Even More New Proof Cannabinoids Kill Cancer Cells (Breast Cancer)

[BakedAtAMileHigh]

from the journal "Molecular Cancer":
http://www.molecular-cancer.com/content/9/1/196

Research
Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition

Maria M Caffarel email, Clara Andradas email, Emilia Mira email, Eduardo Perez-Gomez email, Camilla Cerutti email, Gema Moreno-Bueno email, Juana M Flores email, Isabel Garcia-Real email, Jose Palacios email, Santos Manes email, Manuel Guzman email and Cristina Sanchez email

Molecular Cancer 2010, 9:196doi:10.1186/1476-4598-9-196
Published: 22 July 2010
Abstract (provisional)

Background

ErbB2-positive breast cancer is characterized by highly aggressive phenotypes and reduced responsiveness to standard therapies. Although specific ErbB2-targeted therapies have been designed, only a small percentage of patients respond to these treatments and most of them eventually relapse. The existence of this population of particularly aggressive and non-responding or relapsing patients urges the search for novel therapies. The purpose of this study was to determine whether cannabinoids might constitute a new therapeutic tool for the treatment of ErbB2-positive breast tumors. We analyzed their antitumor potential in a well established and clinically relevant model of ErbB2-driven metastatic breast cancer: the MMTV-neu mouse. We also analyzed the expression of cannabinoid targets in a series of 87 human breast tumors.

Results

Our results show that both Delta9-tetrahydrocannabinol, the most abundant and potent cannabinoid in marijuana, and JWH-133, a non-psychotropic CB2 receptor-selective agonist, reduce tumor growth, tumor number, and the amount/severity of lung metastases in MMTV-neu mice. Histological analyses of the tumors revealed that cannabinoids inhibit cancer cell proliferation, induce cancer cell apoptosis, and impair tumor angiogenesis. Cannabinoid antitumoral action relies, at least partially, on the inhibition of the pro-tumorigenic Akt pathway. We also found that 91% of ErbB2-positive tumors express the non-psychotropic cannabinoid receptor CB2.
Conclusions

Taken together, these results provide a strong preclinical evidence for the use of cannabinoid-based therapies for the management of ErbB2-positive breast cancer.

[opihimoimoi]

1. DELTA DAWN....whats that High you got on....???

http://www.youtube.com/watch?v=DmSZINm3GKc

[DeSwiss]

2. K&R

Thanks, I'll add this one to my list:

The below research links are to articles, scientific studies and abstracts which report that the tetrahydrocannabinol and cannabinoids in marijuana can halt the spread the MRSA bacteria and numerous other types of cancer cells -- including:

MRSA: http://www.webmd.com/news/20080904/marijuana-chemicals-may-fight-mrsa

Prostate Cancer: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T36-3XFTGPR-X&_coverDate=09%2F24%2F1999&_alid=422767905&_rdoc=1&_fmt=&_orig=search&_qd=1&_cdi=4938&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=1c29920efb1acb800723560310e9004e

Breast Cancer: http://mct.aacrjournals.org/cgi/content/abstract/6/11/2921

Lung Cancer: http://www.nature.com/onc/journal/v27/n3/abs/1210641a.html

Pancreatic Cancer: http://cancerres.aacrjournals.org/cgi/content/abstract/66/13/6748

Brain Cancer: http://www.ncbi.nlm.nih.gov/pubmed/16804518

And in addition to the cancer research, here's a report about a French study that found that cannabidiol in marijuana may prevent the development of prion diseases such as BSE because it inhibits the accumulation of prion proteins in infected mice and sheep. Bovine Spongiform Encephalopathy: http://www.showmethefacts.org/medical-marijuana-facts/cannabidiol/

:)

[lbrtbell]

3. LOL!

So all these women who smoke pot and get breast cancer can be explained how...?

[BakedAtAMileHigh]

4. Got Science?

I would love to see your peer reviewed literature.

Any time.

[Johonny]

5. just because it promotes cell death, doesn't mean it makes you immune from cancer.

any more than just because your uncle smokes 2 cartons of cigarettes a day and live to 90 mean that smoking doesn't increase your probability of getting cancer. You can live an incredibly healthy lifestyle and still get cancer. Low probability events happen all the time. While there are negative health effects to taking THC, there are clearly some health benefits. Few life style choices are not without potential gains and losses. If one had cancer one might weigh the negative effects of THC much more differentially than if one didn't. Either way this papers result is pretty backed up in the science literature now.

[RainDog]

6. the person to whom you responded

also claims that it was bad to repeal prohibition. (edited - oops)

good luck trying to reason with someone by the use of medical studies this person might actually have to read.

[Warren DeMontague]

7. Nyuk Nyuk Nyuk Harr Harr Harr

You were on the Debate team at Yale, weren't you? Come on, admit it.

[eShirl]

8. By all means, show us the statistics.

[Hawkeye-X]

9. My aunt should have been smoking it

She was a cancer generator. Survived breast cancer, but died of ovarian cancer.

She had the BRCA1 mutation

So does my sister - so she had total hysterectomy after 3 children

Mom wants me tested, but not sure if I should do it.

[Confusious]

10. I doubt just smoking would have helped

In tests like these it's in a more concentrated and pure form, because otherwise the test means nothing.