mitochondria. Resveratrol inhibits U251 proliferation, as measured by MTS assay

<3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt>, and induces G0/G1 growth arrest, as determined by flow cytometry. The cyclin-dependent kinase inhibitor, olomoucine, prevents cell cycle progression and resveratrol-induced apoptosis.



These results suggest that multiple signaling pathways may underlie the apoptotic death of U251 glioma induced by resveratrol, which warrants further exploration as an anticancer agent in human glioma.

[trotsky]

12. You are making the simple mistake of over-interpreting studies

and mixing their results.

But hey, you and you alone know how to cure all human brain cancer so I suggest you run right over to Massachusetts and let the Kennedy clan in on the secret. :eyes:

[HysteryDiagnosis]

16. These people are overinterpreting studies. You had better call

them on their stupidity.


http://www.cancer.gov/Templates/drugdictionary.aspx?CdrID=405819

resveratrol
A phytoalexin derived from grapes and other food products with antioxidant and potential chemopreventive activities. Resveratrol induces phase II drug-metabolizing enzymes (anti-initiation activity); mediates anti-inflammatory effects and inhibits cyclooxygenase and hydroperoxidase functions (anti-promotion activity); and induces promyelocytic leukemia cell differentiation (anti-progression activity), thereby exhibiting activities in three major steps of carcinogenesis. This agent may inhibit TNF-induced activation of NF-kappaB in a dose- and time-dependent manner. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)

[trotsky]

17. And if you can explain how that comes close to what you're claiming...

you win a cookie!

[HysteryDiagnosis]

18. What did I claim?? Exactly.

[trotsky]

25. Oh you've learned from your charlatan/fraud masters well.

But it's quite clear from your OP what you intend to link together. No one is fooled by your "innocent" backtracking.

[HysteryDiagnosis]

19. Riddle me this.... if this is such a non-thing, why all the interest, be

candid and truthful for once. Perhaps a reading comprehension course for you.... yes perhaps.


1:
Related Articles, Links
Leone S, Fiore M, Lauro MG, Pino S, Cornetta T, Cozzi R.
Abstract
Resveratrol and X rays affect gap junction intercellular communications in human glioblastoma cells.
Mol Carcinog. 2008 Feb 19.
PMID: 18286483

2:
Related Articles, Links
Lin HY, Tang HY, Keating T, Wu YH, Shih A, Hammond D, Sun M, Hercbergs A, Davis FB, Davis PJ.
Abstract
Resveratrol is pro-apoptotic and thyroid hormone is anti-apoptotic in glioma cells: both actions are integrin and ERK
mediated.
Carcinogenesis. 2008 Jan;29(1):62-9. Epub 2007 Nov 4.
PMID: 17984113

3:
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Kim YA, Kim GY, Park KY, Choi YH.
Abstract
Resveratrol inhibits nitric oxide and prostaglandin E2 production by lipopolysaccharide-activated C6 microglia.
J Med Food. 2007 Jun;10(2):218-24.
PMID: 17651055

4:
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Quincozes-Santos A, Andreazza AC, Nardin P, Funchal C, Gonçalves CA, Gottfried C.
Abstract
Resveratrol attenuates oxidative-induced DNA damage in C6 Glioma cells.
Neurotoxicology. 2007 Jul;28(4):886-91. Epub 2007 Mar 31.
PMID: 17498806

5:
Related Articles, Links
Zhang W, Fei Z, Zhen HN, Zhang JN, Zhang X.
Abstract
Resveratrol inhibits cell growth and induces apoptosis of rat C6 glioma cells.
J Neurooncol. 2007 Feb;81(3):231-40. Epub 2006 Sep 20.
PMID: 17031560

6:
Related Articles, Links
dos Santos AQ, Nardin P, Funchal C, de Almeida LM, Jacques-Silva MC, Wofchuk ST, Gonçalves CA, Gottfried C.
Abstract
Resveratrol increases glutamate uptake and glutamine synthetase activity in C6 glioma cells.
Arch Biochem Biophys. 2006 Sep 15;453(2):161-7. Epub 2006 Jul 28.
PMID: 16904623

7:
Related Articles, Links
Michels G, Wätjen W, Weber N, Niering P, Chovolou Y, Kampkötter A, Proksch P, Kahl R.
Abstract
Resveratrol induces apoptotic cell death in rat H4IIE hepatoma cells but necrosis in C6 glioma cells.
Toxicology. 2006 Aug 15;225(2-3):173-82. Epub 2006 Jun 2.
PMID: 16843582

