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Related: Editorials & Other Articles, Issue Forums, Alliance Forums, Region ForumsChloroquine phosphate has shown apparent efficacy in treatment of COVID-19
Last edited Thu Mar 12, 2020, 03:50 PM - Edit history (1)
Has there been a run on chloroquine yet? Forewarned is forearmed........... ??
https://www.ncbi.nlm.nih.gov/m/pubmed/32074550/
Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies.
Abstract
The coronavirus disease 2019 (COVID-19) virus is spreading rapidly, and scientists are endeavoring to discover drugs for its efficacious treatment in China. Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China. The drug is recommended to be included in the next version of the Guidelines for the Prevention, Diagnosis, and Treatment of Pneumonia Caused by COVID-19 issued by the National Health Commission of the People's Republic of China for treatment of COVID-19 infection in larger populations in the future.
ETA: There are recent posts that question the above. Please see https://www.democraticunderground.com/100213042640
So some additional links:
https://www.sciencedirect.com/science/article/pii/S0166354220301145
https://www.nature.com/articles/d41587-020-00003-1
https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-2-69
We report, however, that chloroquine has strong antiviral effects on SARS-CoV infection of primate cells. These inhibitory effects are observed when the cells are treated with the drug either before or after exposure to the virus, suggesting both prophylactic and therapeutic advantage. In addition to the well-known functions of chloroquine such as elevations of endosomal pH, the drug appears to interfere with terminal glycosylation of the cellular receptor, angiotensin-converting enzyme 2. This may negatively influence the virus-receptor binding and abrogate the infection, with further ramifications by the elevation of vesicular pH, resulting in the inhibition of infection and spread of SARS CoV at clinically admissible concentrations
Xipe Totec
(43,890 posts)intrepidity
(7,294 posts)2naSalit
(86,579 posts)Tuesday when my $$ arrives to go shopping. I'm making my list now though.
Blueplanet
(253 posts)Quinine is used to treat malaria - it is an antimalarial drug. Had to look it up.
Xipe Totec
(43,890 posts)sl8
(13,749 posts)From Wikipedia, so take it with a grain of salt (or follow the sources):
https://en.m.wikipedia.org/wiki/Tonic_water
Tonic water (or Indian tonic water) is a carbonated soft drink in which quinine is dissolved. Originally used as a prophylactic against malaria, tonic water usually now has a significantly lower quinine content and is consumed for its distinctive bitter flavor, though it is nowadays also often sweetened. It is often used in mixed drinks, particularly in gin and tonic.
[...]
Quinine content
[...]
In the United States, the US Food and Drug Administration (FDA) limits the quinine content in tonic water to 83 ppm[3] (83 mg per liter if calculated by mass), while the daily therapeutic dose of quinine is in the range of 5001000 mg,[4] and 10 mg/kg every eight hours for effective malaria prevention (2100 mg daily for a 70 kg adult).[5] It is often recommended as a relief for leg cramps, but medical research suggests some care is needed in monitoring doses.[6] Because of quinine's risks, the FDA cautions consumers against using "off-label" quinine drugs to treat leg cramps.[7]
[...]
[Footnotes:]
3. "21 CFR §172.575 Quinine" (PDF). Retrieved 15 December 2008.
4. "Quinine". Tropical Plant Database. Section "Current practical uses": Raintree Nutrition. Retrieved 10 July 2011.
5. Achan, J (2011). "Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria". Malaria Journal. 10 (144): 112. doi:10.1186/1475-2875-10-144. PMC 3121651. PMID 21609473.
[...]
More at link.
Recursion
(56,582 posts)Still popular in India
cwydro
(51,308 posts)My mom, god rest her, is raising a glass somewhere!
Laura PourMeADrink
(42,770 posts)captain queeg
(10,185 posts)Pretty sure I tossed them. Didnt worry much about malaria in Afghanistan.
Leghorn21
(13,524 posts)...meanwhile, I did a search a few days back, and found an article that said that licorice root has shown to possess anti-viral properties, hmmm, and vitamins A, C and E are good for our lung health
Thanks and carry on, i!! Keep telling us what you know!!
on edit: here's the link, which of course I can't really read, it's mighty scholarly!:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629407/
meow2u3
(24,761 posts)or other licorice items if you can tolerate them. I have no tolerance for table sugar or fructose, so I can't eat them without suffering later.
Question is, are there any sugar free licorice stuff I can pick up?
sdfernando
(4,935 posts)At many stores....also DGL is good and chewable.
meow2u3
(24,761 posts)The Vitamin Store carries it, thank God. It costs about $10 for 100 capsules. You might want to go there if you can't find it elsewhere.
scarletwoman
(31,893 posts)and may contain no real licorice at all.
meow2u3
(24,761 posts)I've seen "licorice flavored" candies and checked the ingredients only to discover the anise flavoring.
scarletwoman
(31,893 posts)flavored with anise, I know it's safe for me to eat.
duhneece
(4,112 posts)Mmmmm. Helps with ulcers and viral infections.
Well good day to have done so. Normally you'd be bored out of your mind by my posts.
Progressive dog
(6,900 posts)in the USA, probably made in China.
Leghorn21
(13,524 posts)a la izquierda
(11,791 posts)And you dont want to take it unless absolutely necessary. The side effects can be brutal. Ive had to take it while traveling in Central and South America. I felt like hell.
Leghorn21
(13,524 posts)Thank you!
sinkingfeeling
(51,453 posts)Atovaquone-Proguanl.
milestogo
(16,829 posts)Joinfortmill
(14,417 posts)indigovalley
(113 posts)Jeez, I have Lupus and take Hydroxychloroquine 200 mg a day. Does that mean I have extra protection against Covid 19?
Drahthaardogs
(6,843 posts)I wonder what the dosing protocol is
uponit7771
(90,335 posts)MrsCoffee
(5,801 posts)I will ask my doctor next month.
Mendocino
(7,488 posts)Quinine is the tonic, as in gin and tonic. The amount used in tonic for drinks is far too weak to be effective. Tonic syrup can be bought at places like Walmart and Target. The bark of the cinchona plant is the source.
Quinine has its own risks.
Ginger reportedly has anti-viral properties.
milestogo
(16,829 posts)mahina
(17,649 posts)Recursion
(56,582 posts)a la izquierda
(11,791 posts)I had a panic attack from my dreams one night.
Laura PourMeADrink
(42,770 posts)defacto7
(13,485 posts)MontanaMama
(23,313 posts)But Ill become one if thats what it takes. Bottoms up!
mahina
(17,649 posts)If I recall correctly, diarrhea, headaches, blurred vision, nausea, and really grumpy mood.
But breathing!
Response to intrepidity (Original post)
uponit7771 This message was self-deleted by its author.
uponit7771
(90,335 posts)jmowreader
(50,557 posts)Quinine has side effects and we dont have much malaria here, so they put in just enough quinine to flavor the drink.
And dont get the idea that you can make up for it by drinking more tonic water...youd be into Water Intoxication territory (which can be fatal) before you drank enough tonic water to do anything for your malaria or coronavirus.
On the other hand, itd have to work as well as anything Trump might suggest.
Native
(5,942 posts)in it because it's so old it's not patentable. Surprised?