Major Pesticides Are More Toxic to Human Cells Than Their Declared Active Principles
Pesticides are used throughout the world as mixtures called formulations. They contain adjuvants, which are often kept confidential and are called inerts by the manufacturing companies, plus a declared active principle (AP), which is the only one tested in the longest toxicological regulatory tests performed on mammals. This allows the calculation of the acceptable daily intake (ADI)—the level of exposure that is claimed to be safe for humans over the long term—and justifies the presence of residues of these pesticides at “admissible” levels in the environment and organisms. Only the AP and one metabolite are used as markers, but this does not exclude the presence of adjuvants, which are cell penetrants. Our previous investigation showed unexpected APs for human cell toxicity in the adjuvants of glyphosate-based herbicides [1]. Ethoxylated adjuvants found in glyphosate-based herbicides were up to 10.000 times more toxic than the so-called active AP glyphosate [1] and are better candidates for secondary side effects. This may explain in vivo long-term toxicity from 0.1?ppb of the formulation and other toxicities that were not explained by a consideration of glyphosate alone [2–5]. These adjuvants also have serious consequences to the health of humans and rats in acute exposures [6, 7]. These findings prompted us to investigate the presence of similar toxic molecules in other classes of pesticides.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955666/
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