HomeLatest ThreadsGreatest ThreadsForums & GroupsMy SubscriptionsMy Posts
DU Home » Latest Threads » Forums & Groups » Main » Latest Breaking News (Forum) » FDA approves much-debated...

Mon Jun 7, 2021, 03:45 PM

FDA approves much-debated Alzheimer's drug panned by experts

Source: AP

By MATTHEW PERRONE

WASHINGTON (AP) ó Government health officials on Monday approved the first new drug for Alzheimerís disease in nearly 20 years, disregarding warnings from independent advisers that the much-debated treatment hasnít been shown to help slow the brain-destroying disease.

The Food and Drug Administration said it granted approval to the drug from Biogen based on results that seemed ďreasonably likelyĒ to benefit Alzheimerís patients.

Itís the only drug that U.S. regulators have said can likely treat the underlying disease, rather than manage symptoms like anxiety and insomnia.

The decision, which could impact millions of older Americans and their families, is certain to spark disagreements among physicians, medical researchers and patient groups. It also has far-reaching implications for the standards used to evaluate experimental therapies, including those that show only incremental benefits.



This image provided by Biogen on Monday, June 7, 2021 shows a vial and packaging for the drug Aduhelm. On Monday, June 7, 2021, the Food and Drug Administration approved Aduhelm, the first new medication for Alzheimerís disease in nearly 20 years, disregarding warnings from independent advisers that the much-debated treatment hasnít been shown to help slow the brain-destroying disease. (Biogen via AP)


Read more: https://apnews.com/article/science-government-and-politics-business-health-2147d824af9cfde629041d83d9ca7a8d

10 replies, 1572 views

Reply to this thread

Back to top Alert abuse

Always highlight: 10 newest replies | Replies posted after I mark a forum
Replies to this discussion thread

Response to Omaha Steve (Original post)

Mon Jun 7, 2021, 04:30 PM

1. Just watched a financial analyst explain that it doesn't matter if it works or not, profit-wise.

There are no other treatments, and people are desperate.

She said doctors will prescribe this even if they don't believe it will work, because they don't want to look patients and family members in the eye and dash their hopes.

Biogen up about 40% on the day.

Reply to this post

Back to top Alert abuse Link here Permalink


Response to Midnight Writer (Reply #1)

Mon Jun 7, 2021, 05:50 PM

2. There really aren't any treatments for other kinds of dementia, either.

Families are desperate, I agree. Watching a loved one devolve into a child, and sometimes an intransigent, belligerent child is so hard on everyone... including the patient. We've had mom on aricept for years to no avail. But you hate to give up the only treatment, even if it's not showing any improvement. Mom doesn't have Alzheimer's. She has "normal" age-related dementia, but she can get downright mean and abusive at times. Not to mention she's four times my size. I'd hoped with the right medicine I'd be able to keep her here with us in an environment that was familiar and with family who love her. The hardest thing I ever had to do was to admit the medicine wasn't helping, and neither could I. The best thing I could do was to hunt for a memory care home where there were people trained in this phase of life. But gods, even still I can beat myself up for it; wondering if there was more I could have done.

The group that comes up with a drug or treatment regimen that actually works to slow dementia will make a mint. I don't care. This disease is just too heart wrenching.

Reply to this post

Back to top Alert abuse Link here Permalink


Response to slightlv (Reply #2)

Mon Jun 7, 2021, 07:24 PM

3. Try medical cannabis chocolates or other chewables. It helped my Mom be less belligerent and happier

and also helped with pain and sleeping somewhat.

It's safer than the other drugs the doctors load patients up on. Mom did great on this until she had a fall and fractured her back; now she's in care facility and doctors won't allow the cannabis so they've tried various other drugs that don't really work but have side effects such as making her groggy.

Reply to this post

Back to top Alert abuse Link here Permalink


Response to Liberty Belle (Reply #3)

Mon Jun 7, 2021, 11:08 PM

7. There's research that suggests cannabis does more for dementia than just help with behavior.

There havenít been enough rigorous controlled studies, of course, largely due to the schedule 1 mischaracterization in the US, and also to the politicization and lack of pharmaceutical co. support.

Reply to this post

Back to top Alert abuse Link here Permalink


Response to Liberty Belle (Reply #3)

Mon Jun 7, 2021, 11:08 PM

8. There's research that suggests cannabis does more for dementia than just help with behavior.

There havenít been enough rigorous controlled studies, of course, largely due to the schedule 1 mischaracterization in the US, and also to the politicization and lack of pharmaceutical co. support.

Reply to this post

Back to top Alert abuse Link here Permalink


Response to slightlv (Reply #2)

Mon Jun 7, 2021, 08:26 PM

5. I have FTD


Trazodone has shown good results in trials. I'm on it. A safe drug that has been around a long time.

https://www.researchgate.net/publication/8527842_Frontotemporal_Dementia_A_Randomised_Controlled_Trial_with_Trazodone

Results of this first placebo-controlled trial suggest that trazodone is an effective treatment for the behavioural symptoms of FTD.

Back to my ball game, NU vs Arkansas.

Reply to this post

Back to top Alert abuse Link here Permalink


Response to Omaha Steve (Reply #5)

Mon Jun 7, 2021, 10:04 PM

6. I've been taking trazodone for 20+ years for sleep...

... That's very interesting... Thank you Omaha Steve!

It's super helpful for sleep, and I have lovely dreams.... And wake up in a good mood everyday.

Reply to this post

Back to top Alert abuse Link here Permalink


Response to Omaha Steve (Reply #5)

Tue Jun 8, 2021, 06:32 AM

10. Good luck with that Omaha.


Lost a parent to dementia. Fortunately she had really great care

at a local retirement home. A big salute to the aids at these

homes for retirement. ..

Reply to this post

Back to top Alert abuse Link here Permalink


Response to slightlv (Reply #2)

Mon Jun 7, 2021, 11:28 PM

9. How can you tell the difference between age-related

memory loss and Alzheimerís?

Reply to this post

Back to top Alert abuse Link here Permalink


Response to Omaha Steve (Original post)

Mon Jun 7, 2021, 08:06 PM

4. What's going on in a fatty brain

originates in the quantity and type of fats in the liver, in my opinion. My personal plan is high quality oils - fish, EV olive oil, lecithin as an emulsifier - but decades in advance and in small to moderate amounts.

Reply to this post

Back to top Alert abuse Link here Permalink

Reply to this thread