8:
Related Articles, Links
Zhang P, Li H, Wu ML, Chen XY, Kong QY, Wang XW, Sun Y, Wen S, Liu J.
Abstract
c-Myc downregulation: a critical molecular event in resveratrol-induced cell cycle arrest and apoptosis of human medulloblastoma cells.
J Neurooncol. 2006 Nov;80(2):123-31. Epub 2006 May 25.
PMID: 16724266

10:
Related Articles, Links
Kim YA, Lim SY, Rhee SH, Park KY, Kim CH, Choi BT, Lee SJ, Park YM, Choi YH.
Abstract
Resveratrol inhibits inducible nitric oxide synthase and cyclooxygenase-2 expression in beta-amyloid-treated C6 glioma cells.
Int J Mol Med. 2006 Jun;17(6):1069-75.
PMID: 16685418

11:
Related Articles, Links
Chen JC, Chen Y, Lin JH, Wu JM, Tseng SH.
Abstract
Resveratrol suppresses angiogenesis in gliomas: evaluation by color Doppler ultrasound.
Anticancer Res. 2006 Mar-Apr;26(2A):1237-45.
PMID: 16619530

12:
Related Articles, Links
Arimochi H, Morita K.
Abstract
High salt culture conditions suppress proliferation of rat C6 glioma cell by arresting cell-cycle progression at S-phase.
J Mol Neurosci. 2005;27(3):293-301.
PMID: 16280599

13:
Related Articles, Links
Gagliano N, Moscheni C, Torri C, Magnani I, Bertelli AA, Gioia M.
Abstract
Effect of resveratrol on matrix metalloproteinase-2 (MMP-2) and Secreted Protein Acidic and Rich in Cysteine (SPARC) on human cultured glioblastoma cells.
Biomed Pharmacother. 2005 Aug;59(7):359-64.
PMID: 16084059

14:
Related Articles, Links
Wu ML, Li H, Wu DC, Wang XW, Chen XY, Kong QY, Ma JX, Gao Y, Liu J.
Abstract
CYP1A1 and CYP1B1 expressions in medulloblastoma cells are AhR-independent and have no direct link with resveratrol-induced differentiation and apoptosis.
Neurosci Lett. 2005 Aug 12-19;384(1-2):33-7.
PMID: 15893423

15:
Related Articles, Links
Jiang H, Zhang L, Kuo J, Kuo K, Gautam SC, Groc L, Rodriguez AI, Koubi D, Hunter TJ, Corcoran GB, Seidman MD, Levine RA.
Free Full Text
Resveratrol-induced apoptotic death in human U251 glioma cells.
Mol Cancer Ther. 2005 Apr;4(4):554-61.
PMID: 15827328

16:
Related Articles, Links
Liu J, Wang Q, Wu DC, Wang XW, Sun Y, Chen XY, Zhang KL, Li H.
Abstract
Differential regulation of CYP1A1 and CYP1B1 expression in resveratrol-treated human medulloblastoma cells.
Neurosci Lett. 2004 Jun 17;363(3):257-61.
PMID: 15182955

17:
Related Articles, Links
Laux MT, Aregullin M, Berry JP, Flanders JA, Rodriguez E.
Abstract
Identification of a p53-dependent pathway in the induction of apoptosis of human breast cancer cells by the natural product, resveratrol.
J Altern Complement Med. 2004 Apr;10(2):235-9.
PMID: 15165403

18:
Related Articles, Links
Tseng SH, Lin SM, Chen JC, Su YH, Huang HY, Chen CK, Lin PY, Chen Y.
Free Full Text
Resveratrol suppresses the angiogenesis and tumor growth of gliomas in rats.
Clin Cancer Res. 2004 Mar 15;10(6):2190-202.
PMID: 15041740

19:
Related Articles, Links
Wang Q, Li H, Wang XW, Wu DC, Chen XY, Liu J.
Abstract
Resveratrol promotes differentiation and induces Fas-independent apoptosis of human medulloblastoma cells.
Neurosci Lett. 2003 Nov 13;351(2):83-6.
PMID: 14583387

[trotsky]

24. Please show which of those studies applies to humans in vivo.

You have mastered CTRL-C and CTRL-V, Grasshopper. Now show that you actually UNDERSTAND what you write. You have yet to do so.

[cosmik debris]

26. He forgets so quickly

That he got caught posting abstracts for research that contradicted his position on amalgam.

It is clear that he can't be trusted to read the research, he only reads the abstract and LEAPS to conclusions.

And he thinks we will be fooled by the same trick again. :rofl:

[HysteryDiagnosis]

28. ...

[cosmik debris]

14. in vitro

Not in vivo

Has this stuff ever been tested in humans?

Show us research on humans.

