Sep. 11, 2008
The underdevelopment of a specific region in the brain may lead to schizophrenia in individuals. According to research published today in BioMed Central’s open access journal Molecular Brain, dentate gyrus, which is located in the hippocampus in the brain and thought to be responsible for working memory and mood regulation, remained immature in an animal model of schizophrenia.
First, the team investigated behaviors by conducting a systematic and well-defined behavioral test battery with alpha-CaMKII mutant mice, an animal model of schizophrenia. These mice showed abnormal behaviors similar to those of schizophrenic patients.
Next, the team found the dentate gyrus neurons in hippocampus of the brain of these mice were not matured morphologically and physiologically. By a gene expression analysis, changes of gene expression related to the maturation of dentate gyrus neurons were also found in the brains of schizophrenic patients.
Taken together, the immaturity of the dentate gyrus may be an underlying cause for schizophrenia.
http://www.sciencedaily.com/releases/2008/09/080910133341.htm