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(15,265 posts)
Fri Jul 31, 2020, 12:15 AM Jul 2020

World-first gene therapy reverses Alzheimer's memory loss in mice


"Scientists in Australia have made an exciting breakthrough in Alzheimer’s research, demonstrating what they describe as the first gene-therapy-based approach for treating advanced forms of the disease. Through experiments in mice, the team was able to show how activating a key enzyme in the brain can prevent the kind of memory loss associated with advanced forms of Alzheimer's, and even reverse it.
The research was carried out at Macquarie University, where dementia researchers and brothers Lars and Arne Ittner were investigating the role of a key enzyme in the brain called p38gamma. Through previous research, the brothers had shown that by activating this enzyme in mice with advanced dementia, they could modify a protein that prevents the development of Alzheimer’s symptoms."
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World-first gene therapy reverses Alzheimer's memory loss in mice (Original Post) CentralMass Jul 2020 OP
Sounds promising.  ( n/t ) Make7 Jul 2020 #1
K/R appalachiablue Jul 2020 #2
(Shades of Flowers for Algernon.) Hope it progresses! Guilded Lilly Jul 2020 #3
That would be GREAT NEWS! But I have to ask, how do they tell if a mouse has dementia? nt napi21 Jul 2020 #4
My exact thought. demosincebirth Jul 2020 #5
There are memory tests intrepidity Jul 2020 #6


(7,180 posts)
6. There are memory tests
Fri Jul 31, 2020, 01:46 AM
Jul 2020

Like, reciting 5 words, person, woman, man...

No, but there are memory tests, like seeing if they can remember where a platform in a swimming pool is, to get out of the water (Morris Water Maze test). Things like that.

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