[HysteryDiagnosis]

20. Papers please, WTFU

1:
Related Articles, Links
Leone S, Fiore M, Lauro MG, Pino S, Cornetta T, Cozzi R.
Abstract
Resveratrol and X rays affect gap junction intercellular communications in human glioblastoma cells.
Mol Carcinog. 2008 Feb 19.
PMID: 18286483

2:
Related Articles, Links
Lin HY, Tang HY, Keating T, Wu YH, Shih A, Hammond D, Sun M, Hercbergs A, Davis FB, Davis PJ.
Abstract
Resveratrol is pro-apoptotic and thyroid hormone is anti-apoptotic in glioma cells: both actions are integrin and ERK
mediated.
Carcinogenesis. 2008 Jan;29(1):62-9. Epub 2007 Nov 4.
PMID: 17984113

3:
Related Articles, Links
Kim YA, Kim GY, Park KY, Choi YH.
Abstract
Resveratrol inhibits nitric oxide and prostaglandin E2 production by lipopolysaccharide-activated C6 microglia.
J Med Food. 2007 Jun;10(2):218-24.
PMID: 17651055

4:
Related Articles, Links
Quincozes-Santos A, Andreazza AC, Nardin P, Funchal C, Gonçalves CA, Gottfried C.
Abstract
Resveratrol attenuates oxidative-induced DNA damage in C6 Glioma cells.
Neurotoxicology. 2007 Jul;28(4):886-91. Epub 2007 Mar 31.
PMID: 17498806

5:
Related Articles, Links
Zhang W, Fei Z, Zhen HN, Zhang JN, Zhang X.
Abstract
Resveratrol inhibits cell growth and induces apoptosis of rat C6 glioma cells.
J Neurooncol. 2007 Feb;81(3):231-40. Epub 2006 Sep 20.
PMID: 17031560

6:
Related Articles, Links
dos Santos AQ, Nardin P, Funchal C, de Almeida LM, Jacques-Silva MC, Wofchuk ST, Gonçalves CA, Gottfried C.
Abstract
Resveratrol increases glutamate uptake and glutamine synthetase activity in C6 glioma cells.
Arch Biochem Biophys. 2006 Sep 15;453(2):161-7. Epub 2006 Jul 28.
PMID: 16904623

7:
Related Articles, Links
Michels G, Wätjen W, Weber N, Niering P, Chovolou Y, Kampkötter A, Proksch P, Kahl R.
Abstract
Resveratrol induces apoptotic cell death in rat H4IIE hepatoma cells but necrosis in C6 glioma cells.
Toxicology. 2006 Aug 15;225(2-3):173-82. Epub 2006 Jun 2.
PMID: 16843582

8:
Related Articles, Links
Zhang P, Li H, Wu ML, Chen XY, Kong QY, Wang XW, Sun Y, Wen S, Liu J.
Abstract
c-Myc downregulation: a critical molecular event in resveratrol-induced cell cycle arrest and apoptosis of human medulloblastoma cells.
J Neurooncol. 2006 Nov;80(2):123-31. Epub 2006 May 25.
PMID: 16724266

10:
Related Articles, Links
Kim YA, Lim SY, Rhee SH, Park KY, Kim CH, Choi BT, Lee SJ, Park YM, Choi YH.
Abstract
Resveratrol inhibits inducible nitric oxide synthase and cyclooxygenase-2 expression in beta-amyloid-treated C6 glioma cells.
Int J Mol Med. 2006 Jun;17(6):1069-75.
PMID: 16685418

11:
Related Articles, Links
Chen JC, Chen Y, Lin JH, Wu JM, Tseng SH.
Abstract
Resveratrol suppresses angiogenesis in gliomas: evaluation by color Doppler ultrasound.
Anticancer Res. 2006 Mar-Apr;26(2A):1237-45.
PMID: 16619530

12:
Related Articles, Links
Arimochi H, Morita K.
Abstract
High salt culture conditions suppress proliferation of rat C6 glioma cell by arresting cell-cycle progression at S-phase.
J Mol Neurosci. 2005;27(3):293-301.
PMID: 16280599

13:
Related Articles, Links
Gagliano N, Moscheni C, Torri C, Magnani I, Bertelli AA, Gioia M.
Abstract
Effect of resveratrol on matrix metalloproteinase-2 (MMP-2) and Secreted Protein Acidic and Rich in Cysteine (SPARC) on human cultured glioblastoma cells.
Biomed Pharmacother. 2005 Aug;59(7):359-64.
PMID: 16084059

