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hlthe2b

(102,237 posts)
25. You should correct subject line to PREVENT. There ARE Veterinary Coronavirus vaccines
Sat May 16, 2020, 07:57 AM
May 2020

that are effective against Enteric Canine Coronavirus (CCoV) a common cause of diarrheal illness in young puppies, though they do not protect against the respiratory virus Respiratory Canine Coronavirus (CRCoV), The latter was discovered in dogs in England in 2003, usually causing mild respiratory disease,is genetically related to human cold coronaviruses (not COVID-19) and to the bovine coronavirus that causes both respiratory and enteric disease in cattle and other ruminants ((BCoVs), for which there is a vaccine to control the enteric effects, but not the respiratory variant. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094360/

Cats get a coronavirus that causes FIP (Feline Infectious Peritonitis), again NOT transmissible to other animals for which there is a vaccine that confers some protection in settings with wide spread, but is not considered adequate for use in lower risk settings.

There has long been a swine coronavirus vaccine (enteric) and those against the respiratory coronavirus (for which there are multiple coronavirus variants) in poultry as discussed below and here:
https://www.frontiersin.org/articles/10.3389/fvets.2019.00341/full

Abstract

Severe acute respiratory syndrome (SARS) emerged in China and spread globally as a human pandemic. It is caused by a new coronavirus (CoV) of suspect animal origin. The emergence of SARS stunned medical scientists, but veterinary virologists had previously recognized CoVs as causing fatal respiratory or enteric disease in animals with interspecies transmission and wildlife reservoirs. Because of its public health impact, major efforts are focused on development of SARS vaccines. Occurrence of CoV disease at mucosal surfaces necessitates the stimulation of local immunity, having an impact on the vaccine type, delivery and adjuvant needed to achieve mucosal immunity. Such immunity is often short-lived, requires frequent boosting and may not prevent re-infection, all factors complicating CoV vaccine design. SARS vaccine efforts should be enhanced by understanding the correlates of protection and reasons for the success or failure of animal CoV vaccines. This review will focus on studies of immunity and protection in swine to the enteric CoV, transmissible gastroenteritis (TGEV) versus the respiratory variant, porcine respiratory CoV (PRCV), comparing live, inactivated and subunit vaccines, various vaccine vectors, routes and adjuvants. In addition avian infectious bronchitis CoV (IBV) vaccines targeted for protection of the upper respiratory tract of chickens are discussed. Unfortunately, despite long-term efforts, effective vaccines to prevent enteric CoV infections remain elusive, and generally live, but not killed vaccines, have induced the most consistent protection against animal CoVs. Confirmation of the pathogenesis of SARS in humans or animals models that mimic SARS may further aid in vaccine design and evaluation.

https://www.ncbi.nlm.nih.gov/pubmed/15742624


Bottom line, there are LOTS of coronaviruses and SOME effective vaccines generally for those that cause more enteric illness. Not all coronaviruses cause potentially lethal illness in their hosts, but can serve as good models for vaccine development. But the challenge is signficant and far from a "sure thing." Not to mention that there is a significant risk for what we have seen in the disastrous attempts at a Dengue vaccine, for which there are four distinct serotypes and immunity from infection with one does not prevent later infection with another. That vaccine incorporated components of all four serotypes and induced what is known as antibody-dependent enhancement (ADE), in which the immune response to the first virus amplifies the effect of the second type in an overwhelming and potentially lethal manner.


