Ketamine cousin rapidly lifts depression without side effects
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Source: Medical Xpress
GLYX-13, a molecular cousin to ketamine, induces similar antidepressant results without the street drug side effects, reported a study funded by the National Institute of Mental Health (NIMH) that was published last month in Neuropsychopharmacology.
Major depression affects about 10 percent of the adult population and is the second leading cause of disability in U.S. adults, according to the World Health Organization. Despite the availability of several different classes of antidepressant drugs such as selective serotonin reuptake inhibitors (SSRIs), 30 to 40 percent of adults are unresponsive to these medications. Moreover, SSRIs typically take weeks to work, which increases the risk for suicide.
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GLYX-13 and ketamine produced rapid acting (1 hour) and long-lasting (24 hour) antidepressant-like effects in the rats. Fluoxetine, an SSRI that typically takes from 2-4 weeks to show efficacy in humans, did not produce a rapid antidepressant effect in this study. As expected, the scrambled GLYX-13 showed any antidepressant-like effects. The researchers observed none of the aforementioned side effects of ketamine in the GLYX-13-treated rats.
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The results are consistent with data from a recent Phase 2 clinical trial, in which a single administration of GLYX-13 produced statistically significant reductions in depression scores in patients who had failed treatment with current antidepressants. The reductions were evident within 24 hours and persisted for an average of 7 days. After a single dose of GLYX-13, the drug's antidepressant efficacy nearly doubled that seen with most conventional antidepressants after 4-6 weeks of dosing. GLYX-13 was well tolerated and it did not produce any of the schizophrenia-like effects associated with other NMDA receptor modulating agents.
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Read more: http://medicalxpress.com/news/2013-05-ketamine-cousin-rapidly-depression-side.html
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. . . occurs in the book, Party Monster, by James St. James, about the murder of a young, gay Latino drug dealer by club kid extraordinaire Michael Alig, who was a club fixture here in New York back in the days when Peter Gatien reigned supreme as New York's nightlife impresario. St. James describes a k-hole in his author's foreword, in what is surely one of the funniest, brilliant and absolutely spot-on descriptions of a k-hole that ever has or ever will be written (not, of course, that I would know anything about such things 
). You can read it in the online preview at Amazon. Click on the link below, then scroll about five or six pages in and begin reading. It is truly a read you won't regret!
Here's the link: http://www.amazon.com/Party-Monster-Fabulous-Murder-Clubland/dp/B001KBZ6G6/ref=sr_1_1?s=books&ie=UTF8&qid=1369968178&sr=1-1&keywords=Party+Monster#reader_B001KBZ6G6
used to kill my alcoholism. I remember as a youth, taking one dose and any desire for a drink vanished completely. Only years after of depression did the desire to drink re-emerge.
Of course that's against the law now. Apparently a complete stranger know what ails me better than I and it's gonna cost. Where does it say in the fine print there is a fix guarantee, no where? Oh.....
-p
Response to Phlem (Reply #6)
Response to Phlem (Reply #12)