14:
Related Articles, Links
Wu ML, Li H, Wu DC, Wang XW, Chen XY, Kong QY, Ma JX, Gao Y, Liu J.
Abstract
CYP1A1 and CYP1B1 expressions in medulloblastoma cells are AhR-independent and have no direct link with resveratrol-induced differentiation and apoptosis.
Neurosci Lett. 2005 Aug 12-19;384(1-2):33-7.
PMID: 15893423

15:
Related Articles, Links
Jiang H, Zhang L, Kuo J, Kuo K, Gautam SC, Groc L, Rodriguez AI, Koubi D, Hunter TJ, Corcoran GB, Seidman MD, Levine RA.
Free Full Text
Resveratrol-induced apoptotic death in human U251 glioma cells.
Mol Cancer Ther. 2005 Apr;4(4):554-61.
PMID: 15827328

16:
Related Articles, Links
Liu J, Wang Q, Wu DC, Wang XW, Sun Y, Chen XY, Zhang KL, Li H.
Abstract
Differential regulation of CYP1A1 and CYP1B1 expression in resveratrol-treated human medulloblastoma cells.
Neurosci Lett. 2004 Jun 17;363(3):257-61.
PMID: 15182955

17:
Related Articles, Links
Laux MT, Aregullin M, Berry JP, Flanders JA, Rodriguez E.
Abstract
Identification of a p53-dependent pathway in the induction of apoptosis of human breast cancer cells by the natural product, resveratrol.
J Altern Complement Med. 2004 Apr;10(2):235-9.
PMID: 15165403

18:
Related Articles, Links
Tseng SH, Lin SM, Chen JC, Su YH, Huang HY, Chen CK, Lin PY, Chen Y.
Free Full Text
Resveratrol suppresses the angiogenesis and tumor growth of gliomas in rats.
Clin Cancer Res. 2004 Mar 15;10(6):2190-202.
PMID: 15041740

19:
Related Articles, Links
Wang Q, Li H, Wang XW, Wu DC, Chen XY, Liu J.
Abstract
Resveratrol promotes differentiation and induces Fas-independent apoptosis of human medulloblastoma cells.
Neurosci Lett. 2003 Nov 13;351(2):83-6.
PMID: 14583387

[cosmik debris]

23. You posted the titles of articles, not links

Please post the links to those articles so that others can read them.

[cosmik debris]

27. PMID: 15041740 is a study of RATS

It is not a study of humans.

Once again you are being deceptive and dishonest with your posts.

Once again you have diminished your credibility because you don't even bother to read the research you post.

You will never graduate from Google U. if you don't do your homework.

Laziness is no excuse.

[cosmik debris]

29. PMID: 15165403 is an in vitro study

Once again you are dishonest and deceitful with your references.

[cosmik debris]

30. PMID: 15182955 is also in vitro

Thats three time you have been dishonest in your posts. And that's just one post!

You'll never graduate fro Google U. if you keep cheating on your homework.

[cosmik debris]

31. Guess what--PMID: 15827328 is also in vitro

Do you have ANY studies of this drug in vivo?

Why can't you honestly confess that you are blowing smoke and being deceitful and dishonest?

[cosmik debris]

32. What a Surprise! PMID: 15893423 is bogus too!

Another in vitro study.

The more I research your link, the more dishonest you appear.

How many more should I research?

[cosmik debris]

33. PMID: 16084059 even says IN YOUR POST that it is in vitro.

"Effect of resveratrol on matrix metalloproteinase-2 (MMP-2) and Secreted Protein Acidic and Rich in Cysteine (SPARC) on human cultured glioblastoma cells."

Do you know what "cultured cells" are?

Your dishonesty is astounding. But your ignorance and audacity are dumbfounding!

[cosmik debris]

34. PMID: 16280599 is another RAT study and it is in vitro!

"High salt culture conditions suppress proliferation of rat C6 glioma cell by arresting cell-cycle progression at S-phase."

Another bogus post.

[cosmik debris]

35. PMID: 16619530 is another rat study

You just can't get it right can you?

[cosmik debris]

36. More dishonesty and deceit

PMID: 16685418 is in vitro too.

Are you ready to cry uncle?

I can keep this up all day.

[cosmik debris]

37. How many of these do I have to debunk? PMID: 16724266

PMID: 16724266 is another in vitro test.

[cosmik debris]

38. PMID: 16843582 is another rat test.

You just can't get a break, can you.

[cosmik debris]

39. Who would ever guessed? PMID: 16904623 is in vitro

So far I have debunked over half of your sources.

Are you ready to cry uncle?

[cosmik debris]

40. Do you even read this bogus crap before you post?

PMID: 17031560

"Resveratrol inhibits cell growth and induces apoptosis of rat C6 glioma cells."