That said, PLEASE correct your subject line. Vaccines are designed to PREVENT disease by inciting the body's immune system. They are not designed to be "TREATMENTS." This is a serious misunderstanding among the public made worse by Trummp's constant BS.
Even the annual flu vaccine isn't 100% effective. Throck May 2020 #1
I understand, I heard... FarPoint May 2020 #2
Ignore the man behind the curtain. Throck May 2020 #4
U.S. flu vaccine effectiveness by start year Celerity May 2020 #6
Yers...good information...but.... FarPoint May 2020 #10
I never implied they were the same, I just used the title in the article, but I did change it Celerity May 2020 #47
I realize that..good information... FarPoint May 2020 #50
hugz Celerity May 2020 #52
Celerity - it would be best if you change your title to say "U.S. Influenza Vaccine Effectiveness... erronis May 2020 #44
there is no coronavirus vaccine, and I just used the title in the article, but I will change it Celerity May 2020 #46
Thanks for the edit. I just saw the title on Wikipedia and understand what you meant. erronis May 2020 #56
I also assumed the URL was a dead giveaway (Influenza_vaccine#Effectiveness) Celerity May 2020 #59
Yeah, the early fall flu shots.. Maxheader May 2020 #7
Sorry Traildogbob May 2020 #29
Can't Find It Now, But... ProfessorGAC May 2020 #3
I think we as activist need to emphasize this concern... FarPoint May 2020 #5
The coronavirus mutates more slowly than the flu -- which means a vaccine will likely be effective Celerity May 2020 #9
Thanks! ProfessorGAC May 2020 #11
this following is a great article addressing the hysteria that was on here about mutations Celerity May 2020 #13
Good post. Thank you. N/t bluecollar2 May 2020 #19
yw Celerity May 2020 #21
I remember reading it, or something similar. tavernier May 2020 #30
Well...we have had corona viruses like the Acute Respiratory One since say 2000 FarPoint May 2020 #12
I thinks odds are pretty low for a vaccine any time soon, Trump, as usual is full of shit Celerity May 2020 #14
Exactly.... FarPoint May 2020 #16
The last 2 months before the election Biden is truly going to have to lay the hammer down Celerity May 2020 #18
I agree there... FarPoint May 2020 #20
assume he will lie about .. EVERYTHING, and in the worst possible way on the worst possible subjects Celerity May 2020 #23
I have seen Biden get furiously angry when his family is threatened, tavernier May 2020 #31
+100000 Celerity May 2020 #35
Some vaccines are simply deactivated virus. Aussie105 May 2020 #8
they are trying that type, and all other types as well Celerity May 2020 #15
FRONTLINE had very up-to-date info from scientists trying to develop a vaccine Hestia May 2020 #22
Ohhhh yes...I wanted to watch that... FarPoint May 2020 #24
This is what Trump does. Makes promises that has no science behind them. Baitball Blogger May 2020 #17
You should correct subject line to PREVENT. There ARE Veterinary Coronavirus vaccines hlthe2b May 2020 #25
Great information. Mike 03 May 2020 #42
THANK YOU. I was looking around for just this info -- I knew that vets had a few vaccines for Nay May 2020 #49
In his testimony, Dr. Bright confirmed there has never been a coronavirus vaccine. Native May 2020 #26
Excellent! FarPoint May 2020 #32
I have responded to you repeatedly. PLease correct your OP. Vaccines are NOT treatments. hlthe2b May 2020 #58
Never a HUMAN coronavirus vaccine. See my post upthread on veterinary vaccines for other coronavirus hlthe2b May 2020 #57
Putting Trump aside, if its not gonna happen why havent ANY doctors said so? oldsoftie May 2020 #27
Someone posted in this thread... FarPoint May 2020 #34
thank you oldsoftie May 2020 #55
Because ... never say never. Laelth May 2020 #36
Maybe it's time to investigate alternative treatments but that won't happen until big Pharma's in2herbs May 2020 #28
Too late. They Own Trump's Team. IMO it will have to be a group of Governors to push that forward. Ford_Prefect May 2020 #41
That's what I've been reading too Bettie May 2020 #33
No news about Remdesivir yet disndat May 2020 #45
The treatment aspect is where we should focus on something timely.. FarPoint May 2020 #51
Make no mistake about a promise from trump duforsure May 2020 #37
Why would there be? Warpy May 2020 #38
People keep saying "WHEN we get a vaccine..." but that should be: MrModerate May 2020 #39
I completely agree with that! FarPoint May 2020 #40
K & R Mrs. Overall May 2020 #43
The SARS vaccine never got past animal testing, it didn't work, then the money and virus went away Baclava May 2020 #48
Sars.. BGBD May 2020 #53
The fastest way to put this virus in check is monoclonal antibodies. roamer65 May 2020 #54
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