The ability to create stem cell treatments without using embryos is a step closer, say researchers.
A UK and Canadian team have manipulated human skin cells to act like embryonic stem cells without using viruses - making them safer for use in humans.
The cells are reprogrammed by the insertion of four genes which are then removed once the process is complete, they report in Nature.
While a significant step it is early days, the Edinburgh-based experts say.
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Study leader Dr Keisuke Kaji, from the Medical Research Council Centre for Regenerative Medicine at the University of Edinburgh, said nobody, including himself, had thought it was really possible.
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