Leading COVID-19 vaccine candidates rely on new technologies that have fast-tracked development and testing. Vaccines from Pfizer and Moderna have completed early phase 3 clinical trials and are reportedly under review at the US FDA for emergency use authorization (EUA) although safety surveillance continues. This video explains the principles underlying the leading DNA, messenger RNA (mRNA), and viral vector vaccine candidates, and how they might induce immunity to SARS-CoV-2 infection.

With the Pfizer and Moderna coronavirus vaccines reportedly under review at the US FDA for emergency use authorization (EUA), Paul A. Offit, MD of the Children's Hospital of Philadelphia, returns to JAMA's Q&A series to provide an update on what to expect, prospects for vaccine rollout and distribution in the coming months, and ongoing safety surveillance. Recorded December 2, 2020.

Fall 2020 is seeing continued global spread of COVID-19 with uncertainties about the effects of school reopenings on transmission and the prospects for dual COVID-19 and influenza outbreaks heading into colder months. Vaccine trials are heading into phases 2 and 3, and the FDA’s earlier-year reliance on emergency use authorizations (EUAs) under perceived political pressures to deliver pandemic solutions is raising concerns about the integrity of approval processes for vaccines potentially offered to millions of otherwise healthy people.

Browse the JAMA Network COVID-19 collection below, including Q&A's with NIAID's Anthony Fauci, an interactive map of the outbreak courtesy of The Johns Hopkins Center for Systems Science and Engineering, and past publications on vaccine development, infection control, and public health preparedness.

So many weird perfume ads on TV at this time of year.

Featured twice on ABC's Good Morning America - song is "Christmas Can Can" by Straight No Chaser. This is my first year decorating and this is my first sequence ever. I built almost everything from scratch using wood and acrylic. I am a music/teacher director for a living (COVA Conservatory in Oakland and Centerville Presbyterian Church in Fremont), hence the massive instruments! The guitar is 17', the piano is 19' and the drums are standard. About 6,500 channels running around 70,000 lights. Come by and see it in person on the corner of Lafayette and Ruschin in Newark, California! Fair use for educational purposes. Merry Christmas everyone!

We can’t stop the Trumpistas from Trumping. We can’t stop the rest of them from pretending like they were never big Trump fans in the first place. But we can stop them running away from the facts or their record. We can remind them how they failed to stop Trump’s corruption and this murderous pandemic.

We can stop them skewing the political spectrum so far that the Biden team tacks to center ground that is already six steps to the right. We can hold the new White House to its promises at the same time as holding the old Republican party to what used to be its principles.

But this work comes at a price. Back in the late 19th century, the French writer Gustave Le Bon wrote that “the crowd” has never rewarded the truth.

“They turn aside from evidence that is not to their taste, preferring to deify error, if error seduce them,” he wrote. “Whoever can supply them with illusions is easily their master; whoever attempts to destroy their illusions is always their victim.”

You can reward the truth if you want to. It’s one of the best ways to demolish the legacy of the last four years.