University of Minnesota ivermectin trial nearing completion

[iemanja]

University of Minnesota researchers expect to finish enrollment this week in the nation's first clinical trial of ivermectin to treat COVID-19, meaning that the study's highly anticipated results are a few weeks away.

The COVID-OUT study is reviewing combinations of three common drugs, including the antidepressant fluvoxamine and the diabetes treatment metformin, but gained attention for its inclusion of the controversial ivermectin. . . .

"The aim of the study is to see if these medications make you feel better sooner and prevent hospitalization," said Dr. Rajesh Prabhu, an Essentia infectious disease specialist.

Bramante is not allowed to see the patient data from the U study until after enrollment is finished, but said it is a positive sign that a data safety monitoring board has allowed it to continue. That means the drugs aren't causing harm — which was expected because they are already used commonly for other purposes — but also there is no proof yet they absolutely work or don't work against COVID-19.

"The fact that is hasn't been stopped early is a good sign," Bramante said. "We might not ultimately have a statistically significant result or we might. We will know very soon."

https://www.startribune.com/university-of-minnesota-ivermectin-trial-nearing-completion/600139471/

[maxsolomon]

1. I have an Ivermectin prescription.

under the brand name Soolantra. it's topical. keeps my skin from reacting to little Demodex mites.

it has its uses, but it is not an antiviral.

[iemanja]

2. It will be interesting to see what the results of this study are

[abqtommy]

3. I hope they'e double-blinding these studies to guard against false results due to

The Placebo Effect, y'know, where something appears to work just because people want it
to. And no, I don't just expect everyone who does studies to do it right.

[iemanja]

4. Of course

The U of M is one of the country's leading medical research institutions. They receive hundreds of millions in federal grants. They know how to do a proper study.

[HUAJIAO]

6. THANK YOU.

[blogslug]

5. sigh

I guess the point of this study is to create hard data about the (in)effectiveness of the drug for Covid. I'm just sad. Even if the data shows it has no benefit, the lunatics/grifters will just say the study is bogus.

[HUAJIAO]

7. And if the study shows it DOES have a benefit......?

[Nevilledog]

8. Apologize to all the people dead of Covid who treated themselves with Ivermectin

[iemanja]

13. the premise or research question isn't that it cures COVID

but whether it and the other two drugs delay hospitalization.

[Nevilledog]

16. People TAKING Ivermectin think it keeps them from catching it....

And then when they catch it they think it'll keep them from dying.

[iemanja]

18. Well obviously

They are full of it.

[blogslug]

9. I'm all for treatments that work

If that happens then, good. People should still get vaccinated and boosted. And until the world gets control of this plague, they should social-distance and mask up too.

[HUAJIAO]

21. I agree with you....

[maxsolomon]

11. then, basically, the gubmint's entire Covid response is invalidated.

hope you're not rooting for that outcome.

[HUAJIAO]

22. I'm rooting for whatever saves people from horrendous symptoms and death.

[Marcuse]

10. Any beneficial effect on COVID will be huge news.

[bucolic_frolic]

12. Hope the researchers are prepared to be called Frauds /nt

[iemanja]

15. because you don't like the fact that they dared

to research the question? So much for caring about science. UMN researchers are most certainly not frauds, but you seem furious that they have even investigated whether ivermectin and two other drugs delay symptoms and hospitalization.

[bucolic_frolic]

17. NO, because that's what MAGA will call them when they say ivermectin failed.

[HUAJIAO]

23. What if they discover that it DOES work to reduce symptoms and save people from death?

[Scrivener7]

14. There actually has been one good ivermectin study that I read. Double blind, randomized etc.

It showed that there was no statistical difference between ivermectin and placebo EXCEPT that of those in the study who ended up hospitalized, those taking ivermectin were sick enough to be hospitalized a few days sooner.

[Disaffected]

19. Ivermectin showed early promise

with in vitro ("test tube" ) experiments in which Corona antiviral effectiveness was apparently observed (conducted at an Australian university IIRC). Trouble is, the concentrations of Ivermectin necessary for effective antiviral activity are far higher than could be tolerated by the body (one reason being that it tends to accumulate in and cause damage to the liver or kidneys rather than the lung tissue that Corona attacks).

One reason for these U or M trials may be to simply again demonstrate that Ivermectin is not useful for this application - sort of like the Laetrile trials that were conducted years ago to officially dissuade folks from taking the stuff in lieu of conventional cancer treatment (which was unfortunately quite common at the time at quack "cancer clinics" ).

Ivermectin - the new Laetrile...

[lame54]

20. This study is redundant...

Seeing as the anti-vaxxers are all doing their own research