Here is a clue: rats are NOT humans.

Here is another clue: cell tests are NOT in vivo.

Do you understand that?

[cosmik debris]

41. PMID: 17498806 More bogus crap

"The objective of the present study was to investigate the genoprotective effects of resveratrol under conditions of oxidative stress induced by hydrogen peroxide in C6 glioma cells."

This is starting to be FUN!

[cosmik debris]

42. Again, rats are NOT humans, cell tests are NOT in vivo!

PMID: 17651055

"Exposure of cultured rat C6 astroglioma cells to LPS increased their release of NO and PGE2 and their inducible expression of NO synthase and cyclooxygenase-2, all of which were significantly inhibited by resveratrol pretreatment."

[trotsky]

43. You. Kick. ASS.

Bravo for tracking down every bogus irrelevant cut & paste. :yourock: :applause:

You've got more constitution than I do!

[cosmik debris]

45. I'm not through yet.

He cited 18 studies as being in vivo human tests. If I am able I will debunk all 18.

Some information is harder to find than others.

[cosmik debris]

44. Had enough yet? PMID: 17984113 is another bogus citation.

It is another in vitro test.

You may apologize any time you wish.

[cosmik debris]

46. PMID: 18286483--Can you guess what is wrong with this one?

"In this study we have looked into whether resveratrol is able to modulate cell cycle progression in human glioblastoma cells and to regulate GJs expression in cancer cells. With this aim in mind we have performed a cytofluorimetric multiparameter assay to quantify the presence of GJs in U87 glioma cells treated with resveratrol and/or X rays."

Have you figured it out yet?

Here is a clue: CELL TESTS ARE NOT IN VIVO TESTS.

[cosmik debris]

47. Same song, 17th verse

"In this study, resveratrol was used to treat four human medulloblastoma cell lines (Med-3, UW228-1, -2 and -3) and its effects on cell growth, differentiation and death were examined by multiple approaches."

PMID: 14583387

[cosmik debris]

48. Another rat study

"the influence of high salt culture conditions on the growth of rat C6 glioma cells was examined."

And of course, it is also in vitro, not in vivo.

PMID: 16280599

[cosmik debris]

49. Summary: 0 of 18 citations (you left out #9)

0 of 18 citations were in vivo tests on humans.

That is the second time I have caught you using bogus citations to support your ignorant ideas.

You have no credibility left.

You may apologize now.

[SidDithers]

55. Bookmarking this thread...

'cause that was freakin' awesome :applause:

Sid

[cosmik debris]

50. I suppose your silence is apology enough.

But I doubt that you have learned yet. (even after being caught TWICE!)

And you will probably try this same bullshit again.

So remember this thread because I will remind you next time you post bogus citations.

[trotsky]

51. It's certainly the only kind of apology you have any chance of getting.

This thread is going in my bookmarks for sure.

[cosmik debris]

52. Add this one too. It is the first time I caught him blowing smoke

http://www.democraticunderground.com/discuss/duboard.php?az=show_topic&forum=222&topic_id=35375#35442

And next time he wants to post the titles of a bunch of studies he hasn't read, we'll remind him that he has lost all credibility by being so astoundingly dishonest.

[hvn_nbr_2]

54. Thanks for the wikipedia link

I didn't really know how the b-b barrier worked although I suspected something along those lines, without knowing enough to figure out the details. The explanation in that article is pretty good. (Sometimes medical articles in wikipedia require a post-doc in biochemistry plus an M.D. degree to understand what they're saying.)

Your statement Nothing from those nice pretty bottles is going to get anywhere near that tumor seems to suggest that you know for a fact that resveratrol does not cross the b-b barrier. Is that, in fact, an established fact? If it is, then a whole lot of electrons could have been saved in the rest of this thread with unproductive back-and-forth.

(I'm sure both sides of the back-and-forth would disagree since they all undoubtedly think that they've proven their point beyond any possibility of doubt by any reasonable person. :shrug: That's the way these arguments seem to go.)

[cosmik debris]

15. So far your links prove that it cures petri dishes, rats, and gerbils.

Please post links to studies done on humans.

[HysteryDiagnosis]

21. Link for us humans.....

http://www.democraticunderground.com/discuss/duboard.php?az=show_mesg&forum=222&topic_id=36018&mesg_id=36073

[cosmik debris]

22. There are NO LINKS in that post

Please post links.

[BuddhaGirl]

53. very interesting!

I have been looking at resveratrol lately - it's very good antioxidant for the heart as well. It's also supposed to help reduce the toxic effects of ischemia in the brain after a stroke.

The highest concentration of resveratrol is found in Japanese knotweed.