Science
Related: About this forumThe Bright Side of Prions
By Randal Halfmann
In Kurt Vonneguts Cats Cradle, scientists create a highly stable form of crystalline water called ice-nine that stays frozen even at high temperatures. Ice-nine instantly freezes any liquid water it touches. Its accidental release into nature solidifies the oceans and all contiguous bodies of water, and global catastrophe threatens our existence. Luckily for us, ice-nine is fictitious. But its biological counterpart, unfortunately, is not. The misfolded proteins known as prions are very real.
Prions are proteinaceous infectious particles, formed when normal proteins misfold and clump together. Biochemists Byron Caughey of the National Institute of Allergy and Infectious Diseases and Peter Lansbury of Brigham and Womens Hospital were among the first to explore the analogy between Vonneguts ice-nine and prions in their 1995 review of scrapie, an infectious and deadly neurological disease of sheep.1 Like ice-nine, the particles that spread scrapie consist of highly stable crystals of a normally innocuous material found in the brains of sheep. Crystalline clumps of a misfolded version of this protein coax other molecules of the same protein to fold into the aberrant conformation. The process continues until virtually all of that protein in a cell or tissue has been converted to prions. In the case of scrapie and other mammalian prion diseases, the consequence of this self-amplifying cycle is an accumulation of toxic clumps of proteins that destroys neurons and invariably kills the organism.
The chilling similarity between the modus operandi of ice-nine and prions is an apt illustration of the long-standing and well-deserved reputation of prions as catastrophic agents. Researchers are identifying more and more cases of prion-like protein misfolding that cause neurodegenerative diseases.
But a different side of prions is also coming to light. Many newly discovered prions and prion-like proteins do not appear to cause disease at all. On the contrary, some even protect against it. Still other prions are turning out to be key players in basic biological processes. (See illustration.) These discoveries are driving a new appreciation for prions as versatile components in the machinery of life, a paradigm that has fostered conceptual advances in fields as diverse as signal transduction, memory formation, and evolution.
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http://www.the-scientist.com/?articles.view/articleNo/38721/title/The-Bright-Side-of-Prions/
The Wielding Truth
(11,415 posts)siligut
(12,272 posts)http://www.ncbi.nlm.nih.gov/pubmed/12756137
In Alzheimer's a complex of structures/functions go awry, but tau protein and beta amyloid plaque formation appear to be the initiating factors. I wonder too is it possible that it is prions that cause the tau protein to undergo phosphorylation? So then is it possible to create a vaccine against those prions?
Gothmog
(145,176 posts)I have reading up on this disease and this article is interesting.