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Celebration

(15,812 posts)
Sat Jan 7, 2012, 03:44 PM Jan 2012

First biological proof for acupuncture?

http://scienceblog.com/51134/acupuncture-found-to-lower-stress-protein/

Acupuncture significantly reduces levels of a protein in rats linked to chronic stress, researchers at Georgetown University Medical Center (GUMC) have found. They say their animal study may help explain the sense of well-being that many people receive from this ancient Chinese therapy.

Published online in December in Experimental Biology and Medicine, the researchers say that if their findings are replicated in human studies, acupuncture would offer a proven therapy for stress, which is often difficult to treat.

“It has long been thought that acupuncture can reduce stress, but this is the first study to show molecular proof of this benefit,” says the study’s lead author, Ladan Eshkevari, Ph.D., an assistant professor at Georgetown’s School of Nursing & Health Studies, a part of GUMC.

.....................................................................

She found NPY levels in the experimental group came down almost to the level of the control group, while the rats that were stressed and not treated with Zuslanli acupuncture had high levels of the protein.

In a second experiment, Eshkevari stopped acupuncture in the experimental group but continued to stress the rats for an additional four days, and found NPY levels remained low. “We were surprised to find what looks to be a protective effect against stress,” she says.


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laconicsax

(14,860 posts)
1. I find it interesting that this piece doesn't give the results of the sham group.
Sat Jan 7, 2012, 05:58 PM
Jan 2012

There were three groups: control, "sham" acupuncture, and "real" acupuncture. The article only gives the results for the first and third groups.

I wonder why...

Celebration

(15,812 posts)
4. well the abstract does, and the sham group didn't work
Sat Jan 7, 2012, 06:22 PM
Jan 2012
http://www.ncbi.nlm.nih.gov/pubmed/22156045

"The effect was specific, as NPY in Sham-EA rats was not different than observed in stress-only rats."

mzteris

(16,232 posts)
7. not sure what you mean by "didn't work"
Sat Jan 7, 2012, 06:34 PM
Jan 2012
http://www.healthcmi.com/index.php/acupuncturist-news-online/473-acupuncturestressgeorgetownstudy

Electro-acupuncture was applied to acupuncture point St36 in laboratory rats exposed to stressful cold. The control group and the sham acupuncture group showed no change in NPY. However, the group receiving acupuncture showed a significant and long-term decrease in NPY production.


Sounds like it "worked" to me. . . the "sham" didn't work is that what you're saying?

Celebration

(15,812 posts)
8. the sham group had no changes, while the experimental group did
Sat Jan 7, 2012, 06:43 PM
Jan 2012

What I find most interesting is that the effect in the experimental group was actually protective for future stress.

mzteris

(16,232 posts)
6. different link:
Sat Jan 7, 2012, 06:29 PM
Jan 2012
http://www.healthcmi.com/index.php/acupuncturist-news-online/473-acupuncturestressgeorgetownstudy

Electro-acupuncture was applied to acupuncture point St36 in laboratory rats exposed to stressful cold. The control group and the sham acupuncture group showed no change in NPY. However, the group receiving acupuncture showed a significant and long-term decrease in NPY production.

Acupuncture at ST36 prevents chronic stress-induced increases in neuropeptide Y in rat. Ladan Eshkevari1, Rupert Egan2, Dylan Phillips3, Jason Tilan1, Elissa Carney2, Nabil Azzam4, Hakima Amri5 and Susan E Mulroney2. Exp Biol Med
7 December 2011 EBM.2011.011224 .


****

http://www.news-medical.net/news/20111220/Acupuncture-can-reduce-protein-associated-with-chronic-stress.aspx

It has long been thought that acupuncture can reduce stress, but this is the first study to show molecular proof of this benefit," says the study's lead author, Ladan Eshevari, Ph.D., an assistant professor at Georgetown's School of Nursing & Health Studies, a part of GUMC.
Eshkevari, who is also a nurse anesthetist as well as a certified acupuncturist . . .While traditional Chinese acupuncture has been thought to relieve stress -in fact, the World Health Organization states that acupuncture is useful as adjunct therapy in more than 50 disorders, including chronic stress - Eshevari says that no one has biological proof that it does so.

So she designed a study to test the effect of acupuncture on blood levels of neuropeptide Y (NPY), a peptide that is secreted by the sympathetic nervous system in humans. This system is involved in the "flight or fight" response to acute stress, resulting in constriction of blood flow to all parts of the body except to the heart, lungs, and brain (the organs most needed to react to danger)."

. . . The study utilized four groups of rats for a 14-day experiment: a control group that was not stressed and received no acupuncture; a group that was stressed for an hour a day and did not receive acupuncture; a group that was stressed and received "sham" acupuncture near the tail; and the experimental group that were stressed and received acupuncture to the Zuslanli spot on the leg.
She found NPY levels in the experimental group came down almost to the level of the control group, while the rats that were stressed and not treated with Zuslanli acupuncture had high levels of the protein. . . "
 

laconicsax

(14,860 posts)
2. And because it's a different issue...
Sat Jan 7, 2012, 06:03 PM
Jan 2012

There's been "biological" "proof" that sticking needles in the skin has concrete effects for a while.

What's never come even close to being proven is that it makes any difference where the needles go--meridians are unscientific bullshit.

HuckleB

(35,773 posts)
3. Indeed.
Sat Jan 7, 2012, 06:15 PM
Jan 2012

But, of course, there is "biological" proof that touching the skin has concrete effects. The body reacts to touch, so it's certainly going to react to a needle prick.

HuckleB

(35,773 posts)
10. In other studies, the sham group responded while the acupuncture did not.
Sat Jan 7, 2012, 07:10 PM
Jan 2012

These are small studies, and they're results are only worthy in terms of moving study forward. They are almost meaningless. That was noted in the OP I offered earlier today.

This explains this at length:

Are Most Medical Studies Wrong?
http://theness.com/neurologicablog/index.php/are-most-medical-studies-wrong/

More studies on this matter... just as examples of the contradicting small studies that make this whole discussion nearly pointless:

Sham acupuncture is better than "true" acupuncture
http://scienceblogs.com/insolence/2008/04/sham_acupuncture_is_better_than_true_acu.php

Acupuncture for Pain No Better Than Placebo -- And Not Without Harm, Study Finds
http://www.sciencedaily.com/releases/2011/03/110324104147.htm

mzteris

(16,232 posts)
11. I'm surue we could all go pick and choose "studies"
Sat Jan 7, 2012, 07:35 PM
Jan 2012

to support our positions...

leave it go, Huck. We'll never agree on this one. My experience beats your opinion. In my opinion, of course.

HuckleB

(35,773 posts)
12. Again, it does not appear that you are responding to the content of my posts.
Sat Jan 7, 2012, 08:21 PM
Jan 2012

Thus, there doesn't seem to be anything to agree upon or disagree upon.

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