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slipslidingaway

(21,210 posts)
Sat Sep 10, 2016, 01:17 AM Sep 2016

There’s new hope for blood cancers, and it comes from umbilical cords

https://www.washingtonpost.com/national/health-science/theres-new-hope-for-blood-cancers-and-it-comes-from-umbilical-cords/2016/09/02/04620816-2d89-11e6-9b37-42985f6a265c_story.html

"Jessie Quinn of Sacramento was 36 years old when loss of appetite, weight loss, some eye issues and finally pelvic pain sent her to the emergency room in 2010. Tests quickly revealed she had acute myeloid leukemia — a type of blood cancer that progresses quickly — and doctors told her that chemotherapy would probably not be enough; she would need a bone-marrow transplant.

Quinn, who has a science background, knew that finding a donor would be difficult. In college, she had donated to a bone-marrow registry after learning that people like her, with a mixed racial heritage, have a much harder time than others finding a match.

In fact, when she and her doctors scoured the registry for a match for her, only one name came up: her own.

“I didn’t know whether to laugh or cry,” Quinn said.

While searching unsuccessfully for a match for five months, Quinn underwent four cycles of chemotherapy to keep the leukemia at bay. What eventually saved her, though, was an experimental transplant using stem cells from the blood of a baby’s umbilical cord, an approach that can be used without perfectly matching blood types...."


This month is blood cancer awareness month and they are hoping to raise 300K, this is just a drop in the bucket compared to what is spent on wars or elections, if you can please help, thank you!


Leukemia and lymphoma society
http://www.lls.org/






6 replies = new reply since forum marked as read
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There’s new hope for blood cancers, and it comes from umbilical cords (Original Post) slipslidingaway Sep 2016 OP
Not a scientist, but I have have believed for a number of years that umbilical cords No Vested Interest Sep 2016 #1
I did not realize that the Hutch was doing trials to expand cord transplants ... slipslidingaway Sep 2016 #2
There are amazing cells sharp_stick Sep 2016 #3
The science behind this amazing .... slipslidingaway Sep 2016 #5
kinda cant believe this isnt used more. mopinko Sep 2016 #4
Well transplanting one's immune system is not for the faint of heart ... slipslidingaway Sep 2016 #6

No Vested Interest

(5,166 posts)
1. Not a scientist, but I have have believed for a number of years that umbilical cords
Sat Sep 10, 2016, 02:09 AM
Sep 2016

are great resources for study and healing that have been largely ignored for many years.

With the majority of umbilical cords disposed of following birth, opportunities have been lost that could have solved research problems, at a time (early 2000's- Bush administration) when public policy made it near impossible to utilize stem cells from pre-term births or abortions.

slipslidingaway

(21,210 posts)
2. I did not realize that the Hutch was doing trials to expand cord transplants ...
Sat Sep 10, 2016, 02:54 AM
Sep 2016

and very happy to hear of their success for those who do not find a match and as we all become 'more blended' the hopes of finding a perfect match becomes more challenging. One person we became familiar with in 2010 finally found a match on a Asian registry, unfortunately he is now looking at a second transplant and the original donor is not available.

Since my husband's first transplant in 2010 and subsequent second transplant on 12/31/14 after relapse they have come such a long way! Cord plus haplos, as a bridge, have become somewhat commonplace in recent years, but that is more complicated when you add another immune system to the mix. If one can expand a singular (cord) donor for transplant and possibly have additional cells to use in case of relapse, DLI (donor lymphocyte infusion) that would be fantastic! We lived with a couple of people in 2015 at Hope Lodge in NYC that had a combo, haplo plus one cord and haplo plus two cords, both are doing well. In one instance the dominant cord took over, in the other the haplo took over.

Yes we need to pay attention to science and fight those who block the advancement of giving life another chance.

We're getting there, day by day

sharp_stick

(14,400 posts)
3. There are amazing cells
Sat Sep 10, 2016, 08:47 AM
Sep 2016

in cord blood. When I was doing my undergrad research project I had to hang around the maternity ward and collect cord blood samples from willing mom's and dad's.

The white blood cells especially are so different from those in even a few days old baby.

slipslidingaway

(21,210 posts)
5. The science behind this amazing ....
Wed Sep 14, 2016, 02:56 AM
Sep 2016

you can transplant 2 or 3 cord cells into someone and the dominant cells will win, combine that with a haplo transplant, well it is to much for my mind to handle!

I guess your statement about the 'newly born' cells takes on a whole a whole new meaning, they are fresh, not willing to do combat, but yet the stronger cells live on and the weak cells die off.

It is amazing, thanks for being part of science to help us live longer!

mopinko

(70,103 posts)
4. kinda cant believe this isnt used more.
Sat Sep 10, 2016, 11:14 AM
Sep 2016

it was becoming a thing when my kids were born, over 20 years ago. considering the bottlenecks around embryos...

better late than never, tho.

slipslidingaway

(21,210 posts)
6. Well transplanting one's immune system is not for the faint of heart ...
Wed Sep 14, 2016, 03:17 AM
Sep 2016

having watched my husband's immune system being killed off four times and hoping the disease is killed off and that the new cells take off is a little stressful!

But I do say there is an unexplored area that will be filled in the future, that being said billed costs last year were 850K, out of pocket about 10% plus premiums and does not touch travel and lost wages. No wonder people that have HC insurance in the US are filing for bankruptcy at alarming rates, we have been dodging the bullet for 6 six plus years thanks in large part to family in the UK who have an 'inferior' HC system.

We need to wake up in the US, nothing is perfect in the UK or Canada, but this is not so great either?





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